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Details of the novel method of laser desorption with a low powered IR-laser and resonance-enhanced multiphoton ionization (REMPI) combined with a high-resolution Reflectron-Time-of-Flight (RETOF) mass spectrometer are explained. Different features of the method are discussed. Some results of mass spectrometric investigations of biomolecules are shown.

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We show here that 'double-barrelled' laser desorptionJresonance-enhanced multi-photon ionization mass spectrometry has many advantages over traditional single-step desorptionJionuation techniques, particularly if combined with Reflectron-Time-of-Flight mass analysers. We demonstrate the effectiveness of this technique for large labile biomolecules, namely native chlorophylls, porphyrins and a peptide, as examples of structural and mass analysis.