Dexmedetomidine versus Fentanyl in Attenuation of Haemodynamic Response during Laryngoscopy and IntubationA Randomised Controlled Trial

Garg, Sahil; Bhat, Anusha Ganapati; Rani, Achla

doi:10.7860/jcdr/2020/43022.13657

Cited by 2 publications

(7 citation statements)

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“…Only one study compared fentanyl, dexmedetomidine, and lidocaine [11]. All other studies have compared only fentanyl and dexmedetomidine [12][13][14][15][16][17][18]. In this meta-analysis, lidocaine was ignored, as the aim of this meta-analysis was to compare fentanyl and dexmedetomidine.…”

Section: Resultsmentioning

confidence: 99%

“…neurosurgical procedure [12], and cardiac surgery [18]. All other studies included all kinds of elective surgical procedures [13][14][15][16][17]. Two reviewers assessed the risk of bias and it was found to be perfectly consistent, which showed that the overall quality of the study was moderate.…”

Section: Resultsmentioning

confidence: 99%

“…All eight studies reported HR at baseline [11][12][13][14][15][16][17][18]. The meta-analysis results showed no significant difference in HR between the two groups at baseline (MD = 1.48; 95% CI: -0.84, 3.81; P = 0.21, I 2 = 53%), as shown in Figure 3.…”

Section: Hr At Baselinementioning

confidence: 99%

“…The meta-analysis results showed no significant difference in HR between the two groups at baseline (MD = 1.48; 95% CI: -0.84, 3.81; P = 0.21, I 2 = 53%), as shown in Figure 3. Source: [11][12][13][14][15][16][17][18].…”

Section: Hr At Baselinementioning

confidence: 99%

“…Six studies compared the HR between dexmedetomidine and fentanyl after one minute of intubation [13][14][15][16][17][18].…”

Section: Hr At One Minute After Intubationmentioning

confidence: 99%

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Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

Mohsin¹,

Ganaie²,

Kundi³

et al. 2022

Cureus

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General anesthesia induction, tracheal intubation, extubation, and laryngoscopy are associated with specific hemodynamic changes. Tracheal intubation and laryngoscopy are related to sympathetic stimulation and lead to hypertension and tachycardia. Recent studies have shown that dexmedetomidine is safe and effective as it does not depress respiratory function. This meta-analysis aims to compare the efficacy of dexmedetomidine and fentanyl in preventing an increase in heart rate (HR) during intubation among patients undergoing general anesthesia. A systematic literature search was done using PubMed, Cochrane Library, and Embase to assess studies comparing the efficacy of dexmedetomidine and fentanyl in preventing an increase in HR during intubation. A meta-analysis was done utilizing a random-effects model, and mean differences of HR were determined between fentanyl and dexmedetomidine at baseline, one minute, five minutes, and 10 minutes of intubation. In this meta-analysis, eight randomized control trials were included, involving 548 patients (274 in the fentanyl group and 274 in the dexmedetomidine group). The findings showed that significant difference of HR was significantly lower in the dexmedetomidine group than the fentanyl group at one minute of intubation (mean difference = -8.46; P-value = 0.003), at five minutes of intubation (mean difference = -7.51; P-value = 0.001), and at 10 minutes of intubation (mean difference = -5.15; P-value = 0.030). In the current meta-analysis, dexmedetomidine was better than fentanyl in preventing tachycardia following endotracheal intubation. HR was significantly lower at one minute, five minutes, and 10 minutes after intubation in the dexmedetomidine group compared to the fentanyl group.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Hr At Baselinementioning

confidence: 99%

Section: Hr At Baselinementioning

confidence: 99%

“…Six studies compared the HR between dexmedetomidine and fentanyl after one minute of intubation [13][14][15][16][17][18].…”

Section: Hr At One Minute After Intubationmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

Mohsin¹,

Ganaie²,

Kundi³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“Comparative Evaluation of Dexmedetomidine and Fentanyl to Attenuate Hemodynamic Response to Laryngoscopy and Intubation.”

Hrishikesh

Mishra

et al. 2022

ijsr

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ntroduction- Endotracheal intubation includes laryngoscopy and intubation, which often evokes cardiovascular responses characterized by increase in arterial pressure, changes in heart rate and disturbance in cardiac rhythm, which are transient variable and unpredictable.The present study was conducted and evaluated to compare the efcacy of dexmedetomidine and fentanyl in attenuating sympathoadrenal response which includes heart rate and arterial blood pressure changes during tracheal intubation. 100 adult patients of either sex belonging to ASAMethods- grade I, II, III belonging to age riagroup 18 to 80 years were posted for elective surgery under general anesthesia. . Total 100 adult patients were randomly divided into 2 groups with 50 patients in each group. Group D-Inj Dexmedetomidine 1mcg/kg 10minutes before laryngoscopy. Group F- Inj Fentanyl 2 mcg/kg 10 minutes before laryngoscopy .In predetermined time heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were observed and compared in both groups. There was rise in heart rate, systolic blood pressure, diastolic blood pressureResults- mean arterial pressure immediately after intubation, 1min.2min, 3min, 5min and 10 min after intubation Dexmedetomidine 1mcg/kgConclusion- iv produces more favourable hemodynamic response while fentanyl 2mcg/kg less effective for attenuating pressor response to laryngoscopy and endotracheal intubation.

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Dexmedetomidine versus Fentanyl in Attenuation of Haemodynamic Response during Laryngoscopy and IntubationA Randomised Controlled Trial

Cited by 2 publications

References 0 publications

Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

Comparison of Fentanyl and Dexmedetomidine in Preventing an Increase in Heart Rate During Intubation Among Patients Undergoing General Anesthesia: A Meta-Analysis

“Comparative Evaluation of Dexmedetomidine and Fentanyl to Attenuate Hemodynamic Response to Laryngoscopy and Intubation.”

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