Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium

Back, Peter; Walter, Klaus

doi:10.1016/0016-5085(80)90666-6

Cited by 133 publications

(49 citation statements)

References 18 publications

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“…The reports of use of ursodeoxycholic acid in extrahepatic biliary atresia lacked assessment of level of lithocholic acid levels according to ursodeoxycholic acid intake. Moreover, in the neonatal period, the hepatic glucuronidation, sulfation of bile acids, and different enzyme activity were reported to be low [28,29]. Owing to the cited differences among neonates and adults, a successful adult model is not evidence that same model is applicable to newborns and infants by example.…”

Section: Discussionmentioning

confidence: 86%

Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia

Kotb

2008

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 86%

Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia

Kotb

2008

Journal of Pediatric Surgery

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“…During liver disfunction bile acid metabolism may become further modified to yield unusual tetrahydroxylated bile acids (Back and Walter 1980a) which also appear in urine (Bremmelgaard and Sj6vall 1980). Multihydroxylated bile acids are also found in fetal meconium (Back and Walter 1980b). Fetal bile acids differ from those in the adult in the total amount and in the location and epimeric position of hydroxyl groups, in the carbon length of the C17 alkyl side chain, and in additional keto-groups.…”

Section: Biliary Clearancementioning

confidence: 95%

Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport

Petzinger¹

1994

Reviews of Physiology, Biochemistry and Pharmacology

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“…All of them showed increased medullar hematopoiesis when compared to control group. Since DCA can cross placental barrier [3], it is possible that the toxic effects caused by the ingestion of CA are due to DCA of maternal origin.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, fetal and neonatal bile metabolism is different from the adult one, as comparative studies performed in bile, meconium, urine, and serum have demonstrated [2][3][4][5]. The patients with biliary atresia and NH may present ''atypical'' BA and changes in the BA metabolism [6].…”

Section: Introductionmentioning

confidence: 94%

Hepatobiliary effects of cholic and lithocholic acids: experimental study in hamsters

et al. 2007

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Etiopathogenesis of biliary atresia remains unknown. Among several theories, one proposes that the disorder may be caused by the toxic effect of monohydroxy bile acids on fetal and neonatal hepatobiliary system. In this paper we evaluated toxic effects produced by ingestion of cholic acid, a trihydroxy bile acid, and lithocholic acid, a monohydroxy bile acid in the hepatobiliary system of a hamster during gestational and perinatal periods. A diet composed by 0.5% cholic acid and 0.25% lithocholic acid was administrated to pregnant hamsters. Liver and bile ducts of the adult and newborn animals were analyzed to point out the changes induced by these acids after birth. Because hamsters and humans have a similar bile metabolism, these animals were eligible for the study. The ingestion of 0.5% lithocholic acid, during hamster's gestation, caused maternal intense ductal/ductular proliferation, inflammatory signs, hepatic cells degeneration and regeneration, hyperplasia of extra hepatic ducts epithelium, and abortion. Both 0.5% cholic acid and 0.25% lithocholic acid ingested by pregnant hamsters, caused ductal/ductular proliferation and hepatobiliary inflammatory damage in a different degree of intensity in adult animals and mild intensity in the young; and also the number of the young was reduced in the litter. We found that the ingestion of these bile acids by hamsters, during gestational period caused different degrees of toxicity on maternal and neonatal hepatobiliary systems. The histopathologic findings observed in biliary atresia patients could not be found in newborn hamsters. New experimental models are needed in the attempt to establish a correlation of these acids with neonatal cholestatic diseases.

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Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium

Cited by 133 publications

References 18 publications

Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia

Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia

Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport

Hepatobiliary effects of cholic and lithocholic acids: experimental study in hamsters

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