DFT vibrational assignments, in vitro antifungal activity, genotoxic and acute toxicity determinations of the [Zn(phen)2(cnge)(H2O)](NO3)2·H2O complex

Medina, Juan José Martínez; Torres, Carola Analía; Alegre, Walter S.; Franca, Carlos A.; Tévez, Libertad Leonor López; Ferrer, Evelina G.; Okulik, Nora Beatriz; Williams, Patricia Ana María

doi:10.1016/j.molstruc.2015.07.061

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…typhimurium TA100) at the tested concentrations. Besides, we previously reported that phen does not exert mutagenic action on these Salmonella strains up to a concentration of 47 μg/plate, 53 in agreement with another report that employed similar Salmonella strains 63 …”

Section: Resultssupporting

confidence: 90%

“…The antimicrobial activity of cnge against all tested strains was not relevant (MIC >1500 μg ml −1 ). The MIC values of the ligand phen were previously determined 51,53,54 and they are included in Table 3 for comparative purposes.…”

Section: Resultsmentioning

confidence: 99%

“… b MIC values of [Zn (phen) 2 (cnge)(H 2 O)](NO 3 ) 2 •H 2 O complex taken from Tévez et al 54 (bacterial strains) and from Martínez Medina et al 53 (fungal strains).…”

Section: Resultsmentioning

confidence: 99%

“…salina L. test is useful for the screening of novel drugs in order to predict their toxicity and has shown a good correlation ( r = 0.85 p < 0.05) with the assays in mice, suggesting that the brine shrimp bioassay is a useful alternative model 64 . We previously determined the mortality of brine shrimp produced by the ligand phen (93.70 μg ml −1 ) 53 . According to Clarkson's toxicity criterion, 65 this ligand is in the limit of the high toxicity, near to the medium toxicity.…”

Section: Resultsmentioning

confidence: 99%

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Computational studies, antimicrobial activity, inhibition of biofilm production, and safety profile of the cadmium complex of 1,10‐phenanthroline and cyanoguanidine

Falkievich

Medina

Alegre

et al. 2022

Applied Organom Chemis

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We have previously determined the crystal structure of the metal complex [Cd (1,10-phenanthroline) 2 (SO 4 )H 2 O]cyanoguanidine•5H 2 O that was characterized by spectroscopic measurements. The antibacterial activity was also determined by the agar diffusion test (zones of inhibition). In the present work, calculations based on density functional theory were performed to determine the contributions of the two different tautomers of cyanoguanidine to the vibrational IR and Raman experimental spectra. Moreover, the antimicrobial (antibacterial and antifungal) activity of the complex and cadmium ion was assessed and the minimum inhibitory concentration (MIC) was determined.The complexation increased the antimicrobial activity against Pseudomonas aeruginosaATCC 27853 and inhibited the biofilm production of this pathogen.Antimicrobial studies were coupled with the evaluation of safety, using the Artemia salinaand Ames test. At the concentrations tested, the cadmium complex behaved as a non-mutagenic and non-toxic compound. Therefore, the interaction of cadmium (II) with N and O-containing ligands may provide a promising strategy for the development of novel and safe drugs with antimicrobial activity.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

“… b MIC values of [Zn (phen) 2 (cnge)(H 2 O)](NO 3 ) 2 •H 2 O complex taken from Tévez et al 54 (bacterial strains) and from Martínez Medina et al 53 (fungal strains).…”

Section: Resultsmentioning

confidence: 99%