Dexamethasone as an anti-cancer or hepatotoxic

Motafeghi, Farzaneh; Mortazavi, Parham; Ghassemi-Barghi, Nasrin; Zahedi, Mohammad Javad; Shokrzadeh, Mohammad

doi:10.1080/15376516.2022.2105183

Cited by 18 publications

(6 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 shows the toxicity test of the compounds. As the figures depict, the synthesized compounds are non-toxic and allow cell growth [22,23]. The results of MTT method cell viability indicate the biocompatibility of nano composite scaffolds.…”

Section: Resultsmentioning

confidence: 93%

Cytotoxicity Study of nHAP/Chitosan and nHAP/Cellulose Composite Scaffolds Synthesized via Co-Precipitation for Bone Tissue Engineering

Shokrzadeh

Motafeghi

Farhadyar

et al. 2023

JBBBE

Self Cite

View full text Add to dashboard Cite

The main purpose of this study is to synthesize nano-hydroxyapatite/cellulose (nHAP/Cel) and nano-hydroxyapatite/chitosan (nHAP/CS) scaffolds via co-precipitation method for bone tissue engineering due to their suitable biocompatibility, cytotoxicity and mechanical properties. The characterizations of these scaffolds were investigated by Infrared absorption spectra (FT-IR), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The cytotoxicity of these nanoparticles was evaluated with bone marrow cell using the 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazoliumbromide) (MTT) assay. The porosity of scaffolds was estimated 87%. The results indicate that the nano composite scaffolds have good morphology, tissue biocompatibility and biodegradability to be used for tissue engineering.

show abstract

Section: Resultsmentioning

confidence: 93%

Cytotoxicity Study of nHAP/Chitosan and nHAP/Cellulose Composite Scaffolds Synthesized via Co-Precipitation for Bone Tissue Engineering

Shokrzadeh

Motafeghi

Farhadyar

et al. 2023

JBBBE

Self Cite

View full text Add to dashboard Cite

show abstract

“…Acetaminophen induced hepatotoxicity (AIH) is mainly caused by the toxic metabolite N-acetyl benzoquinone imine (NAPQI) [ 23 ]. Inflammation and oxidative stress play important roles in liver injury, dexamethasone induces oxidative stress and activation of caspase-3, leading to liver toxicity [ 24 ]. A study evaluating the relationship between atorvastatin and liver toxicity in a real-world environment showed that the risk of liver toxicity increased by 1.3–1.5 times after taking atorvastatin [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Post-marketing safety concerns of sotorasib: A disproportionality analysis based on FDA adverse event reporting system

Ding,

Su,

Shu

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…The non-healing phenotype because systemic effects of DFU is neuropathy, impaired immune system components and peripheral vascular disease, a condition that inhibits proper wound healing in diabetes with hyperglycemic circumstance [20,21]. For wounds that stall to eliminate after 4 weeks of standard care, reconsideration of the underlying pathology and assessment of the demand for progressive therapeutic agents should be assumed [22,23].…”

Section: Introductionmentioning

confidence: 99%

An in vivo investigation on the wound-healing activity of Specific ligand for the innate repair receptor, ARA290, using a diabetic animal model

Mashreghi¹,

Bayrami

Sichani

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

The diabetic foot ulcer (DFU) are serious problems to diabetes and may be associated with late healing and septic manifestation, consequently result in amputation which is an extortionate incident. The innate repair receptor (IRR) is expressed by injured tissues and is activated by erythropoietin produced and released into damaged tissue. Activation of the IRR might provide benefit for diabetic wound healing. This study evaluated effect of a specific IRR agonist, ARA290, on skin wound repair. The aim of the present study was to evaluate the effect of topical application based on ARA290, in streptozotocin-induced diabetic incision wound models rats. The treatment was performed daily, until day 14 after wound induction. Wound closure was determined and the features of the repaired tissue were examined, including amount of collagen and protein content, biochemical parameters, antioxidant status and proinflammatory cytokines. The data confirmed wound healing activities via macroscopic, biochemical, immunofluorescent and molecular methods. There was meaningful acceleration in wound closure rate, decrease in the period of re-epitalization, greater amount of collagen and protein content in ARA290 treated group when compared with control group. The increase of serum insulin and HDL was divergent with blood glucose decrease and reduced lipid level. The healing effect was confirmed by reduced levels of inflammatory cytokines and lipid peroxidation and augmented antioxidants. The results propose that ARA290-arbitrated IRR activation may signify an appealing approach to treat diabetes-associated wound healing.

show abstract

Dexamethasone as an anti-cancer or hepatotoxic

Cited by 18 publications

References 53 publications

Cytotoxicity Study of nHAP/Chitosan and nHAP/Cellulose Composite Scaffolds Synthesized via Co-Precipitation for Bone Tissue Engineering

Cytotoxicity Study of nHAP/Chitosan and nHAP/Cellulose Composite Scaffolds Synthesized via Co-Precipitation for Bone Tissue Engineering

Post-marketing safety concerns of sotorasib: A disproportionality analysis based on FDA adverse event reporting system

An in vivo investigation on the wound-healing activity of Specific ligand for the innate repair receptor, ARA290, using a diabetic animal model

Contact Info

Product

Resources

About