Developmental Lead Exposure in Rats Causes Sex-Dependent Changes in Neurobiological and Anxiety-Like Behaviors that Are Improved by Taurine Co-treatment

Taurine Supplementation for 48-Months Improved Glucose Tolerance and Changed ATP-Related Enzymes in Avians

“…These differences in the glucose metabolism and muscle enzyme levels in response to taurine in avians suggest that the AMS may need to be reevaluated for its utility as a preclinical model for medical diseases. In recent years, a new body of research is being reported on a broad range of taurine therapeutics and bioenergetics in regulating: oligodendrocytes in neuropathophysiological conditions [25], bioenergetics of the mitochondria in the brain [26], neuroprotection in aged rats [27], how the brain responds to stress and posttraumatic stress disorderlike symptoms in rats [28], recovering frontoexecutive functions and anxiety-like behaviors in lead poisoned rats [29][30][31][32][33][34][35], mitigating against brain excitability and epilepsy [36], to bioenergetic adaptations in skeletal muscle function [37], its ability to influence motor learning following oral supplementation [38], its sex-dependent influences on rat's active avoidance learning processes [39], the way rats respond to resistance training [40] and even in humans in runner adaptations to running trails [41] and improving power during severe and intense exercise [42]. This rich emerging literature will certainly guide the field in next approaches to improving our understanding of the tradeoffs between taurine bioenergetics and therapeutics across different model systems [43,44].…”