Dexketoprofen-induced antinociception in animal models of acute pain: Synergy with morphine and paracetamol

Miranda, Hugo F.; Puig, Margarita M.; Dürsteler, C.; Prieto, Juan Carlos; Pinardi, G.

doi:10.1016/j.neuropharm.2006.07.025

Cited by 46 publications

(49 citation statements)

References 30 publications

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“…The method of isobolographic analysis has been described previously in detail [11,12]. The isobologram was built by connecting the ED 50 of the codeine plotted on the abscissa with the ED 50 of the morphine plotted on the ordinate to obtain the additivity line.…”

Section: Isobolographic Analysismentioning

confidence: 99%

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Systemic synergism between codeine and morphine in three pain models in mice

Miranda

Noriega

Zepeda

et al. 2013

Pharmacological Reports

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Abstract:Background: The combination of two analgesic agents offers advantages in pain treatment. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. Methods: This study, performed in mice using isobolographic analysis, evaluated the type of interaction in intraperitoneal (ip) or intrathecal (it) coadministration of codeine and morphine, in three nociceptive behavioral models. Results: Intrathecal morphine resulted to be 7.5 times more potent than ip morphine in the writhing test, 55.6 times in the tail flick test and 1.7 times in phase II of the orofacial formalin test; however, in phase I of the same test ip was 1.2 times more potent than it morphine. Intrathecal codeine resulted being 3.4 times more potent than ip codeine in the writhing test, 1.6 times in the tail flick test, 2.5 times in phase I and 6.7 times in phase II of the orofacial formalin test. Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test). The interaction index ranged between 0.284 (writhing ip) and 0.440 (orofacial formalin phase II ip). Conclusion: This synergy may relate to the different pathways of pain transmission and to the different intracellular signal transduction. The present findings also raise the possibility of potential clinical advantages in combining opioids in pain management. Key words: opioids, algesiometer tests, isobolographic analysis, synergismAbbreviations: DOR -delta opioid receptor, ED # -dosage that produced 50% of MPE, I.I. -interaction index, ipintraperitoneal, it -intrathecal, KOR -k opioid receptor, MPE -maximum possible effect, MOR -µ opioid receptor, NSAIDs -nonsteroidal anti-inflammatory drugs, NOP -nociceptin opioid receptor, SEM -standard mean error

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Section: Isobolographic Analysismentioning

confidence: 99%

“…Combining different agents also enhances efficacy in complex pain conditions involving multiple causes [22]. Interactions between opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) have been previously reported [10,11].…”

Section: Introductionmentioning

confidence: 99%

Systemic synergism between codeine and morphine in three pain models in mice

Miranda

Noriega

Zepeda

et al. 2013

Pharmacological Reports

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“…The algesiometric test was similar to that described previously (Miranda et al 2007). A radiant heat, automatic tail flick algesiometer (Ugo Basile, Comerio, Italy) was used to measure response latencies.…”

Section: Tail Flick Testmentioning

confidence: 99%

“…A least-squares linear regression analysis of the log dose-response curve allowed the calculation of the doses that produced 25% of antinociception when each drug was administered alone (ED25 for tail flick and orofacial formalin tests). ED25 was used in the tail flick and orofacial formalin tests as the equieffective dose for isobolographic analysis because higher doses did not show increased effects without motor impairments (Miranda et al 2007). Then a similar dose-response curve was also obtained and analyzed after the co-administration of metamizol with paracetamol in fixed ratio (1:1) combinations based on the mixture of 1/2, 1/4, 1/8, 1/16 of their respective ED25 values.…”

Section: Protocolmentioning

confidence: 99%

Synergism between COX-3 inhibitors in two animal models of pain

et al. 2010

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These actions can be related to the differential selectivity of the drugs for inhibition of COX isoforms and also to the several additional antinociception mechanisms and pathways initiated by the analgesic drugs on pain transmission. Since the efficacy of the combination of metamizol with paracetamol has been demonstrated in the present study, this association could have a potential beneficial effect on the pharmacological treatment of clinical pain.

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“…The method described by other authors (Garcia et al, 2011;Godin et al, 2011;Miranda et al, 2007) was used. To perform the test, 20 mL of 2.5% formalin solution was injected into the right hind paw plantar surface (hypodermic injection).…”

Section: Formalin Test In the Hind Pawmentioning

confidence: 99%

Antinociceptive activity and chemical composition of Wei–Chang–An–Wan extracts

Liu

Zhang

Gao

et al. 2013

Pharmaceutical Biology

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Context: Currently, famous traditional Chinese medicine formulas have undergone re-evaluation and development in China. Wei-Chang-An-Wan (WCAW) as one of them has been used for treating various gastrointestinal diseases for several decades. The secondary development of WCAW is in progress so as to interpret the effective material basis or find new pharmacological activity. Objective: To evaluate the antinociceptive effect of methanol extract of WCAW (ME) as well as four fractions (P.E., EtOAc, n-BuOH, H 2 O) and obtain information on the correlation between the contents of the fractions and antinociceptive effect. Materials and methods: ME was divided into four parts extracted by petroleum ether, ethyl acetate and n-butanol. Antinociceptive activity was evaluated by three models of acetic acid-induced writhing, formalin and hot-plate test in mice after repetitive administration of ME at 200, 400 or 800 mg/kg, P.E. 132 mg/kg, EtOAc 106 mg/kg, n-BuOH 176 mg/kg and H 2 O 176 mg/kg for six days. The chemical compounds were analyzed by HPLC-ESI-MS. Results: ME at 800 mg/kg inhibited acid-induced writhing by 84.69%, and reduced the licking time of second phase in formalin test by 53.23%. The inhibition rates in acid-induced writhing of P.E., EtOAc, n-BuOH and H 2 O were 27.79, 33.85, 38.97 and 37.69%, respectively, and in formalin test about 50%. They had no effect on the hot-plate test. HPLC-ESI-MS analysis showed that 68 chemical compounds were detected and 41 compounds were identified from ME. Discussion and conclusion: The results obtained herein indicate that WCAW possesses the antinociceptive activity that provides a new aspect in clinical application.

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Dexketoprofen-induced antinociception in animal models of acute pain: Synergy with morphine and paracetamol

Cited by 46 publications

References 30 publications

Systemic synergism between codeine and morphine in three pain models in mice

Systemic synergism between codeine and morphine in three pain models in mice

Synergism between COX-3 inhibitors in two animal models of pain

Antinociceptive activity and chemical composition of Wei–Chang–An–Wan extracts

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