In this research, it was aimed to examine the relationship between epistemological beliefs toward learning and self-efficacy of prospective teachers studying in the physical education and sports teaching department. In the research, 1135 prospective physical education and sports teachers from seven different universities in seven geographical regions were reached. The epistemological beliefs toward learning and the teacher self-efficacy scale were used to determine the opinions of the participant group. The analyzes of the data obtained from the scale forms were evaluated using the licensed SPSS 22.0 package program. In the epistemological belief scale of the research, significant differences were determined in the gender and class variables of the prospective teachers. In the teacher self-efficacy scale, significant differences were found in the class variable, but no significant difference was found in the gender variable. Based on the results of this research, the epistemological beliefs of prospective physical education and sports teachers toward learning and teacher self-efficacy beliefs are moderate, and the relationship between them is positive and weak. Finally, the curricula should be altered to accommodate prospective teachers' learning by doing in order to develop their general competencies in teaching. The curriculum should include activities that will improve the scientific thinking skills of teacher candidates.