Developmental Hemostasis

Monagle, Paul; Hagstrom, J. Nathan

doi:10.1016/b978-0-7216-9654-6.50151-x

Cited by 6 publications

(6 citation statements)

References 114 publications

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“…Fibrinogen has previously been demonstrated to exist in a 'fetal' form, in cord blood of term infants [5]. This 'fetal' fibrinogen was shown to have increased sialic acid content compared to adult fibrinogen, a direct result of posttranslational modification (PTM).…”

Section: Introductionmentioning

confidence: 98%

Evidence for age-related differences in human fibrinogen

Ignjatović

Ilhan

Monagle

2011

Blood Coagulation &Amp; Fibrinolysis

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Fibrinogen has previously been demonstrated to exist in a 'fetal' form, in cord blood of term infants, with increased sialic acid content compared to adult fibrinogen. The functional implications of these differences are reflected in prolonged thrombin clotting times in newborns as well as differences in polymerization of fibrin from 'fetal' fibrinogen. Despite numerous studies of fibrinogen structure and function, the age at which 'fetal' fibrinogen reverts to the adult form, as well as the physiological significance of this phenomenon remains unknown. This study was designed to determine whether the difference between the 'fetal' and the 'adult' fibrinogen molecule persists in a 'childhood' form throughout progression from infancy to adulthood. The results demonstrate that although the concentration of fibrinogen from day 1 neonates is decreased compared to adult fibrinogen, functional activity of this protein is comparable in both age groups. In addition, despite there being quantitatively less fibrinogen in day 3 and 11-16-year age groups, this protein is functionally more active compared to adult fibrinogen. In addition, the molecular weight of the Aα fibrinogen chain was consistently higher by up to 1500 Da in neonates and children compared to adults, suggesting age-specific differences in posttranslational modification of this chain of the protein.These age-related differences in fibrinogen could provide a protective mechanism against excessive polymerization and proteolysis of this protein, providing a possible explanation of the thromboprotective mechanism that is functioning in neonates and children.

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Section: Introductionmentioning

confidence: 98%

Evidence for age-related differences in human fibrinogen

Ignjatović

Ilhan

Monagle

2011

Blood Coagulation &Amp; Fibrinolysis

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“…[2][3][4] However, coagulation proteins have complex tertiary structures, which in general bestow multiple functions. 9,10 Posttranslational modifications (PTM) affecting the structure of hemostatic proteins are known to occur and likely have significant impact on the function of these proteins. 9,10 As an example, fibrinogen has previously been demonstrated to exist in a ''fetal'' form, in cord blood of term infants.…”

mentioning

confidence: 99%

“…9,10 Posttranslational modifications (PTM) affecting the structure of hemostatic proteins are known to occur and likely have significant impact on the function of these proteins. 9,10 As an example, fibrinogen has previously been demonstrated to exist in a ''fetal'' form, in cord blood of term infants. 10 This ''fetal'' fibrinogen was shown to have increased sialic acid content compared with adult fibrinogen, a direct result of PTM.…”

mentioning

confidence: 99%

“…9,10 As an example, fibrinogen has previously been demonstrated to exist in a ''fetal'' form, in cord blood of term infants. 10 This ''fetal'' fibrinogen was shown to have increased sialic acid content compared with adult fibrinogen, a direct result of PTM. Moreover, the phosphorus content of fetal fibrinogen is increased up to fourfold compared with the adult form of this protein.…”

mentioning

confidence: 99%

“…In addition, developmental hemostasis could also reflect the role that hemostatic proteins play in physiological development and hence the demand of other processes, such as angiogenesis. 10 Finally, without doubt, developmental hemostasis affects the interactions of anticoagulant drugs with the coagulation system. This article will discuss the coagulation system during childhood in light of these three aspects and suggest possible strategies to further understand this complex and exciting field of study.…”

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confidence: 99%

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The Coagulation System in Children: Developmental and Pathophysiological Considerations

Ignjatović

Mertyn

Monagle

2011

Semin Thromb Hemost

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The coagulation system in children is complex and ever changing, a fact encapsulated in the term developmental hemostasis. Studies confirm that there are quantitative and almost certainly qualitative differences in the coagulation system with age, and the control of these changes comes from something external to the liver. What remains uncertain is the magnitude of the qualitative changes and the implications of the changes for the growing child. At the very least, developmental hemostasis probably provides a protective mechanism for neonates and children and hence contributes to the decreased risk of thromboembolic and/or hemorrhagic events in these age groups. In addition, developmental hemostasis could also reflect the role that hemostatic proteins play in physiological development and hence the demand of other processes, such as angiogenesis. Finally, without doubt, developmental hemostasis affects the interactions of anticoagulant drugs with the coagulation system. This article will initially discuss the most recent evidence with respect to qualitative age-related changes in the coagulation system. Subsequently the article will discuss the coagulation system during childhood in light of the three aforementioned areas of clinical impact and suggest possible strategies to further understand this complex and exciting field of study.

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Does prematurity affect thrombocytopoiesis?

et al. 2007

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Data concerning thrombocytopoiesis in newborns are poorly recognized. Platelets have a crucial role in hemostatic physiology, which is deficient in newborns, especially in preterm newborns. A total of 51 preterm newborns (PTN), 25 girls and 26 boys, were recruited for the study. The control group consisted of 25 female and 30 male healthy term newborns (HTN). Plasma thrombopoietin (TPO) was measured using Quantikine human TPO system. Reticulated platelets (PLRET) was estimated by means of Retic-Count Kit. Platelet count (PLT) was determined using Advia(TU) 120 Hematology System. TPO was evidently higher in PTN (110.9 pg/ml) than in HTN (71.5 pg/ml), (p < 0.001). The percentage of reticulated platelets (PLRET) was also twice as high in PTN (3.49%) in comparison to HTN (1.7%), (p < 0.001). The PLT count was lower in PTN (246.7 x 10(3) microL) than in HTN (287.2 x 10(3) microL), (p < 0.01). Increased TPO levels and the percentage of PLRET indicate that thrombocytopoiesis is more active in prematurity. Our finding may be useful in therapeutic strategies.

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Developmental Hemostasis

Cited by 6 publications

References 114 publications

Evidence for age-related differences in human fibrinogen

Evidence for age-related differences in human fibrinogen

The Coagulation System in Children: Developmental and Pathophysiological Considerations

Does prematurity affect thrombocytopoiesis?

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