Development of vascular disease models to explore disease causation and pathomechanisms of rare vascular diseases

Abstract

As the field of medicine is striving forward heralded by a new era of next-generation sequencing (NGS) and integrated technologies such as bioprinting and biological material development, the utility of rare monogenetic vascular disease modeling in this landscape is starting to emerge. With their genetic simplicity and broader applicability, these patient-specific models are at the forefront of modern personalized medicine. As a collective, rare diseases are a significant burden on global healthcare systems, and rare vascular diseases make up a significant proportion of this. High costs are due to a lengthy diagnostic process, affecting all ages from infants to adults, as well as the severity and chronic nature of the disease. Their complex nature requires sophisticated disease models and integrated approaches involving multidisciplinary teams. Here, we review these emerging vascular disease models, how they contribute to our understanding of the pathomechanisms in rare vascular diseases and provide useful platforms for therapeutic discovery.

Overview of the Most Popular Currently Used Murine Models of Atherosclerosis

“…Secondly, there is a necessity to enhance and refine the models used for studying atherosclerosis and its various manifestations. It is imperative to employ rigorous approaches that promote swift progress in the field, enabling comprehensive exploration of hypothesis-generating aspects that arise from data-driven high-throughput research (Harper et al, 2022).…”

Diseases of blood vessels: Immune system involvement in vasculitis and vasculopathy

“…In this issue of Seminars in Immunopathology, the complexity of many forms of vascular diseases are detailed and discussed. Harper et al detail various methods to create patient-specific vascular disease models including use of primary cells derived from various patient biospecimens coupled with in vitro and in vivo vascular models and provide examples of successful approaches to study various rare vascular diseases [11]. Lee et al review the pathogenesis of a monogenic form of vasculitis discovered in 2014 known as deficiency of adenosine deaminase 2 (DADA2) [12].…”

PBAT/gelatin hybrid nanofibers based on post-double network bond processing as a promising vascular substitute

“…Vascular disease is a condition related to narrowing, blockage or trauma of blood vessels. [1][2][3] Despite the rapid development of vascular surgical skills and articial blood vessel replacement in recent years, there is still a problem of poor bioactivity and biocompatibility of articial blood vessel materials and imperious demands of stable articial blood vessels. [4][5][6] At present, the gold standard of vascular transplantation is still derived from autologous arteries or veins.…”