Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats via Extracellular Signal-Regulated Kinase/Cyclic Adenosine Monophosphate Response Element Binding Protein Signaling Pathway

Lu, Taihe; Chen, Weiguang; Yin, Changyou; Zhang, Hongtao; Zhao, Qian

doi:10.1016/j.wneu.2019.03.232

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…is, in the Dex group, was obviously lower than that in the Ctrl. It was consistent with previous studies of meningioma patients and patients with ischemic cerebrovascular disease [15], indicating that continuous intraoperative Dex infusion can obviously improve postoperative cognitive function and reduce the incidence of postoperative POCD. S100β protein is mainly distributed in the central nervous system and is a kind of acidic calcium binding protein, mainly synthesized and secreted by astrocytes.…”

Section: Discussionsupporting

confidence: 92%

Curve Fitting Algorithm-Based Contrast-Enhanced Ultrasound Image for Evaluating the Effect of Dexmedetomidine on Neurological Function in Patients Undergoing Brain Tumor Surgery

Sun

et al. 2022

Scientific Programming

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Objective. The study aimed to explore the influence of dexmedetomidine (Dex) guided by ultrasonic contrast on postoperative cognitive function, serum nerve injury factors, inflammatory response, and blood glucose in patients undergoing intracerebral tumor resection through curve fitting algorithm. Methods. 80 patients who underwent tumor resection were selected and randomly rolled into control (Ctrl) group and Dex group, with 40 in each. Then, patients in the Dex group received 0.4 μg/kg⋅h Dex, and patients in Ctrl received the same amount of normal saline. Both groups were diagnosed with benign or malignant tumors by contrast-enhanced ultrasound (CEUS) based on time-intensity curve (TIC) before surgery. Cognitive Capacity Screening Examination (CCSE) and Montreal Cognitive Assessment (MoCA) were used to assess the cognitive function 1 day before and 3 days after the operation, and the ELISA method was used to detect levels of nerve damage-related factors and inflammation factor. Finally, the fasting blood glucose (FBG) levels were detected at the same time. Results. In contrast with benign lesions, the AUC, MTT, and PI of malignant lesions were obviously reduced ( P < 0.05 ), while TP was obviously increased ( P < 0.05 ). The postoperative CCSE and MoCA scores of the Dex group were obviously higher than Ctrl ( P < 0.05 ). In contrast with the Ctrl, the CCSE and MoCA scores in the Dex group increased obviously after 3 days ( P < 0.05 ). In addition, the incidence of postoperative cognitive dysfunction (POCD) in the Dex group was obviously reduced ( P < 0.05 ). Besides, levels of S100β, NSE, and GFAP were obviously reduced in the Dex group 1 day after surgery ( P < 0.05 ), while levels of IL-6 and TNF-α were obviously reduced ( P < 0.05 ), and returned to the level of Ctrl 3 days after surgery. There was no obvious difference in FBG at each time point between the two. Conclusion. CEUS based on curve fitting algorithm is effective on nursing treatment of intracranial tumors. Dex can obviously improve POCD and reduce levels of serum nerve injury factors and inflammatory factors.

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Section: Discussionsupporting

confidence: 92%

Curve Fitting Algorithm-Based Contrast-Enhanced Ultrasound Image for Evaluating the Effect of Dexmedetomidine on Neurological Function in Patients Undergoing Brain Tumor Surgery

Sun

et al. 2022

Scientific Programming

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“…Furthermore, Akt activates cAMP response element-binding protein (CREB) by phosphorylation (pSer 133 CREB), which is known to enhance cardioprotection against ischemia in the heart, (Marais et al, 2008) and in neural cells against cerebral ischemia reperfusion injury. (Teng et al, 2019) pSer 133 CREB was significantly reduced by hypoxia; shRNA-DISC1 reduced the low pSer 133 CREB levels further, whereas pSer 133 CREB was significantly increased by overexpression of DISC1 (Fig. 4I-J).…”

Section: Reduced Disc1 Deteriorates Cardioprotective Reperfusion Inju...mentioning

confidence: 88%

“…We also found evidence that knockdown of DISC1 inactivates mTORC2 activity, which has been shown to be necessary for full activation of Akt and cardioprotection (Yano et al, 2014). DISC1 knockdown also hinders the activation of CREB, which has previously been shown to enhance cardioprotection against ischemia (Marais et al, 2008), and to facilitate the protection of neural cells against cerebral ischemia reperfusion injury (Teng et al, 2019). The present data further show that knockdown of DISC1 significantly influences the translocation of STAT3 to the mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Loss of the protein disrupted in schizophrenia 1 (DISC1) impairs cardiac resistance against ischemia

Marwarha

Pinho

Scrimgeour

et al. 2022

Preprint

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Treatable targets that hinder heart failure development following myocardial infarction remain limited. Through an unbiased transcriptional regulation study for ischemic heart disease, we identified the protein disrupted in schizophrenia 1 (DISC1), which has been almost solely characterized in the brain. Here, we show that loss of DISC1 is a major driver of heart disease and ischemic damage. Silencing of DISC1 sensitizes human cardiomyocyte cell lines to hypoxia, whereas DISC1 overexpression is cardioprotective. Mechanistically, we provide evidence that reduced DISC1 protein levels interrupt multiple signaling processes vital for cardiomyocyte survival whereas overexpression of DISC1 enhances pro survival signalling. The present study has implications for understanding scenarios where cardiomyocytes are unable to increase the levels of DISC1 during ischemia, e.g., in individuals with DISC1 genetic defects. Indeed, patients with severe mental illness display 20 years earlier mortality, with IHD as the greatest cause of death. The present study can thus shed light on this long-term enigma in epidemiology.

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“…Cerebral ischemia is a common cause of death worldwide, after cardiovascular diseases and cancer, and its prevalence increases with increasing age (Teng et al, 2019). After the onset of brain ischemia, a series of events lead ultimately to the death of neurons (Sutherland et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Cryptotanshinone protects hippocampal neurons against oxygen-glucose deprivation-induced injury through the activation of Nrf2/HO-1 signaling pathway

Gui²,

Zhao

et al. 2022

Food Sci. Technol

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Cryptotanshinone (CPT), a terpenoid isolated from the roots of Salvia miltiorrhiza Bunge, was reported to have neuroprotective effects against cerebral ischemic stroke. However, the exact molecular mechanism underlying its neuroprotective ability remains unclear. The present study aimed to explore the regulatory effects of CPT on oxygen-glucose deprivation/reoxygenation (OGD/R)-induced cell injury in a model of hippocampal neurons. Our results demonstrated that CPT improved cell viability and reduced the lactate dehydrogenase leakage in OGD/R-stimulated hippocampal neurons. In addition, CPT significantly inhibited oxidative stress and apoptosis in hippocampal neurons after OGD/R stimulation. Furthermore, CPT significantly enhanced the nuclear translocation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression in hippocampal neurons exposed to OGD/R. Moreover, Nrf2 knockdown reversed the anti-apoptotic and anti-oxidant activities of CPT in primary hippocampal neurons exposed to OGD/R. In conclusion, these findings demonstrated that CPT attenuated oxidative stress and neuronal apoptosis after OGD/R injury through the activation of Nrf2/HO-1 signaling pathway in hippocampal neurons. Thus, CPT may be a novel therapeutic agent for cerebral I/R injury.

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Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats via Extracellular Signal-Regulated Kinase/Cyclic Adenosine Monophosphate Response Element Binding Protein Signaling Pathway

Cited by 12 publications

References 33 publications

Curve Fitting Algorithm-Based Contrast-Enhanced Ultrasound Image for Evaluating the Effect of Dexmedetomidine on Neurological Function in Patients Undergoing Brain Tumor Surgery

Curve Fitting Algorithm-Based Contrast-Enhanced Ultrasound Image for Evaluating the Effect of Dexmedetomidine on Neurological Function in Patients Undergoing Brain Tumor Surgery

Loss of the protein disrupted in schizophrenia 1 (DISC1) impairs cardiac resistance against ischemia

Cryptotanshinone protects hippocampal neurons against oxygen-glucose deprivation-induced injury through the activation of Nrf2/HO-1 signaling pathway

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