Dextromethorphan reduced fentanyl induced cough and stress hormones release. A randomized double blind controlled study

Elmenesy, Tarek M.; Hamden, Ghada Adel; Eldahab, Hesham A. Abo; El, Nevin A.

doi:10.1016/j.egja.2011.01.003

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…High doses of dextromethorphan although effective in reducing cough but could cause adverse effects such as dizziness and agitation which supports the rational of the lowest feasible dose. In another study by Elmenesy et al aimed to evaluate effects of dextromethorphan on cough, it was shown that premedication with dextromethorphan decreased the incidence and severity of fentanyl induced cough than in our study [16]. A number of pharmacological measures have been studied in an attempt to reduce this adverse phenomenon, with varying degrees of success.…”

Section: Discussionmentioning

confidence: 96%

Suppressing Effect of Dextromethorphan or Clonidine on Fentanyl- Induced Coughing: A Double- Blind, Prospective, Randomized Placebo- Controlled Study

Marashi¹

2013

J Pulm Respir Med

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Section: Discussionmentioning

confidence: 96%

Suppressing Effect of Dextromethorphan or Clonidine on Fentanyl- Induced Coughing: A Double- Blind, Prospective, Randomized Placebo- Controlled Study

Marashi¹

2013

J Pulm Respir Med

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Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis

et al. 2013

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Fentanyl-induced cough (FIC) is often observed after intravenous bolus administration of fentanyl during anesthesia induction. This meta-analysis assessed the efficacy of pharmacological and nonpharmacological interventions to reduce the incidence of FIC. We searched for randomized controlled trials comparing pharmacological or nonpharmacological interventions with controls to prevent FIC; we included 28 studies retrieved from Pub-Med, Embase, and Cochrane Library. Overall incidence of FIC was approximately 31 %. Lidocaine [odds ratio (OR) = 0.29, 95 % confidence interval (CI) 0.21–0.39], N-methyl-D-aspartate (NMDA) receptor antagonists (OR 0.09, 95 % CI 0.02–0.42), propofol (OR 0.07, 95 % CI 0.01–0.36), a2 agonists (OR 0.32, 95 % CI 0.21–0.48), b2 agonists (OR 0.10, 95 % CI 0.03–0.30), fentanyl priming (OR 0.33, 95 % CI 0.19–0.56), and slow injection of fentanyl (OR 0.25, 95 % CI 0.11–0.58)] were effective in decreasing the incidence of FIC, whereas atropine (OR 1.10, 95 % CI 0.58–2.11) and benzodiazepines (OR 2.04, 95 % CI 1.33–3.13) were not effective. This meta-analysis found that lidocaine, NMDA receptor antagonists, propofol, a2 agonists, b2 agonists, and priming dose of fentanyl were effective in preventing FIC, but atropine and benzodiazepines were not. Slow injection of fentanyl was effective in preventing FIC, but results depend on the speed of administration.

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Different interventions in preventing opioid-induced cough: a meta-analysis

et al. 2016

Journal of Clinical Anesthesia

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Dextromethorphan reduced fentanyl induced cough and stress hormones release. A randomized double blind controlled study

Cited by 3 publications

References 25 publications

Suppressing Effect of Dextromethorphan or Clonidine on Fentanyl- Induced Coughing: A Double- Blind, Prospective, Randomized Placebo- Controlled Study

Suppressing Effect of Dextromethorphan or Clonidine on Fentanyl- Induced Coughing: A Double- Blind, Prospective, Randomized Placebo- Controlled Study

Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis

Different interventions in preventing opioid-induced cough: a meta-analysis

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