Developmental alterations in offspring of female rats orally intoxicated by aluminum lactate at different gestation periods

Abstract

Pregnant rats were treated orally with aluminum lactate (400 mg Al/kg/day) during three periods of gestation to determine the treatment's influence on mortality, weight gain, neuromotor maturation, and learning abilities of their pups. No effect of treatment on litter size, mortality rate, and weight gain of pups was detected. In the negative geotaxis test, the scores of pups from females treated during the second and third weeks of gestation were diminished. In the locomotor coordination and the operant conditioning tests, significant differences in the comparison of controls vs. the three treated groups were found, indicating long-term effects of early intoxication upon the central nervous system.

Neurobehavioral Alteration in Rodents Following Developmental Exposure To Aluminum

“…A reduction in birth weight following i.p. (Benett et al, 1975;Cranmer et al, 1986) and oral exposure (Muller et al, 1990;Misawa and Shigeta, 1993) to Al has been reported in the literature.…”

“…However, the time taken to complete each trial was not significantly different between control and treated males from either strain during any of the experiments. Deficits in learning ability following prenatal exposure to Al have been observed in mice (Tsujii and Hoshishima, 1979), rats (Muller et al, 1990;Misawa and Shigeta, 1993) and rabbits (Yokel, 1984), although more recently this latter finding was not confirmed (Yokel et al, 1994).…”

“…Studies in mice (Golub et al, 1987) and in rats (Bemuzzi et al, 1986(Bemuzzi et al, , 1989Muller et al, 1990) did not reveal any disruption of maternal weight gain during gestation. Conversely, Patemain et al (1988) found a decrease in maternal weight gain resulting from exposure of Sprague-Dawley rats to Al nitrate at a dose of 180, 360, or 720 mg/L during days 6-14 of gestation.…”

Effects of Aluminium Chloride Exposure on the Histology of the Cerebral Cortex of Adult Wistar Rats

“…Aluminium was said to have contributed to a variety of cognitive impairments in mice, rabbits, and rat pups (Muller et al, 1990;Yokel, 1985, Bilkei-Gorzo, 1993Mari, 2001). Behavioural impairment has also been reported in wistar rats exposed to soluble aluminium salts (chloride) in the drinking water (Buraimoh et al, 2011b).Both rats (Connor et al, 1988) and mice (Yen-Koo, 1992) have demonstrated such impairments at doses exceeding 200 mg of aluminium per kg of body weight per day.…”

Aggregation-Induced Emission and Applications of Aryl-Substituted Pyrrole Derivatives

“…Aluminum ion (Al 3þ ) is widely used in food additives, kitchen utensils, packing materials, and some Al-based medicines, which increases the risk of Al 3þ entering the human body through the digestive system. It was found many years ago that Al 3þ ions exert several neurotoxic effects in organisms [59][60][61][62][63]. For example, Al 3þ is implicated in Alzheimer's disease, Parkinson's disease, bone softening, chronic renal failure, and smoking-related diseases [64][65][66][67][68][69][70][71][72][73].…”