Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells

Facer, P.; Bishop, Anne E.; Cole, G.; Aitchison, Michael; Kendall, C H; Aswegen, G. Van; Penketh, Richard; Rodek, C.; McKeever, Paul E.; Polak, Julia M.

doi:10.1016/0016-5085(89)91414-5

Cited by 44 publications

(16 citation statements)

References 39 publications

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“…EC cells in the intestine begin to synthesize 5HT at early embryonic stage [3,7] and the present result showed that antigenicity is well preserved even though the section are treated with DAB-nickel reactions [18]. In the present results, most of the EC cells obtained a large number of immunogold particles with no DAB-nickel reaction products in the cytoplasm.…”

Section: Discussionsupporting

confidence: 64%

Immuno-electron Microscopic Demonstration of Luminal Release of Serotonin from Enterochromaffin Cells of Rat Embryo.

Fujimiya

Okumiya

Maeda

1995

Acta Histochem. Cytochem

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Section: Discussionsupporting

confidence: 64%

Immuno-electron Microscopic Demonstration of Luminal Release of Serotonin from Enterochromaffin Cells of Rat Embryo.

Fujimiya

Okumiya

Maeda

1995

Acta Histochem. Cytochem

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“…Development-related changes of several gastrointestinal hormones have already been described (Alumets et al 1983;Facer et al 1989;Krause et al 1989;Zabel et al 1995;El-Salhy and Sandström 1999;Lucini et al 1999;Sandström and El-Salhy 1999). However, most of these studies were conducted in small laboratory animals that differ in many aspects from higher mammalian species (Krause et al 1989;El-Salhy and Sandström 1999).…”

Section: Discussionmentioning

confidence: 90%

A stereologic evaluation of glucagon-like peptide-1 (GLP-1) mucosal cells in the small intestine of the developing pig

et al. 2002

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Studies that investigate possible developmental changes in gastrointestinal hormones in the pig are sparse and contradictory. Therefore, a quantitative morphological study using stereologic methods on paraffin sections of the different small intestinal regions (cranial and caudal duodenum, jejunum and ileum) of the developing pig (second half of the gestation, neonatal and weaning period) has been conducted. The sections were processed for GLP-1-immunohistochemistry. During the investigated time span, the volume of GLP-1-IR cells increased approximately 40-fold in both the jejunum and ileum, notwithstanding a decrease of their volume density. The ileal small intestinal segment contained the highest volume density of GLP-1-IR cells. In contrast, GLP-1-IR cells were only occasionally encountered in the duodenum. The development-related changes of the investigated parameters coincide with dietary changes and the regional differences are in accordance with functional reports that point to GLP-1 as a gastrointestinal hormone that ediates the 'ileal brake' and stimulates glucose-dependent pancreatic insulin secretion.

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“…This current study shows that gastrin and PYY significantly vary with gestational age, suggesting that there may be a temporal association of peptide concentrations and intestinal motility. Facer (10) has shown that fetal small intestine cell numbers of gastrin, GIP, and PYY increase with gestational age. We have recently shown that fasting gastrin concentration is significantly predictive of maturation of intestinal motility patterns in preterm infants (1 1).…”

Section: Discussionmentioning

confidence: 99%

Responses of Gastrointestinal Peptides and Motor Activity to Milk and Water Feedings in Preterm and Term Infants

et al. 1992

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ABSTRACT. Because duodenal motor activity differs between preterm and term infants during fasting, this study evaluated the responses of motor activity and peptide release in response to feeding. In the first study, fasting concentrations of gastrin, gastric inhibitory peptide, neurotensin, and peptide W ( P W ) were determined in 5 3 preterm and 20 term infants. Plasma concentrations of gastrin and neurotensin were significantly lower in preterm infants than in healthy adults reported previously by our lab ( p < 0.01). Plasma concentration of gastric inhibitory peptide and P W were higher than in healthy adults ( p < 0.01). Gastrin concentrations in preterm and term infants varied directly with gestational age ( p < 0.005); P W varied inversely with gestational age ( p < 0.005). In a secondary study, intestinal manometry was recorded and serial peptide concentrations were determined in 43 preterm babies who were given their first enteral feeding intraduodenally with formula or sterile water. Although none of the four peptide plasma concentrations changed in response to feeding with water, plasma concentrations of gastric inhibitory peptide, neurotensin, and P W significantly increased with formula feedings ( p < 0.05 or less).In addition, plasma gastrin increased significantly in seven infants fed milk compared with eight fed water by orogastric tube ( p < 0.01). In contrast to the peptide response to feeding, motor activity changed in response to feeding with either water or milk; motility indices increased and periods of motor quiescence decreased significantly during feeding as compared with fasting ( p < 0.02). Responses of both motor activity and peptides to feeding were time related. Although fasting concentrations of four regulatory peptides were immature in preterm infants compared with adults, postprandial responses to nutrient feedings were present in the first days of life. This discrepancy in functional maturation of the preterm intestine during fasting and feeding is present for both motor activity and peptide response, and we speculate that the controlling mechanisms of these two phases of digestion may mature independently a t different postconceptual ages. (Pediatr Res 31: 587-590,1992) Abbreviations GIP, gastric inhibitory peptide NT, neurotensin

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Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells

Cited by 44 publications

References 39 publications

Immuno-electron Microscopic Demonstration of Luminal Release of Serotonin from Enterochromaffin Cells of Rat Embryo.

Immuno-electron Microscopic Demonstration of Luminal Release of Serotonin from Enterochromaffin Cells of Rat Embryo.

A stereologic evaluation of glucagon-like peptide-1 (GLP-1) mucosal cells in the small intestine of the developing pig

Responses of Gastrointestinal Peptides and Motor Activity to Milk and Water Feedings in Preterm and Term Infants

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