Dexamethasone Alters TNF-α Expression in Retinopathy

Induction of IL-8, MCP-1, and bFGF by TNF-α in retinal glial cells: implications for retinal neovascularization during post-ischemic inflammation

“…It has been reported that the mRNA level of TNF-a is elevated in a mouse model of ischemia-induced retinal neovascularization [10,22]. In this study, we demonstrated that TNF-a is expressed in the macrophages/microglia in the same mouse model which suggested that the increased expression of TNF-a might be partly due to the enhanced expression of TNF-a by macrophages/microglia.…”

Association of antenatal steroid and risk of retinopathy of prematurity: a systematic review and meta-analysis

“…First, steroids could reduce the expression of tumour necrosis factor alpha, which has an angiogenic and inflammatory role in the pathogenesis of proliferative retinopathy, and hence reducing ROP development 49. Second, steroids may reduce the oxidative stress 50.…”

Neurodevelopmental Outcomes of Extremely Low Birth Weight Infants Exposed Prenatally to Dexamethasone Versus Betamethasone

“…Previous studies suggested that prenatal steroid exposure may decrease the risk of ROP, [25][26][27][28][29] possibly because of glucocorticoidmediated acceleration of retinal vascular maturation and inhibition of tumor necrosis factor-␣ production, a key factor in inflammatory and angiogenic mechanisms. 29 In our previous neonatal outcome study of this cohort, there were no statistical differences in the risks of ROP or severe ROP associated with either dexamethasone or betamethasone, compared with no prenatal steroid exposure or with each other. The current study had a very low rate of blindness, however, and the possibility of a type II error cannot be ruled out.…”