Dexamethasone plus glucagon‐like peptide 2 given to lactating rat dams has a late effect on intestinal lipid uptake in the weanling offspring

Iordache, Claudiu; Drozdowski, Laurie; Clandinin, Tom; Wild, Gary; Todd, Zoe; Thomson, A. B. R.

doi:10.1177/0148607104028005355

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…In contrast, DEX reduced the ileal lipid uptake in suckling and weanling rats (Tables 3, 4). This effect likely occured during pregnancy, since DEX given during lactation enhanced lipid uptake in the offspring (32). The decline in lipid uptake with DEX was also associated with an increase in the jejunal mucosal mass in sucklings (Table 1), although changes in the jejunal villous morphology were found only in weanlings (data not shown).…”

Section: Discussionmentioning

confidence: 92%

Lipid malabsorption persists after weaning in rats whose dams were given GLP‐2 and dexamethasone

Iordache

Drozdowski

Clandinin

et al. 2005

Lipids

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Glucagon-like peptide-2 (GLP-2) enhances intestinal growth and absorption in mature animals, and glucocorticosteroids (GC) increase the sugar and lipid uptake in adult animals. However, the role of GC and GLP-2 in the ontogeny of lipid absorption is unknown. We hypothesized that GLP-2 and the GC dexamethasone (DEX), when administrated to rat dams during pregnancy and lactation, would enhance lipid uptake in the offspring. Rat dams were treated in the last 10 d of pregnancy and during lactation with GLP-2 [0.1 microg/g/d subcutaneous (sc)], DEX (0.128 microg/g/d sc), GLP-2 + DEX, or a placebo. Sucklings were sacrificed at 19-21 d of age, and weanlings were sacrificed 4 wk later. Lipid uptake was assessed using an in vitro ring uptake method. Although DEX and GLP-2 + DEX increased the jejunal mass, the jejunal lipid uptake was unchanged. In contrast, GLP-2, DEX, and GLP-2 + DEX reduced the ileal lipid uptake in suckling and weanling rats. This reduction was not due to alterations in intestinal morphology or to changes in fatty acid-binding protein abundance, but it was partially explained by an increase in the effective resistance of the intestinal unstirred water layer. In sucklings, DEX dramatically reduced the jejunal lipid uptake to levels similar to those seen in weanlings, such that the normal ontogenic decline in lipid uptake was not observed. Giving dams GLP-2 or DEX during pregnancy and lactation reduced lipid uptake in the offspring, and this persisted for at least 1 mon. The impact this may have on the nutritional well-being of the animal in later life is unknown.

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Section: Discussionmentioning

confidence: 92%

Lipid malabsorption persists after weaning in rats whose dams were given GLP‐2 and dexamethasone

Iordache

Drozdowski

Clandinin

et al. 2005

Lipids

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“…In adult animals, glucagon-like peptide (GLP)-2 has a trophic effect on the intestine, and enhances nutrient absorption. In contrast, in young animals, there is malabsorption of several lipids with GLP-2 or GLP-2 plus dexamethasone, but not with dexamethasone itself [18] . The loss of body weight and jejunal atrophy induced by dexamethasone is prevented by giving GLP-2.…”

Section: Intestinal Developmentmentioning

confidence: 86%

Recent advances in small bowel diseases: Part I

Thomson¹

2012

WJG

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As is the case in all parts of gastroenterology and hepatology, there have been many advances in our knowledge and understanding of small intestinal diseases. Over 1000 publications were reviewed for 2008 and 2009, and the important advances in basic science as well as clinical applications were considered. In Part I of this Editorial Review, seven topics are considered: intestinal development; proliferation and repair; intestinal permeability; microbiotica, infectious diarrhea and probiotics; diarrhea; salt and water absorption; necrotizing enterocolitis; and immunology/allergy. These topics were chosen because of their importance to the practicing physician.

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Prenatal dexamethasone exposure, postnatal development, and adulthood prepulse inhibition and latent inhibition in Wistar rats

Hauser

Feldon

Pryce

2006

Behavioural Brain Research

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Dexamethasone plus glucagon‐like peptide 2 given to lactating rat dams has a late effect on intestinal lipid uptake in the weanling offspring

Cited by 6 publications

References 38 publications

Lipid malabsorption persists after weaning in rats whose dams were given GLP‐2 and dexamethasone

Lipid malabsorption persists after weaning in rats whose dams were given GLP‐2 and dexamethasone

Recent advances in small bowel diseases: Part I

Prenatal dexamethasone exposure, postnatal development, and adulthood prepulse inhibition and latent inhibition in Wistar rats

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