Dextran and hyaluronan methacrylate based hydrogels as matrices for soft tissue reconstruction

Möller, Stephanie; Weisser, Jürgen; Bischoff, Sabine; Schnabelrauch, Matthias

doi:10.1016/j.bioeng.2007.08.014

Cited by 68 publications

(38 citation statements)

References 16 publications

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“…The biocompatibility of dextranbased formulations have been extensively studied (Bos et al, 2005, De Groot et al, 2001. Recently dextran-based hydrogels have been studied as matrices in tissue engineering; no sign of inflammation was detected in in vivo experiments (Möller et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Preparation and characterization of dextran nanobubbles for oxygen delivery

Cavalli

Bisazza

Giustetto

et al. 2009

International Journal of Pharmaceutics

116

109

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Section: Discussionmentioning

confidence: 99%

Preparation and characterization of dextran nanobubbles for oxygen delivery

Cavalli

Bisazza

Giustetto

et al. 2009

International Journal of Pharmaceutics

116

109

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“…Thus, for example, crosslinkable dextran methacrylates and hyaluronan methacrylate hydrogels, which are candidates as matrices for soft-tissue reconstruction, were synthesized, showing that the in vitro degradation behavior of these kinds of hydrogels could be controlled by the polysaccharide structure and the crosslinking density. Furthermore, under in vitro conditions, these materials had no cytotoxic effects against fibroblasts, and the use of composite gels improved the adherence of cells [118].…”

Section: Porosity In Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Latest Improvements of Acrylic-Based Polymer Properties for Biomedical Applications

Serrano‐Aroca¹

2017

Acrylic Polymers in Healthcare

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Acrylic-based polymers have many currently important biomedical applications such as contact lenses, corneal prosthesis, bone cements, tissue engineering, etc. due to their excellent biocompatibility and suitable performance in mechanical properties, among many other applications. Many of these biomaterials have been approved by the US Food and Drug Administration (FDA) for various applications. However, the potential uses of these polymeric materials in the biomedical industry could be increased exponentially if some of their acrylic properties (mechanical strength, electrical and/or thermal properties, water sorption and diffusion, biological interactions, antibacterial activity, porosity, etc.) are enhanced. Thus, acrylics have been fabricated as multicomponent polymeric systems in the form of interpenetrated polymer networks or combined with other advanced materials such as fibers, nanofibers, graphene and its derivatives and/or many other kinds of nanoparticles to form composite or nanocomposite materials, which are expected to exhibit superior properties. Besides, in regenerative medicine, acrylic scaffolds need to be designed with the required extent and morphology of pores by sophisticated techniques. Even though the great advances have been achieved so far, much research has to be carried out still in order to find new strategies to improve the above-mentioned properties.

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“…For example, a series of methacrylate derivatives of dextran, functionalized dextrans and hyaluronan were synthesized by reaction with glycidyl methacrylate. Then, porous hydrogels were fabricated by adding a porogen to the curing mixture and leaching after polimerization [62]. Porogen-leaching.…”

Section: Oleogelsmentioning

confidence: 99%

“…Porogen-leaching. Uses a particulate porogen, such as crystals of sucrose [20,62], sodium chloride [30,63] or calcium carbonate added to the polymer solution, which are leached or dissolved after hydrogel formation.…”

Section: Oleogelsmentioning

confidence: 99%

Gels as Precursors of Porous Matrices for Use in Foods: a Review

Cuadros

Aguilera

2015

Food Biophysics

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Gelation is a structuring mechanism commonly used in foods to produce soft and homogeneous structures. Techniques applied in other areas of science (e.g., bioengineering, biotechnology and electronics) aims at producing wet and dried porous gel matrices and they may find applications in foods. This review describes several processes to manufacture porous structures such as scaffolding, ice templating, use of porogens, oleogelation, incorporation and entrapment of bubbles, enzymatic modifications, microfluidics and microfabrication techniques, among others. Several examples are also presented. Beyond textural properties, porous gels and sponges may be tailored in their mass transfer characteristics to achieve specific rates of release of bioactive molecules, nutrients and flavors.

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Dextran and hyaluronan methacrylate based hydrogels as matrices for soft tissue reconstruction

Cited by 68 publications

References 16 publications

Preparation and characterization of dextran nanobubbles for oxygen delivery

Preparation and characterization of dextran nanobubbles for oxygen delivery

Latest Improvements of Acrylic-Based Polymer Properties for Biomedical Applications

Gels as Precursors of Porous Matrices for Use in Foods: a Review

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