Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles

Contreras, Alejandra; Wiest, David L.

doi:10.1007/978-1-0716-2740-2_4

Cited by 3 publications

(8 citation statements)

References 111 publications

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“…S3). Taken together, these data suggest that the Vγ1Vδ6.3 TCR clonotypes that preferentially expand among NKγδT cells in Id3-deficient mice are also more capable of promoting NKγδT cell development in Id3-deficient progenitors in this acute assay, even when expressed beyond the fetal/perinatal window to which their development is normally restricted 27 .…”

Section: Resultsmentioning

confidence: 65%

“…The first such wave, peaks around embryonic day 14 (E14) and comprises Vγ3 + dendritic epidermal T cells (DETCs), which produce interferon-g (IFNγ) and home to the epidermis 25 . The next waves occur at E16 and E18 and comprise Vγ4 + and Vγ2 + subsets, respectively, which are associated with IL-17 production and residence in the lung, uterus, and lymphoid tissues 24,26,27 . The final wave begins during late fetal life and comprises Vγ1 + T lymphocytes, among which are the natural killer γδ T cell (NKγδT) subset [27][28][29][30] .…”

Section: Introductionmentioning

confidence: 99%

“…The next waves occur at E16 and E18 and comprise Vγ4 + and Vγ2 + subsets, respectively, which are associated with IL-17 production and residence in the lung, uterus, and lymphoid tissues 24,26,27 . The final wave begins during late fetal life and comprises Vγ1 + T lymphocytes, among which are the natural killer γδ T cell (NKγδT) subset [27][28][29][30] . NKgdT cells are characterized by a strereotypic Vγ1.1Vδ6.3 TCR, PLZF expression, and co-produciton of IL-4 and IFNγ without the need for prior activation 19,31,32 ; and their development is restricted to the late fetal/perinatal developmental window 19,31,32 .…”

Section: Introductionmentioning

confidence: 99%

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E protein control of NKγδT cell development through both generation and function of the stereotypic Vγ1Vδ6.3 TCR

Mihai,

Lee,

Shinton

et al. 2024

Preprint

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T cell receptor (TCR) signals regulate important developmental transitions through induction of the E protein antagonist, Id3; however, Id3-deficiency produces paradoxical effects on γδ T cell subsets. Here, we show here that Id3-deficiency attenuates the development of Vγ3-expressing γδ T cells, while markedly enhancing the development of Vγ1Vδ6.3-expressing NKγδT cells. Id3-deficiency does so by regulating both the generation of the stereotypic Vγ1Vδ6.3 TCR expressed by NKγδT cells and its capacity to support development. Indeed, we determined that theTrav15segment, which encodes the Vδ6.3 TCR subunit, is directly bound by E proteins that control its expression. Moreover, once expressed, the resulting Vγ1Vδ6.3 TCR in capable of specifying the innate-like NKγδT cell fate in a cell-autonomous and developmentally-unrestricted manner that is restrained by the Id3/E axis. Together, these data indicate that the paradoxical behavior of NKγδT cells in the Id3-deficient setting is entirely determined by its stereotypic Vγ1Vδ6.3 TCR complex.

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Section: Resultsmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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E protein control of NKγδT cell development through both generation and function of the stereotypic Vγ1Vδ6.3 TCR

Mihai,

Lee,

Shinton

et al. 2024

Preprint

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mentioning

confidence: 99%

“…Cooking fatigue and interest in finding new and healthy recipes have been commonly cited by consumers cooking at home during the COVID-19 era 1,2 . Consumers have also indicated that they anticipate cooking more at home even after the pandemic ends, 1 suggesting that healthy habits and strategies for healthy family meals learned during the pandemic have the potential to persist in the future. In response to these trends, multiple health organizations issued recommendations for eating at home, 3,4 emphasizing consumption of fruits, vegetables, whole grains, and vitamin- and mineral-rich foods.…”

mentioning

confidence: 99%

Food Blogs to Family Meals

Spaccarotella¹,

Gido²

2022

CIN: Computers, Informatics, Nursing

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This study examined the quality and healthfulness of articles and recipes on food blogs to inform nurses, other health professionals, and patients using these as resources. Recipes from 50 blogs on Feedspot.com were analyzed for nutrient content and congruency of nutrition information. Of the 178 recipes, 5.6% were low calorie, 7.3% were low in total fat, 15.2% were low sodium, and 89.3% had ≤100 kcal of total sugar. Snack recipes contained significantly less mean sodium (P = .001), and 21% of blogs provided nutrition tips with incongruent or mixed congruency recommendations. Nurses, other health professionals, and consumers should evaluate cooking blogs carefully when using them for nutrition and recipe advice.

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E proteins control the development of NKγδT cells through their invariant T cell receptor

Mihai,

Lee,

Shinton

et al. 2024

Nat Commun

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T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces different phenotypes in distinct γδ T cell subsets. Here, we show that Id3 deficiency impairs development of the Vγ3+ subset, while markedly enhancing development of NKγδT cells expressing the invariant Vγ1Vδ6.3 TCR. These effects result from Id3 regulating both the generation of the Vγ1Vδ6.3 TCR and its capacity to support development. Indeed, the Trav15 segment, which encodes the Vδ6.3 TCR subunit, is directly bound by E proteins that control its expression. Once expressed, the Vγ1Vδ6.3 TCR specifies the innate-like NKγδT cell fate, even in progenitors beyond the normally permissive perinatal window, and this is enhanced by Id3-deficiency. These data indicate that the paradoxical behavior of NKγδT cells in Id3-deficient mice is determined by its stereotypic Vγ1Vδ6.3 TCR complex.

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Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles

Cited by 3 publications

References 111 publications

E protein control of NKγδT cell development through both generation and function of the stereotypic Vγ1Vδ6.3 TCR

E protein control of NKγδT cell development through both generation and function of the stereotypic Vγ1Vδ6.3 TCR

Food Blogs to Family Meals

E proteins control the development of NKγδT cells through their invariant T cell receptor

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