Dextrose in the banked blood products does not seem to affect the blood glucose levels in patients undergoing liver transplantation

Cheng, Kwok Wai; Chen, Chao Long; Cheng, Yu; Tseng, Chin Chung; Wang, Hsiu-Po; Chen, Yaw Sen; Huang, Tung‐Liang; Eng, Hock Liew; Chiu, King-Wah; Wang, Shih Hor; Lin, Chia‐Yu; Lin, Tzu-Chao; Liu, Yueh Wei; Jawan, Bruno

doi:10.3748/wjg.v11.i18.2789

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Patients receiving many units of blood can receive a significant dextrose load. Our findings differ from Cheng et al [22] who studied glucose levels in pediatric patients undergoing liver transplantation and found no significant changes in the blood glucose levels in those receiving blood transfusion.…”

Section: Discussioncontrasting

confidence: 99%

Factors Associated with Increases in Glucose Levels in the Perioperative Period in Non-Diabetic Patients

Tilak¹,

Schoenberg²,

Castro³

et al. 2013

OJAnes

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Background: Blood glucose levels are elevated during the perioperative period as a result of the neuro-endocrine response to the stress of surgery. In nondiabetic patients, blood glucose levels are not a part of routine preoperative testing nor are they monitored during surgery or in the post anesthesia care unit (PACU). We measured blood glucose levels in nondiabetic patients during the perioperative period to identify how many patients had high glucose levels and what factors were associated with increases in blood glucose levels. Methods: This prospective observational study included two hundred and ninety five nondiabetic patients between the ages of 18 and 80 years, undergoing elective noncardiac surgery. Blood glucose levels were measured preoperatively and at frequent, predetermined intervals during surgery and in the PACU. Patient characteristics, surgical and anesthetic factors, and pain scores in the PACU were recorded, as were postoperative complications. Results: Forty nine percent (49%) of the patients had maximum intraoperative glucose levels of 126 mg/dl or higher and fifty three percent (53%) had maximum postoperative glucose levels of 126 mg/dl or higher. Preoperative glucose levels, family history of diabetes and amount of blood loss were statistically significantly associated with both max-intra-op and max-post-op glucose levels. Additionally, blood administration, surgery duration and race were significantly associated with max-intra-op glucose levels, while amount of intravenous fluids and sex were significantly associated with max-post-op glucose levels. Conclusion: A large number of nondiabetic patients in our study had maximum glucose levels >126 mg/dl in the perioperative period. Certain patient characteristics, as well as surgical/anesthetic factors, were associated with increases in the glucose levels. More studies are indicated to determine which patients may benefit from glucose monitoring in the perioperative period.

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Section: Discussioncontrasting

confidence: 99%

Factors Associated with Increases in Glucose Levels in the Perioperative Period in Non-Diabetic Patients

Tilak¹,

Schoenberg²,

Castro³

et al. 2013

OJAnes

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“…The liver plays an important role in carbohydrate metabolism and glucose homeostasis. Hyperglycemia commonly occurs during LT procedures in dogs and humans . In our rat partial LT models, hyperglycemia was not observed immediately after 70% partial LT (data not shown).…”

Section: Discussionmentioning

confidence: 61%

“…Hyperglycemia commonly occurs during LT procedures in dogs 62 and humans. 63 In our rat partial LT models, hyperglycemia was not observed immediately after 70% partial LT (data not shown). Furthermore, there was no significant difference in blood glucose levels between untreated and G-CSF/DPP-IV inhibitor combination groups at 24-72 h after partial LT (data not shown).…”

Section: G Ranulocyte Colony-stimulating Factormentioning

confidence: 63%

Prolonged survival by combined treatment with granulocyte colony‐stimulating factor and dipeptidyl peptidase IV inhibitor in a rat small‐for‐size liver transplantation model

Hsu¹,

Nakano

Huang³

et al. 2014

Hepatology Research

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“…18 The citrate and dextrose were thus sterilized separately and mixed before the blood was collected. 21 This formulation decreased the pH, allowed sterilization without caramelization, and facilitated storage for up to 21 days.…”

Section: Glucosementioning

confidence: 99%

Packed Red Blood Cells and Related Products

Campbell‐Lee

Ness

2007

Blood Banking and Transfusion Medicine

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Dextrose in the banked blood products does not seem to affect the blood glucose levels in patients undergoing liver transplantation

Cited by 9 publications

References 23 publications

Factors Associated with Increases in Glucose Levels in the Perioperative Period in Non-Diabetic Patients

Factors Associated with Increases in Glucose Levels in the Perioperative Period in Non-Diabetic Patients

Prolonged survival by combined treatment with granulocyte colony‐stimulating factor and dipeptidyl peptidase IV inhibitor in a rat small‐for‐size liver transplantation model

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