2016
DOI: 10.2527/jas.2016-0572
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Dexamethasone treatment differentially alters viral shedding and the antibody and acute phase protein response after multivalent respiratory vaccination in beef steers123

Abstract: Our objective was to examine immunosuppression induced by dexamethasone (DEX) administration in cattle on immunological responses to a multivalent respiratory vaccine containing replicating and nonreplicating agents. Steers ( = 32; 209 ± 8 kg) seronegative to infectious bovine rhinotracheitis virus (IBRV), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), and parainfluenza-3 virus (PI3V) were stratified by BW and randomly assigned to 1 of 3 treatments: 1) acute immunosuppression (A… Show more

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Cited by 15 publications
(17 citation statements)
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“…Cattle treated with an "acute," "chronic," or "control" stress model, induced by dexamethasone treatment and vaccinated with a multivalent combination respiratory vaccinebacterin, generated different antibody titer responses depending on the antigenspecific antibody evaluated. 33 The leukotoxin-specific antibody response from a M haemolytica toxoid was least in the chronic dexamethasone-challenged steers, intermediate for acute, and greatest for control steers. 33 Conversely, both the BHV-1-and BVDV-specific antibody response from the MLV fraction of the combination vaccine was greatest for chronic dexamethasone-challenged steers, intermediate for acute, and least for control steers.…”
Section: Stress and Vaccine Efficiencymentioning
confidence: 94%
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“…Cattle treated with an "acute," "chronic," or "control" stress model, induced by dexamethasone treatment and vaccinated with a multivalent combination respiratory vaccinebacterin, generated different antibody titer responses depending on the antigenspecific antibody evaluated. 33 The leukotoxin-specific antibody response from a M haemolytica toxoid was least in the chronic dexamethasone-challenged steers, intermediate for acute, and greatest for control steers. 33 Conversely, both the BHV-1-and BVDV-specific antibody response from the MLV fraction of the combination vaccine was greatest for chronic dexamethasone-challenged steers, intermediate for acute, and least for control steers.…”
Section: Stress and Vaccine Efficiencymentioning
confidence: 94%
“…33 The leukotoxin-specific antibody response from a M haemolytica toxoid was least in the chronic dexamethasone-challenged steers, intermediate for acute, and greatest for control steers. 33 Conversely, both the BHV-1-and BVDV-specific antibody response from the MLV fraction of the combination vaccine was greatest for chronic dexamethasone-challenged steers, intermediate for acute, and least for control steers. 33 The greater antibody titer for dexamethasone-treated cattle administered MLV is probably a result of much greater replication of the liveattenuated vaccine agents in the immunosuppressed host.…”
Section: Stress and Vaccine Efficiencymentioning
confidence: 94%
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“…Unfortunately, stocker calves experience numerous stressors that could affect the efficacy of vaccination and it has been established that stress can suppress immune function in cattle (Carrasco and Van de Kar, 2003;Charmandari et al, 2005). In addition, stress can also contribute to increased shedding of viral respiratory pathogens (Fulton et al, 2016;Richeson et al, 2016). However, more recent work uses dexamethasone to simulate stress-induced immunosuppression in otherwise healthy cattle with a known health and transportation history (Richeson et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, stress can also contribute to increased shedding of viral respiratory pathogens (Fulton et al, 2016;Richeson et al, 2016). However, more recent work uses dexamethasone to simulate stress-induced immunosuppression in otherwise healthy cattle with a known health and transportation history (Richeson et al, 2016). Therefore, the objectives of this study were to characterize the cell-mediated immune responses of multiple source, highly commingled calves of unknown health history and compare the responses of these calves to a group of calves that were single source, of a known health history, and weaned for 60 d.…”
Section: Introductionmentioning
confidence: 99%