Dexmedetomidine vs midazolam for monitored anaesthesia care during cataract surgery

Alhashemi, Jamal A.

doi:10.1093/bja/ael080

Cited by 157 publications

(163 citation statements)

References 23 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…(6) , deksmedetomidin verilen olgularda KAH' nın % 10 ve OAB'nın % 15 oranında azaldığını bildirmiştir. Alhashemi'nin (18) , MAB için deksmedetomidin ile midazolamı karşılaştırdığı katarakt ameliyatlarında, deksmedetomidin grubunda KAH ve OAB'da azalma olduğu bildirilmiştir. Çalışmamızda da, deksmedetomidin verilen grupta başlangıca göre KAH'ları, sedasyon sırasında ve postoperatif 1 ve 2. saatte istatistiksel olarak anlamlı düşük bulundu.…”

Section: Discussionunclassified

Comparison of Dexmedetomidine versus Midazolam/Remifentanil Combination for Monitorized Anaesthesia Care

Doğan¹,

Ünver²,

Tunçel³

et al. 2011

J Turk Anaesth Int Care

View full text Add to dashboard Cite

ÖZETAmaç: Monitörize anestezi bakımında deksmedetomidin ile midazolam/remifentanil kombinasyonunun nazal septum cerrahisinde karşılaştırılması amaçlandı.Gereç ve Yöntem: Lokal anestezi altında nazal septum cerrahisi planlanan 50 hasta rasgele iki gruba ayrıldı. Grup D'ye 10 dk. Sonuç: Monitorize anestezi bakımında hızlı sedasyon istendiğinde, akciğer hastalığı yoksa desaturasyon açısından uygun önlemler alınarak midazolam/remifentanil kombinasyonu; semptomatik akciğer hastalığı olanlarda maliyeti göz önünde bulundurarak ve bradikardi açısından dikkatli olunarak deksmedetomidin tercih edilebilir.Anahtar kelimeler: Monitörize anestezi bakımı, deksmedetomidin, midazolam, remifentanil SUMMARY Comparison of Dexmedetomidine versus Midazolam/Remifentanil Combination for Monitorized Anaesthesia CareObjective: The aim of this study was to compare dexmedetomidine versus midazolam/remifentanil combination for monitorized anaesthesia care during nasal septal surgery.Material and Methods: 50 patients undergoing nasal septal surgery under local anaesthesia were randomly assigned into two groups. Group D received 0,3 µg kg -1 hr -1 dexmedetomidine infusion after the loading dose of 1 µg kg -1 /10 min. Group M/R received 0,05 mg kg -1 bolus dose of midazolam over 30 seconds followed by 0,05 mg kg -1 min -1 remifentanil infusion. The infusion rates were adjusted to target level of sedation and analgesia scores. Hemodynamic and respiratory parameters, analgesia and sedation scores were recorded before (0 min.) and 1, 5 and 10 minutes after sedation, and every 5 minutes thereafter. Total amount of drugs used, patient and surgeon satisfaction scores, hemodynamic and respiratory parameters, postanaesthetic Aldrete scores, amnesia and postoperative recovery scores and side effects were recorded at 1., 5., 15., 30. minutes, and 1., 2., and 4. hours, postoperatively.Results: Sedation scores were higher in group M/R at 5 and 15 minutes, postoperatively (p<0.05). Heart rates were lower in Group D at 10 and 35 minutes (p<0.05). Respiratory rates were lower in Group M/R throughout the operation (p<0.05) and also SpO 2 values were lower at 5., 10. and 15. minutes (p<0.05). Cost of anesthesia in Group D was higher (p<0.05).Conclusion: During monitorized anaesthesia care midazolam/remifentanil can be used for rapid onset of sedation in the absence of pulmonary disease while taking measures for desaturation. Dexmedetomidine may be preferred not disregarding bradycardic complications in symptomatic pulmonary disease, and its higher cost.

show abstract

Section: Discussionunclassified

Comparison of Dexmedetomidine versus Midazolam/Remifentanil Combination for Monitorized Anaesthesia Care

Doğan¹,

Ünver²,

Tunçel³

et al. 2011

J Turk Anaesth Int Care

View full text Add to dashboard Cite

show abstract

“…Intravenous sedation with midazolam is sometimes used in MAC for day-stay surgery with regional anesthesia to relieve stress during surgery for the elderly patients [1][2][3]. However, an increased risk of falls after administration of sedatives has been reported [10].…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous sedation is sometimes used to relieve stress during surgery for the elderly patients [1][2][3]. Assessing the recovery of dynamic balance function involving movement of the center of gravity after intravenous sedation in the elderly, whose activities of daily life might be significantly decreased owing to falls or fractures, is important for ensuring safe discharge, especially by walking.…”

Section: Introductionmentioning

confidence: 99%

Correlation between precise and simple tests in recovery of dynamic balance function after intravenous sedation with midazolam in the elderly

et al. 2007

View full text Add to dashboard Cite

Purpose. Assessing the recovery of dynamic balance after intravenous sedation in the elderly is important for ensuring safe discharge, especially by walking. A reliable, simple dynamic balance test would be useful in daily clinical practice. We observed the recovery of balance after intravenous sedation with midazolam using computerized dynamic posturography (CDP) and evaluated the correlation between the CDP and simple dynamic balance tests.Methods. midazolam was administered in divided dose until the Wilson sedation score reached 3 in 18 elderly male volunteers. A dynamic balance test using CDP with perturbation stimuli was performed before and after sedation. As simple dynamic balance tests, the usual-speed walking (USW) and maximum-speed walking (MSW) tests and the modified timed "Up & Go" (TUG) test (subjects stand up from a chair, walk 5 m forward and back with MSW, and sit down again) were performed.Results. The recovery times, defined as the time until the significant difference between the value at each time point and the baseline value disappeared, in the dynamic balance test, USW test, MSW test, and TUG test, were 80, 40, 80, 80 minutes, respectively. There was a significant and strong positive correlation between the result of the dynamic balance test in CDP and the TUG test (p < 0.01, r=0.70).Conclusion. The TUG test is a useful simple dynamic balance/motor test that can be used in daily clinical practice in the elderly.

show abstract

“…Limited data on adult population undergoing dental procedural sedation with dexmedetomidine has shown it to efficacious and safe with sufficient analgesia, but limited amnesia and prolonged recovery time [47][48][49][50] . Although generally effective for sedation for noninvasive and short procedure, dexmedetomidine as sole agent has not been uniformly successful for invasive procedures [51][52][53][54][55] . It is slowly losing the popularity as sole agent for procedural sedation due to its slow onset, delayed recovery, minimal analgesia and limited amnesia.…”

Section: Benzodiazepines (Bzd)mentioning

confidence: 99%

Changing Trends in Dental Procedural Sedation

Upadhyay¹,

Tellicherry²,

Samant³

et al. 2016

JAS

View full text Add to dashboard Cite

Dexmedetomidine vs midazolam for monitored anaesthesia care during cataract surgery

Abstract: Compared with midazolam, dexmedetomidine does not appear to be suitable for sedation in patients undergoing cataract surgery. While there was a slightly better subjective patient satisfaction, it was accompanied by relative cardiovascular depression and delayed recovery room discharge.

Cited by 157 publications

References 23 publications

Comparison of Dexmedetomidine versus Midazolam/Remifentanil Combination for Monitorized Anaesthesia Care

Comparison of Dexmedetomidine versus Midazolam/Remifentanil Combination for Monitorized Anaesthesia Care

Correlation between precise and simple tests in recovery of dynamic balance function after intravenous sedation with midazolam in the elderly

Changing Trends in Dental Procedural Sedation

Contact Info

Product

Resources

About