Dexterous Finger Movements in Primate Without Monosynaptic Corticomotoneuronal Excitation

Sasaki, Seiko; Isa, Tadashi; Pettersson, L.‐G.; Alstermark, B.; Naito, Koichiro; Yoshimura, Kazuya; Seki, Kazuhiko; Ohki, Yukari

doi:10.1152/jn.00342.2004

Cited by 174 publications

(183 citation statements)

References 17 publications

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“…In primates, many studies have evaluated functional recovery after spinal cord transection [28][29][30][31], mostly using lesions of specific funiculi to determine the role of ascending [32][33][34][35] and descending tracts, especially the corticospinal tract [12,13,[36][37][38][39][40]. In initial studies we used a low thoracic (T10) hemisection to study the effect of a unilateral corticospinal tract lesion on quadrupedal stepping and recovery of fine motor control of the hindlimbs using tasks that required dexterous foot digit movements [41,42].…”

Section: Scimentioning

confidence: 99%

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

et al. 2012

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Section: Scimentioning

confidence: 99%

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

et al. 2012

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“…In monkeys with a lesion of the direct cortico-motoneuronal pathway at the C 4 /C 5 segments, the C 3 /C 4 propriospinal neurons are supposed to play a pivotal role in the recovery of independent finger movements and precision grip (Sasaki et al 2004). In rats, the propriospinal neurons in the cervical segments make a bridge between the corticospinal tract and hindlimb motoneurons after spinal cord injury (Bareyre et al 2004).…”

Section: Possible Descending Cortical Motor Pathwaysmentioning

confidence: 99%

Formation of Descending Pathways Mediating Cortical Command to Forelimb Motoneurons in Neonatally Hemidecorticated Rats

Umeda

Takahashi

Isa

et al. 2010

Journal of Neurophysiology

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Neonatally hemidecorticated rats show fairly normal reaching and grasping behaviors of the forelimb contralateral to the lesion at the adult stage. Previous experiments using an anterograde tracer showed that the corticospinal fibers originating from the sensorimotor cortex of the intact side projected aberrant collaterals to the spinal gray matter on the ipsilateral side. The present study used electrophysiological methods to investigate whether the aberrant projections of the corticospinal tract mediated the pyramidal excitation to the ipsilateral forelimb motoneurons and, if so, which pathways mediate the effect in the hemidecorticated rats. Electrical stimulation to the intact medullary pyramid elicited bilateral negative field potentials in the dorsal horn of the spinal cord. In intracellular recordings of forelimb motoneurons, oligosynaptic pyramidal excitation was detected on both sides of the spinal cord in the hemidecorticated rats, whereas pyramidal excitation of motoneurons on the side ipsilateral to the stimulation was much smaller in normal rats. By lesioning the dorsal funiculus at the upper cervical level, we clarified that the excitation was transmitted to the ipsilateral motoneurons by at least two pathways: one via the corticospinal tract and spinal interneurons and the other via the cortico-reticulo-spinal pathways. These results suggested that in the neonatally hemidecorticated rats, the forelimb movements on the side contralateral to the lesion were modulated by motor commands through the indirect ipsilateral descending pathways from the sensorimotor cortex of the intact side either via the spinal interneurons or reticulospinal neurons.

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“…The development of the CST across different animal species relates to their degree of dexterity (Lemon and Griffiths, 2005), and, in the monkey, complete (Lawrence and Kuypers, 1968) or subtotal (Sasaki et al, 2004;Freund et al, 2006) lesions of the CST affect hand function. This is also reflected after stroke or spinal cord injury (SCI).…”

Section: Introductionmentioning

confidence: 99%

White Matter Organization in Cervical Spinal Cord Relates Differently to Age and Control of Grip Force in Healthy Subjects

Lindberg¹,

Feydy²,

Maier³

2010

J. Neurosci.

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Dexterous Finger Movements in Primate Without Monosynaptic Corticomotoneuronal Excitation

Abstract: . Dexterous finger movements in primate without monosynaptic corticomotoneuronal excitation.

Cited by 174 publications

References 17 publications

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

Formation of Descending Pathways Mediating Cortical Command to Forelimb Motoneurons in Neonatally Hemidecorticated Rats

White Matter Organization in Cervical Spinal Cord Relates Differently to Age and Control of Grip Force in Healthy Subjects

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