Developmental analysis of habituation of the acoustic startle response in the preweanling and adult rats

Pletnicov, M V; Сторожева, З. И.; Шерстнев, В. В.

doi:10.1016/0376-6357(95)00004-e

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…6 ), which may be related to the developmental time course of habituation mechanisms. For example, Pletnicov et al. (1995) showed that pre-weanling rats exhibit STH but not LTH of acoustic startle.…”

Section: Discussionmentioning

confidence: 99%

Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations

Haddad

Baines

et al. 2020

Brain, Behavior, & Immunity - Health

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Maternal immune activation (MIA) in response to infection during pregnancy has been linked through various epidemiological and preclinical studies to an increased risk of neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia in exposed offspring. Sensory filtering disruptions occur in both of these disorders and are typically measured using the acoustic startle response in both humans and rodents. Our study focuses on characterizing the baseline reactivity, habituation and prepulse inhibition (PPI) of the acoustic startle response following exposure to MIA. We induced MIA using polyinosinic: polycytidylic acid (poly I:C) at gestational day (GD) 9.5 or 14.5, and we tested sensory filtering phenotypes in adolescent and adult offspring. Our results show that startle reactivity was robustly increased in adult GD9.5 but not GD14.5 poly I:C offspring. In contrast to some previous studies, we found no consistent changes in short-term habituation, long-term habituation or prepulse inhibition of startle. Our study highlights the importance of MIA exposure timing and discusses sensory filtering phenotypes as they relate to ASD, schizophrenia and the poly I:C MIA model. Moreover, we analyze and discuss the potential impact of between- and within-litter variability on behavioural findings in poly I:C studies.

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Section: Discussionmentioning

confidence: 99%

Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations

Haddad

Baines

et al. 2020

Brain, Behavior, & Immunity - Health

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“…Record whether or not the pup moves away from the "cliff" by backing up or by turning sideways. More extensive procedures exist using automated equipment (see Davis, 1984;Schnerson and Willott, 1980;Pletnicov et al, 1995;Martinez et al, 2000; also see UNITS 8.7,8.11A and 8.11B for more extensive tests of the startle response).…”

Section: Negative Geotaxismentioning

confidence: 99%

Assessment of Developmental Milestones in Rodents

2003

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Developmental tests are used to characterize early markers of behavior for investigation of the neurobiology of these behaviors, and to assess the impact of early prenatal or postnatal insult. These perturbations may include pharmacological, environmental, and genetic manipulations. At birth the rat is capable of some specific activities, but its movements are uncoordinated and seemingly random, its tactile sensitivity is not fully developed, and its ear canals and eyes remain closed until several days after birth. Postnatal development consists mainly of the continuation of processes begun earlier. This unit presents protocols for the most commonly used animal tests of developmental reflexology, including negative geotaxis, cliff avoidance, placing responses, tactile and acoustic startle responses, surface and air righting reflexes, crossed extensor reflex, rooting reflex, grasp reflex, bar holding, and horizontal and vertical screen tests.

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“…The reduction in the response can last from minutes to hours depending on the type of stimulus and study conducted. This type of response, often referred to as non-associative learning, has been shown by a variety of organisms from the invertebrates Aplysia, Tritonia, and Drosophila, to rats, using different types of stimuli (Marcus et al, 1988;Pletnikov et al, 1995;Brown, 1998;Cho et al, 2004). One of the prominent behaviors studied in vertebrates is the startle response, a fast contraction of body muscles caused by a sudden acoustic, tactile, or visual stimulus mediated by simple neuronal circuitry (Koch, 1999).…”

Section: Introductionmentioning

confidence: 99%

Non-Associative Learning in Larval Zebrafish

Best¹,

Berghmans²,

Hunt³

et al. 2007

Neuropsychopharmacol

217

150

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Habituation, where a response is reduced when exposed to a continuous stimulus is one of the simplest forms of non-associative learning and has been shown in a number of organisms from sea slugs to rodents. However, very little has been reported in the zebrafish, a model that is gaining popularity for high-throughput compound screens. Furthermore, since most of the studies involving learning and memory in zebrafish have been conducted in adults, we sought to determine if zebrafish larvae could display non-associative learning and whether it could be modulated by compounds identified in previous rodent studies. We demonstrated that zebrafish larvae (7 days post fertilization) exhibit iterative reduction in a startle response to a series of acoustic stimuli. Furthermore, this reduction satisfied criteria for habituation: spontaneous recovery, more rapid reductions in startle to shorter intertrial intervals and dishabituation. We then investigated the pathways mediating this behavior using established compounds in learning and memory. Administration of rolipram (PDE4 inhibitor), donepezil (acetylcholinesterase inhibitor), and memantine (N-methyl-D-aspartic acid (NMDA) receptor antagonist) all increased the acoustic startle response and decreased habituation in the larvae, similar to previous rodent studies. Further studies demonstrated that NMDA blocked the memantine response and the effect of donepezil was blocked by mecamylamine but not atropine suggesting that the donepezil response was mediated by nicotinic rather than muscarinic receptors. Zebrafish larvae possess numerous advantages for medium to high-throughput screening; the model described herein therefore offers the potential to screen for additional compounds for further study on cognition function.

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Developmental analysis of habituation of the acoustic startle response in the preweanling and adult rats

Cited by 10 publications

References 20 publications

Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations

Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations

Assessment of Developmental Milestones in Rodents

Non-Associative Learning in Larval Zebrafish

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