Developmental exposure of bisphenol A induces spatial memory deficits by weakening the excitatory neural circuits of CA3-CA1 and EC-CA1 in mice

Bi, Nanxi; Ding, Jin-Jun; Zou, Rong-Xin; Gu, Xiaozhen; Liu, Zhihua; Wang, Huili

doi:10.1016/j.taap.2021.115641

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…And we speculated that the NLR test might not be the best behavioral paradigm for detecting spatial memory associated with CA1 and CA3. Some studies and our recent results have shown that spatial memory in the Morris water maze or Barnes maze test is mostly related to the CA1 or CA3 regions (Zappa Villar et al, 2018;Bi et al, 2021;Xu et al, 2021). This observation indicated that the NLR test had functional limitations.…”

Section: Discussionmentioning

confidence: 68%

Lateral septal nucleus, dorsal part, and dentate gyrus are necessary for spatial and object recognition memory, respectively, in mice

Jiang

Dong

et al. 2023

Front. Behav. Neurosci.

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IntroductionCognitive impairment includes the abnormality of learning, memory and judgment, resulting in severe learning and memory impairment and social activity impairment, which greatly affects the life quality of individuals. However, the specific mechanisms underlying cognitive impairment in different behavioral paradigms remain to be elucidated.MethodsThe study utilized two behavioral paradigms, novel location recognition (NLR) and novel object recognition (NOR), to investigate the brain regions involved in cognitive function. These tests comprised two phases: mice were presented with two identical objects for familiarization during the training phase, and a novel (experiment) or familiar (control) object/location was presented during testing. Immunostaining quantification of c-Fos, an immediate early gene used as a neuronal activity marker, was performed in eight different brain regions after the NLR or NOR test.ResultsThe number of c-Fos-positive cells was significantly higher in the dorsal part of the lateral septal nucleus (LSD) in the NLR and dentate gyrus (DG) in the NOR experiment group than in the control group. We further bilaterally lesioned these regions using excitotoxic ibotenic acid and replenished the damaged areas using an antisense oligonucleotide (ASO) strategy.DiscussionThese data reinforced the importance of LSD and DG in regulating spatial and object recognition memory, respectively. Thus, the study provides insight into the roles of these brain regions and suggests potential intervention targets for impaired spatial and object recognition memory.

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Section: Discussionmentioning

confidence: 68%

Lateral septal nucleus, dorsal part, and dentate gyrus are necessary for spatial and object recognition memory, respectively, in mice

Jiang

Dong

et al. 2023

Front. Behav. Neurosci.

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“…In addition, according to these authors, maternal exposure to BPA could lead to variations in hippocampal neurotransmitter levels, indicated by a decrease in the glutamic acid/gamma aminobutyric acid (Glu/GABA) ratio in F1 offspring. Bi et al [100] exposed transgenic mice orally to BPA (0.05 mg/kg/day) from postnatal day (PND) 0 to PND 60, subsequently subjecting them to behavioral tests. Their results suggest potentially detrimental effects after BPA exposure on the excitatory neuronal circuitry in spatial memory formation.…”

Section: Developmental and Neurobehavioral Effectsmentioning

confidence: 99%

An Overview of the Health Effects of Bisphenol A from a One Health Perspective

Molina-López

Bujalance-Reyes

Ayala-Soldado

et al. 2023

Animals

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Bisphenol A (BPA) is a chemical compound, considered as an “emerging pollutant”, that appears ubiquitously, contaminating the environment and food. It is an endocrine disruptor, found in a multitude of consumer products, as it is a constituent of polycarbonate used in the manufacture of plastics and epoxy resins. Many studies have evaluated the effects of BPA, using a wide range of doses and animal models. In this work, we carried out a review of relevant research related to the effects of BPA on health, through studies performed at different doses, in different animal models, and in human monitoring studies. Numerous effects of BPA on health have been described; in different animal species, it has been reported that it interferes with fertility in both females and males and causes alterations in their offspring, as well as being associated with an increase in hormone-dependent pathologies. Similarly, exposure to BPA has been related to other diseases of great relevance in public health such as obesity, hypertension, diabetes, or neurodevelopmental disorders. Its ubiquity and nonmonotonic behavior, triggering effects at exposure levels considered “safe”, make it especially relevant when both animal and human populations are constantly and inadvertently exposed to this compound. Its effects at low exposure levels make it essential to establish safe exposure levels, and research into the effects of BPA must continue and be focused from a “One Health” perspective to take into account all the factors that could intervene in the development of a disease in any exposed organism.

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“…As a result, BPA reduced the number of RV + neurons in CA3 and entorhinal cortex but not in the medial septum, decreased the percentage of CaMKIIRV + cells in CA3 hippocampus and entorhinal cortex, and the synaptic connection of upstream glutamatergic neurons and CA1 pyramidal cells was weakened. They concluded that BPA induced detrimental effects on the excitatory neural circuitry of CA3-CA1 and EC-CA1 in memory formation (Bi et al 2021 ). Moreover, the same authors exposed male and female C57BL/6 mice to 1 mg/kg/day of BPA for 10 weeks and observed an aberrant induction of HDAC2 expression.…”

Section: Effects Of Bpa On Animal Modelsmentioning

confidence: 99%

Effect of bisphenol A on the neurological system: a review update

Costa,

Cairrao

2023

Arch Toxicol

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Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins and polycarbonate plastics, which are frequently used in food storage and baby bottles. However, BPA can bind mainly to estrogen receptors, interfering with various neurologic functions, its use is a topic of significant concern. Nonetheless, the neurotoxicity of BPA has not been fully understood despite numerous investigations on its disruptive effects. Therefore, this review aims to highlight the most recent studies on the implications of BPA on the neurologic system. Our findings suggest that BPA exposure impairs various structural and molecular brain changes, promoting oxidative stress, changing expression levels of several crucial genes and proteins, destructive effects on neurotransmitters, excitotoxicity and neuroinflammation, damaged blood–brain barrier function, neuronal damage, apoptosis effects, disruption of intracellular Ca2+ homeostasis, increase in reactive oxygen species, promoted apoptosis and intracellular lactate dehydrogenase release, a decrease of axon length, microglial DNA damage, astrogliosis, and significantly reduced myelination. Moreover, BPA exposure increases the risk of developing neurologic diseases, including neurovascular (e.g. stroke) and neurodegenerative (e.g. Alzheimer’s and Parkinson’s) diseases. Furthermore, epidemiological studies showed that the adverse effects of BPA on neurodevelopment in children contributed to the emergence of serious neurological diseases like attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), depression, emotional problems, anxiety, and cognitive disorders. In summary, BPA exposure compromises human health, promoting the development and progression of neurologic disorders. More research is required to fully understand how BPA-induced neurotoxicity affects human health.

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Developmental exposure of bisphenol A induces spatial memory deficits by weakening the excitatory neural circuits of CA3-CA1 and EC-CA1 in mice

Cited by 12 publications

References 33 publications

Lateral septal nucleus, dorsal part, and dentate gyrus are necessary for spatial and object recognition memory, respectively, in mice

Lateral septal nucleus, dorsal part, and dentate gyrus are necessary for spatial and object recognition memory, respectively, in mice

An Overview of the Health Effects of Bisphenol A from a One Health Perspective

Effect of bisphenol A on the neurological system: a review update

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