Developmental Origins of Cardiovascular Disease

Yeung, Edwina; Robledo, Candace; Boghossian, Nansi S.; Zhang, Cuilin; Mendola, Pauline

doi:10.1007/s40471-014-0006-4

Cited by 28 publications

(36 citation statements)

References 90 publications

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“…Incipient hypertensive patients, elderly hypertensive patients, or obese hypertensive patients; infants with birth weight <3.05 kg, 17,18 or premature infants (gestational age <37 weeks), 19,20 or infants with macrosomia (birth weight >4.0 kg) 21…”

Section: Hypertensive Population Recommended Salt Assessmentmentioning

confidence: 99%

“…Incipient hypertensive patients, elderly hypertensive patients, or obese hypertensive patients; infants with birth weight <3.05 kg, or premature infants (gestational age <37 weeks), or infants with macrosomia (birth weight >4.0 kg); resistant hypertensive patients; women with a history of hypertensive disorder complicating pregnancy; hypertensive patients with high nocturnal blood pressure (nondipper blood pressure except obstructive sleep apnea syndrome) accompanied by fast nocturnal heart rate (average heart rate >75 beats/min); hypertensive patients with a family history of cardiovascular and cerebrovascular diseases, or hypertensive patients living in the northern part of China whose blood pressure does not reach the target with a single drug; and patients with chronic kidney disease (CKD).…”

Section: Introductionmentioning

confidence: 99%

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An expert recommendation on salt intake and blood pressure management in Chinese patients with hypertension: A statement of the Chinese Medical Association Hypertension Professional Committee

Sun

2019

J of Clinical Hypertension

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The occurrence of hypertension is influenced by combined actions of genetic and environmental factors. Among environmental factors, high salt intake is considered as one of the most important and critical dietary factors. High salt intake is closely related to the incidence and mortality of cardiac and cerebrovascular events, as well as ventricular hypertrophy, renal damage, and other target organ damages. The existing data show that the daily sodium salt intake of Chinese population is significantly higher than that of European and American populations, and it generally exceeds the standard. Therefore, sodium and potassium intake in patients with hypertension should be actively assessed to carry out targeted treatment, which is an important strategy in blood pressure management. According to the characteristics of high prevalence of hypertension, high sodium salt intake, and low blood pressure control rate in China, Chinese Medical Association Hypertension Professional Committee believes that it is necessary to promote salt restriction and formulate the assessment of salt intake and clinical process of blood pressure management according to the current status of sodium intake.

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Section: Hypertensive Population Recommended Salt Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An expert recommendation on salt intake and blood pressure management in Chinese patients with hypertension: A statement of the Chinese Medical Association Hypertension Professional Committee

Sun

2019

J of Clinical Hypertension

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“…; Yeung et al . ; Langley‐Evans, ). However, much less is known about the effects of this important programming challenge directly on the heart.…”

Section: Introductionmentioning

confidence: 99%

Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing

Kuo

et al. 2016

The Journal of Physiology

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Extensive rodent studies have shown that reduced perinatal nutrition programmes chronic cardiovascular disease. To enable translation to humans, we developed baboon offspring cohorts from mothers fed ad libitum (control) or 70% of the control ad libitum diet in pregnancy and lactation, which were growth restricted at birth. We hypothesized that intrauterine growth restriction (IUGR) offspring hearts would show impaired function and a premature ageing phenotype. We studied IUGR baboons (8 male, 8 female, 5.7 years), control offspring (8 male, 8 female, 5.6 years - human equivalent approximately 25 years), and normal elderly (OLD) baboons (6 male, 6 female, mean 15.9 years). Left ventricular (LV) morphology and systolic and diastolic function were evaluated with cardiac MRI and normalized to body surface area. Two-way ANOVA by group and sex (with P < 0.05) indicated ejection fraction, 3D sphericity indices, cardiac index, normalized systolic volume, normalized LV wall thickness, and average filling rate differed by group. Group and sex differences were found for normalized LV wall thickening and normalized myocardial mass, without interactions. Normalized peak LV filling rate and diastolic sphericity index were not correlated in control but strongly correlated in OLD and IUGR baboons. IUGR programming in baboons produces myocardial remodelling, reduces systolic and diastolic function, and results in the emergence of a premature ageing phenotype in the heart. To our knowledge, this is the first demonstration of the specific characteristics of cardiac programming and early life functional decline with ageing in an IUGR non-human primate model. Further studies across the life span will determine progression of cardiac dysfunction.

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“…Evidence linking preexisting maternal medical conditions and pregnancy complications with maternal and child health over the life-course (Malcolm 2012; Brown et al 2013; Ray et al 2001; Yeung et al 2014) is fueling an interest to uncover their underlying causes and effects. Consequently, there is a demand for data sources that can accurately ascertain outcomes during pregnancy such as gestational diabetes, cardiovascular disease and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Examining the Prevalence Rates of Preexisting Maternal Medical Conditions and Pregnancy Complications by Source: Evidence to Inform Maternal and Child Research

Robledo

Yeung

Mendola

et al. 2016

Matern Child Health J

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Objectives We sought to examine whether there are systematic differences in ascertainment of preexisting maternal medical conditions and pregnancy complications from three common data sources used in epidemiologic research. Methods Diabetes mellitus, chronic hypertension, gestational diabetes mellitus (GDM), gestational hypertensive disorders (GHD), placental abruption and premature rupture of membranes (PROM) among 4821 pregnancies were identified via birth certificates, maternal self-report at approximately 4 months postpartum and by discharge codes from the Statewide Planning and Research Cooperative System (SPARCS), a mandatory New York State hospital reporting system. The kappa statistic (k) was estimated to ascertain beyond chance agreement of outcomes between birth certificates with either maternal self-report or SPARCS. Results GHD was under-ascertained on birth certificates (5.7 %) and more frequently indicated by maternal report (11 %) and discharge data (8.2 %). PROM was indicated more on birth certificates (7.4 %) than maternal report (4.5 %) or discharge data (5.7 %). Confirmation across data sources for some outcomes varied by maternal age, race/ethnicity, prenatal care utilization, preterm delivery, parity, mode of delivery, infant sex, use of infertility treatment and for multiple births. Agreement between maternal report and discharge data with birth certificates was generally poor (kappa < 0.4) to moderate (0.4 ≤ kappa < 0.75) but was excellent between discharge data and birth certificates for GDM among women who underwent infertility treatment (kappa = 0.79, 95 % CI 0.74, 0.85). Conclusions for Practice Prevalence and agreement of conditions varied across sources. Condition-specific variations in reporting should be considered when designing studies that investigate associations between preexisting maternal medical and pregnancy-related conditions with health outcomes over the life-course.

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Developmental Origins of Cardiovascular Disease

Cited by 28 publications

References 90 publications

An expert recommendation on salt intake and blood pressure management in Chinese patients with hypertension: A statement of the Chinese Medical Association Hypertension Professional Committee

An expert recommendation on salt intake and blood pressure management in Chinese patients with hypertension: A statement of the Chinese Medical Association Hypertension Professional Committee

Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing

Examining the Prevalence Rates of Preexisting Maternal Medical Conditions and Pregnancy Complications by Source: Evidence to Inform Maternal and Child Research

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