Developmental Orthopedic Disease

Demko, Jennifer L.; McLaughlin, Richard A.

doi:10.1016/j.cvsm.2005.05.002

Cited by 63 publications

(72 citation statements)

References 63 publications

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“…It is a developmental disorder of the coxo-femoral joint in which excessive looseness and malcongruency of the joint structures leads in many cases to debilitating osteoarthritis in one or both hips [2]–[4]. The mode of inheritance of CHD is multifactorial, meaning that many genes and many non-genetic factors contribute to variation in the CHD phenotype.…”

Section: Introductionmentioning

confidence: 99%

Estimated Breeding Values for Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

et al. 2013

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Canine hip dysplasia (CHD) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority. The typical heritability estimates for radiographic CHD traits suggest that the accuracy of breeding dog selection could be substantially improved by the use of estimated breeding values (EBVs) in place of selection based on phenotypes of individuals. The British Veterinary Association/Kennel Club scoring method is a complex measure composed of nine bilateral ordinal traits, intended to evaluate both early and late dysplastic changes. However, the ordinal nature of the traits may represent a technical challenge for calculation of EBVs using linear methods. The purpose of the current study was to calculate EBVs of British Veterinary Association/Kennel Club traits in the Australian population of German Shepherd Dogs, using linear (both as individual traits and a summed phenotype), binary and ordinal methods to determine the optimal method for EBV calculation. Ordinal EBVs correlated well with linear EBVs (r = 0.90–0.99) and somewhat well with EBVs for the sum of the individual traits (r = 0.58–0.92). Correlation of ordinal and binary EBVs varied widely (r = 0.24–0.99) depending on the trait and cut-point considered. The ordinal EBVs have increased accuracy (0.48–0.69) of selection compared with accuracies from individual phenotype-based selection (0.40–0.52). Despite the high correlations between linear and ordinal EBVs, the underlying relationship between EBVs calculated by the two methods was not always linear, leading us to suggest that ordinal models should be used wherever possible. As the population of German Shepherd Dogs which was studied was purportedly under selection for the traits studied, we examined the EBVs for evidence of a genetic trend in these traits and found substantial genetic improvement over time. This study suggests the use of ordinal EBVs could increase the rate of genetic improvement in this population.

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Section: Introductionmentioning

confidence: 99%

Estimated Breeding Values for Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

et al. 2013

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“…For the authors, it is not typical to find a canine elbow joint affected with severe OC of the medial humeral condyle and FMCP with moderate radiographic progression of OA at the 90 th post-operative day, as it was observed in this case. It is well recognized that the prognosis for medical or surgical treatment of a canine elbow affected by OC is guarded, because OA progression remains as an inevitable sequel (Demko and McLaughlin 2005).…”

Section: Resultsmentioning

confidence: 99%

“…CED is a common cause of forelimb lameness and occurs frequently in 4-6 month old dogs from medium to large body size. The etiology and pathogenesis of CED is not completely understood, although genetics, either nutritional excesses or deficiencies, growth disturbances, OC and, trauma are proposed causes (Demko and McLaughlin 2005). To date, CED is managed by combining the specific surgical treatment in conjunction with diminution of the body weight, physiotherapy and administration of oral non-steroidal anti-inflammatory drugs and nutraceutical agents (Beale 2004).…”

Section: Introductionmentioning

confidence: 99%

Use of intra-articular autologous platelet concentrates as coadjutants in the surgical arthroscopy treatment of elbow dysplasia in a bitch

2013

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“…Es kann im Abstand von einigen Wochen oder Monaten immer wieder zu Krankheitssch ü ben kommen. Eine vermehrte Belastung der erkrankten Hunde f ü hrt zu einer Verst ä rkung der Symptomatik [9] . Die Ä tiologie dieser Erkrankung ist nicht vollst ä ndig gekl ä rt, sicher scheint, dass die F ü tterung, insbesondere der Protein-und Energiegehalt des Futters, eine Rolle spielt.…”

Section: Fall Nr 4: Panostitisunclassified

Einsatz der Skelettszintigrafie in der Lahmheitsdiagnostik beim Kleintier

Bolln

Franke

2010

Der Nuklearmediziner

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Zusammenfassung Zur Lahmheitsdiagnostik beim Kleintier hat sich die Skelettszintigrafie als geeignete Methode erwiesen. Sie ist eine sensitive, nichtinvasive Methode, um Knochenläsionen darzustellen. Sie ermöglicht eine funktionelle Darstellung des Skeletts und damit eine frühzeitige Lokalisation und Diagnose bei unklaren Lahmheiten. Einer der wesentlichen Unterschiede zur humanmedizinischen Diagnostik ist, dass ein Tier nicht in der Lage ist, die Art seiner Schmerzen dem Untersucher mitzuteilen. Dazu kommt die fehlende Kooperationsbereitschaft des Tieres bei der Durchführung der Szintigrafie. Vor diesem Hintergrund werden anhand von 5 Beispielen die Vorteile, die Durchführbarkeit und die verschiedenen Indikationen für eine Skelettszintigrafie dargestellt. Die Technik der Untersuchung orientiert sich an den humanmedizinischen Protokollen einer 2-Phasen-Skelettszintigrafie und muss in Narkose durchgeführt werden, um Bewegungsartefakte während der Akquisition auszuschließen. Die Autoren sehen die Skelettszintigrafie als sinnvolles Diagnostikum in der Lahmheitsuntersuchung beim Kleintier, welches richtungsweisend für eine schnelle Diagnose und damit gezielte Therapie ist. So können Sekundärschäden und unnötige Kosten für den Besitzer minimiert werden.

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Developmental Orthopedic Disease

Cited by 63 publications

References 63 publications

Estimated Breeding Values for Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

Estimated Breeding Values for Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

Use of intra-articular autologous platelet concentrates as coadjutants in the surgical arthroscopy treatment of elbow dysplasia in a bitch

Einsatz der Skelettszintigrafie in der Lahmheitsdiagnostik beim Kleintier

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