Developmental gene expression of gastrin receptor in rat stomach

Identification and regulation of the gastric H+/K+‐ATPase in the rat heart

“…A bi‐phasic change, with a significant reduction in the expression level from 1 to 3 weeks after birth and a return to neonatal level 75 days after birth was detected. This bi‐phasic change of H + /K + ‐ATPase mRNA has also been found in rat stomach (Wang et al. 1997b), which complies with reports indicating presence of gastric acid secretion during the foetal period (Yee et al.…”

Quantitative measurement of mRNA coding for the receptors controlling acid secretion in the ovine fundus and antrum by using RT‐PCR

“…Fetal mRNA levels were not determined. Wang et al demonstrated an increase in CCK B/GR expression 6 h after injection of pentagastrin to 3‐day‐old rats 25 . However, this was at a time of low antral gastrin expression and secretion and no detectable labeled gastrin binding 32,39 .…”

“…However, the elevated levels of fetal plasma gastrin suggests that the inhibitory effect of somatostatin is not dominant in the fetus. Little is known about the developmental profile of receptors regulating gastric acidity, although Wang et al recently demonstrated CCK B/gastrin receptor mRNA in the neonate and adult rat stomach with much lower levels in the fetus 25 …”