Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm Infants

Yazdi, S. M. Zaki R.; Patel, Ekta; Richardson, Colby D; Hardy, Karen; Baatz, John E.; Mulligan, Jennifer K.; Ryan, Rita M.

doi:10.3390/children8100879

Cited by 2 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, one of the strengths of the study is the validation of the results in a second, independent cohort and employing a different analysis kit. Although some studies have found differences in cytokine concentrations in TA following administration of systemic corticosteroids in preterm infants, in our case, none of our patients had received systemic steroids prior to sample collection; 39 hence, this factor does not affect our results. CONCLUSIONS TNF-α in BALF and GSA in BALF and TA have shown to be associated with VAP in preterm newborns, thus they could be used as early biomarkers of VAP.…”

Section: Discussionmentioning

confidence: 72%

Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants

et al. 2022

View full text Add to dashboard Cite

Introduction Ventilator-associated pneumonia (VAP) constitutes a serious nosocomial infection. Our aim was to evaluate the reliability of cytokines and oxidative stress/inflammation biomarkers in bronchoalveolar lavage fluid (BALF) and tracheal aspirates (TA) as early biomarkers of VAP in preterm infants. Methods Two cohorts were enrolled, one to select candidates and the other for validation. In both, we included preterms with suspected VAP, according to BALF culture, they were classified into confirmed VAP and no VAP. Concentration of 16 cytokines and 8 oxidative stress/inflammation biomarkers in BALF and TA was determined in all patients. Results In the first batch, IL-17A and TNF-α in BALF, and in the second one IL-10, IL-6, and TNF-α in BALF were significantly higher in VAP patients. BALF TNF-α AUC in both cohorts was 0.86 (sensitivity 0.83, specificity 0.88). No cytokine was shown to be predictive of VAP in TA. A statistically significant increase in the VAP group was found for glutathione sulfonamide (GSA) in BALF and TA. Conclusions TNF-α in BALF and GSA in BALF and TA were associated with VAP in preterm newborns; thus, they could be used as early biomarkers of VAP. Further studies with an increased number of patients are needed to confirm these results. Impact We found that TNF-α BALF and GSA in both BALF and TA are capable of discriminating preterm infants with VAP from those with pulmonary pathology without infection. This is the first study in preterm infants aiming to evaluate the reliability of cytokines and oxidative stress/inflammation biomarkers in BALF and TA as early diagnostic markers of VAP. We have validated these results in two independent cohorts of patients. Previously studies have focused on full-term neonates and toddlers and determined biomarkers mostly in TA, but none was exclusively conducted in preterm infants.

show abstract

Section: Discussionmentioning

confidence: 72%

Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although endotracheal intubation for mechanical ventilation is intrusive, tracheal suctioning is administered as required to preserve airway patency in intubated newborns, and it is relatively noninvasive. The convenience of sample acquisition via routine endotracheal suctioning is one of the key benefits of TA examination, even though that leads to a lack of sampling of initially non-intubated infants who may subsequently develop BPD and may not necessarily represent the distal lung parenchymal milieu [ 70 ] ( supplementary table S1 ).…”

Section: Biofluid Biomarkersmentioning

confidence: 99%

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?

Cui

2023

ERJ Open Res

View full text Add to dashboard Cite

Despite remarkable breakthroughs in diagnosis and treatment, the prevalence of bronchopulmonary dysplasia (BPD) in preterm infants and the consequent mortality have remained high over the last half-century. The pathophysiology of BPD is complicated, with several causes. In addition, infants with severe BPD are predisposed to a variety of complications that need multidisciplinary collaboration during hospitalisation and post-discharge home treatment. Consequently, early prediction, precise prevention, and individualised management have become the cornerstones of therapeutic care of preterm infants with BPD, thereby improving patient survival and prognosis. BPD has an operational clinical description; however, it has various clinical phenotypes and endotypes, making accurate prediction challenging. Currently, most approaches for predicting BPD in preterm infants include invasive collection of biofluids, which is inappropriate in fragile neonates. Consequently, researchers and clinicians are becoming more interested in noninvasive monitoring for BPD prediction. Comprehensive assessments of pertinent research, however, remain scarce. In this review, we compared many noninvasive monitoring techniques that contribute to early prediction of BPD development in premature infants.

show abstract

Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm Infants

Cited by 2 publications

References 32 publications

Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants

Early molecular markers of ventilator-associated pneumonia in bronchoalveolar lavage in preterm infants

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?

Contact Info

Product

Resources

About