Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish

Dumitrescu, Eduard; Karunaratne, Dinusha P.; Prochaska, Morgan; Liu, Xiaobo; Wallace, Karen; Andreescu, Silvana

doi:10.1016/j.envpol.2017.06.016

Cited by 31 publications

(10 citation statements)

References 51 publications

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“…Glycine is a neurotransmitter that has been shown to be vital to neuronal migration, MAPK signaling, and mitochondrial function in the brain [ 89 , 90 , 91 ]. In zebrafish, glycine-treated animals exhibited developmental defects in the heart, liver, and brain [ 92 ]. Another study determined that glycine treatment had dose-dependent biphasic effects on vasculature development in zebrafish [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

2022

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The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane that is responsible for regulating glycine levels and contributing one-carbon units to folate metabolism. Congenital mutations in GCS components, such as glycine decarboxylase (gldc), cause an elevation in glycine levels and the rare disease, nonketotic hyperglycinemia (NKH). NKH patients suffer from pleiotropic symptoms including seizures, lethargy, mental retardation, and early death. Therefore, it is imperative to fully elucidate the pathological effects of gldc dysfunction and glycine accumulation during development. Here, we describe a zebrafish model of gldc deficiency that recapitulates phenotypes seen in humans and mice. gldc deficient embryos displayed impaired fluid homeostasis suggesting renal abnormalities, as well as aberrant craniofacial morphology and neural development defects. Whole mount in situ hybridization (WISH) revealed that gldc transcripts were highly expressed in the embryonic kidney, as seen in mouse and human repository data, and that formation of several nephron segments was disrupted in gldc deficient embryos, including proximal and distal tubule populations. These kidney defects were caused by alterations in renal progenitor populations, revealing that the proper function of Gldc is essential for the patterning of this organ. Additionally, further analysis of the urogenital tract revealed altered collecting duct and cloaca morphology in gldc deficient embryos. Finally, to gain insight into the molecular mechanisms underlying these disruptions, we examined the effects of exogenous glycine treatment and observed analogous renal and cloacal defects. Taken together, these studies indicate for the first time that gldc function serves an essential role in regulating renal progenitor development by modulating glycine levels.

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Section: Discussionmentioning

confidence: 99%

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

2022

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“…Preparation of H 2 N-SiO 2 core particles A slightly modified sol-gel method was used for the preparation of H 2 N-SiO 2 core particles. 50,82 Briefly, 25 wt% CTAB (14.1817 g) solution was taken in a three necked round bottom flask with concomitant addition of H 2 O (87.0 g), ethanol (24.50 g) and DEA (0.2727 g). The reaction mixture was placed in a thermostat hot water bath maintained at 60 1C.…”

Section: Methodsmentioning

confidence: 99%

Impact of mesoporous SiO₂ support for Ni/polypyrrole nanocomposite particles on their capacitive performance

et al. 2022

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“…H 2 N‐SiO 2 seed particles were prepared by a slightly modified sol–gel method 36,65,66 . Amounts of 14.20 g of DD water solution containing CTAB (25%), 0.2745 g of DEA and 27% (v/v) aqueous ethanol (112.0 mL) were taken in a three‐necked round flask.…”

Section: Methodsmentioning

confidence: 99%

“…Preparation of mesoporous H 2 N-SiO 2 seed particles H 2 N-SiO 2 seed particles were prepared by a slightly modified sol-gel method. 36,65,66 Amounts of 14.20 g of DD water solution containing CTAB (25%), 0.2745 g of DEA and 27% (v/v) aqueous ethanol (112.0 mL) were taken in a three-necked round flask. The mixture was magnetically stirred at 250 rpm for 30 min under a nitrogen atmosphere while immersed in a thermostat water bath at 60 °C.…”

Section: Experimental Materialsmentioning

confidence: 99%

Layer‐by‐layer preparation of electromagnetic NH₂‐SiO₂/polypyrrole/Ni nanocomposites, characterization and their electrochemical properties

Ali

Rahman

Minami

et al. 2022

Polymer International

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Combinations of organic conducting polymers and inorganic electromagnetic materials have drawn much attention in various fields like energy storage materials, biosensors, biomedical applications, catalysis and removal of heavy metals from water. In this investigation an attempt is made to decorate polypyrrole (PPy), a semiconducting electroactive polymer, with Ni nanoparticles on a functional silica (SiO 2 ) support. First, amine-functionalized mesoporous NH 2 -SiO 2 seed particles are prepared by the sol-gel method using hexamethylenediamine as a surface-functionalizing agent and cetyltrimethylammonium bromide as a template. Second, NH 2 -SiO 2 /PPy composite particles are prepared via in situ seeded chemical oxidative polymerization of pyrrole. The surface of the NH 2 -SiO 2 /PPy composite particles is finally immobilized/doped with Ni nanoparticles via in situ chemical reduction of Ni(II) salt. The surface morphology, structure modification, size distribution and magnetic properties of the prepared NH 2 -SiO 2 /PPy/Ni nanocomposite particles are confirmed using various spectroscopic techniques, electron microscopy, Brunauer-Emmett-Teller measurements, X-ray diffraction and vibrating sample magnetometry. The NH 2 -SiO 2 /PPy/Ni nanocomposite particles possess good paramagnetic properties. A comparative study of electrochemical properties revealed improvement in specific capacitance of NH 2 -SiO 2 /PPy composite compared to PPy but further decoration with Ni nanoparticles under alkaline condition reduces the capacitance value.

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Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish

Cited by 31 publications

References 51 publications

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

Impact of mesoporous SiO₂ support for Ni/polypyrrole nanocomposite particles on their capacitive performance

Layer‐by‐layer preparation of electromagnetic NH₂‐SiO₂/polypyrrole/Ni nanocomposites, characterization and their electrochemical properties

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Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish

Cited by 31 publications

References 51 publications

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

Impact of mesoporous SiO2 support for Ni/polypyrrole nanocomposite particles on their capacitive performance

Layer‐by‐layer preparation of electromagnetic NH2‐SiO2/polypyrrole/Ni nanocomposites, characterization and their electrochemical properties

Contact Info

Product

Resources

About

Impact of mesoporous SiO₂ support for Ni/polypyrrole nanocomposite particles on their capacitive performance

Layer‐by‐layer preparation of electromagnetic NH₂‐SiO₂/polypyrrole/Ni nanocomposites, characterization and their electrochemical properties