Developmental expression and distribution of nesfatin-1/NUCB2 in the canine digestive system

Jiang, Shudong; WeiJuan, Zhou; Zhang, Xingwang; DengFeng, Wang; Zhu, Huaqiang; Hong, Meizhen; Gong, Yu; Ye, Jing; Fang, Fugui

doi:10.1016/j.acthis.2015.11.010

Cited by 19 publications

(11 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 5 Subsequent studies have shown that nesfatin-1 is widely expressed in other regions of the brain also, like brainstem, including dorsal vagal complex (DVC), Edinger-Westphal nucleus, locus coeruleus (LC), lateral parabrachial nucleus, ventrolateral medulla (VLM), 10 , 11 insular cortex, central amygdala, ventrolateral medulla, cerebellar Purkinje cell, pterygopalatine parasympathetic preganglionic neurons, and spinal cord at the lumbar and sacral region. 11 In addition to being widely expressed in the central nervous system, nesfatin-1 is also expressed in peripheral tissues, like esophagus, 12 stomach, small intestine, 13 colon, pancreas, 14 liver, adipocytes, 15 cardiomyocytes, 16 testes, 17 ovaries, 18 uterus and epididymis. 19…”

Section: Structure and Localization Of Nesfatin-1mentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

View full text Add to dashboard Cite

Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

show abstract

Section: Structure and Localization Of Nesfatin-1mentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

View full text Add to dashboard Cite

show abstract

“…Recent studies showed that a large amount of the nesfatin-1 expression was detected in the digestive system as well as in the brain. It has also been reported that the nesfatin-1 generated in the gastric organs, by acting in the brain, reduces food intake and suppresses the motilities of the stomach-duodenum (Prinz et al, 2016; Jiang et al, 2016). Nesfatin-1 immunoreactive cells are also co-localized with insulin in pancreatic beta-cells of mice and rats, suggesting a potential role for nesfatin-1 in pancreatic islet and glucose homeostasis (Shimizu & Osaki, 2014; Gonzalez et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Testosterone Regulates NUCB2 mRNA Expression in Male Mouse Hypothalamus and Pituitary Gland

Seon¹,

Jeon²,

Kim³

et al. 2017

Dev Reprod

View full text Add to dashboard Cite

Nesfatin-1/NUCB2 is known to take part in the control of the appetite and energy metabolism. Recently, many reports have shown nesfatin-1/NUCB2 expression and function in various organs. We previously demonstrated that nesfatin-1/NUCB2 expression level is higher in the pituitary gland compared to other organs and its expression is regulated by 17β-estradiol and progesterone secreted from the ovary. However, currently no data exist on the expression of nesfatin-1/NUCB2 and its regulation mechanism in the pituitary of male mouse. Therefore, we examined whether nesfatin-1/NUCB2 is expressed in the male mouse pituitary and if its expression is regulated by testosterone. As a result of PCR and western blotting, we found that a large amount of nesfatin-1/NUCB2 was expressed in the pituitary and hypothalamus. The NUCB2 mRNA expression level in the pituitary was decreased after castration, but not in the hypothalamus. In addition, its mRNA expression level in the pituitary was increased after testosterone treatment in the castrated mice, whereas, the expression level in the hypothalamus was significantly decreased after the treatment with testosterone. The in vitro experiment to elucidate the direct effect of testosterone on NUCB2 mRNA expression showed that NUCB2 mRNA expression was significantly decreased with testosterone in cultured hypothalamus tissue, but increased with testosterone in cultured pituitary gland. The present study demonstrated that nesfatin-1/NUCB2 was highly expressed in the male mouse pituitary and was regulated by testosterone. This data suggests that reproductive-endocrine regulation through hypothalamus-pituitary-testis axis may contribute to NUCB2 mRNA expression in the mouse hypothalamus and pituitary gland.

show abstract

“…In pigs, nesfatin-1 immunoreactivity was described in the entire the gastrointestinal tract with localization in the endocrine cells of the gastric fundus, duodenum, ileum, ileocecal valve, and colon (25). In dogs, nesfatin-1 was only detected in the stomach and pancreas, but nesfatin-1 mRNA was detected in the entire gastrointestinal tract (13). Obestatin and ghrelin are present in the stomach, duodenum, jejunum, colon, and pancreas (7,9,14,30).…”

Section: Resultsmentioning

confidence: 99%

Immunohistochemical localization of adropin in the small intestine of rats

Pawłowska-Olszewska¹,

Puzio²,

Kapica³

et al. 2019

Medycyna Weterynaryjna

View full text Add to dashboard Cite

The aim of this study was to determine the occurrence and distribution of adropin in the small intestine in control and gastrectomized rats. The study was carried out on 12 Wistar rats. Six control rats (SHO) underwent a sham operation. Six rats were subjected to gastrectomy (Gx); i.e. resection of the antrum and the glandular part of the stomach. Six weeks after the surgery, the rats were sacrificed. The duodenum and middle part of the jejunum were collected for immunohistochemical and immunofluorescence procedures. An immunopositive reaction to ADR was detected in the duodenum and jejunum, in crypts, and in enterocytes located along the entire length of the villi. Furthermore, more intense ADR immunoreactivity was observed in the crypts and villi of the duodenum than in the jejunum. The presence of adropin was also detected in the submucosa and muscularis externa of the duodenum and jejunum, in the cells of Brunner’s gland of the duodenum, and in myenteric and submucosal plexus nerve. The ADR immunoreactivity in the crypts and villi in the duodenum and jejunum was lower in the Gx rats compared to the SHO rats. The ADR distribution in the duodenum and jejunum has also been confirmed in immunofluorescence studies. In conclusion, our data demonstrated ADR expression in all histological layers of the small intestine in the rats. Gx reduced ADR immunoreactivity in the crypts and enterocytes. This may suggest a potential impact of ADR on intestine function such as absorbability and immune reactions. However, further research is needed to explain the ADR role in gastrointestinal functions

show abstract

Developmental expression and distribution of nesfatin-1/NUCB2 in the canine digestive system

Cited by 19 publications

References 27 publications

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Testosterone Regulates NUCB2 mRNA Expression in Male Mouse Hypothalamus and Pituitary Gland

Immunohistochemical localization of adropin in the small intestine of rats

Contact Info

Product

Resources

About