Di-(2-ethylhexyl) phthalate enhances the release of lysosomal enzymes from alveolar macrophages during phagocytosis

Bally, Marcel B.; Opheim, Dennis J.; Shertzer, Howard G.

doi:10.1016/0300-483x(80)90037-2

Cited by 24 publications

(13 citation statements)

References 25 publications

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“…It could be speculated that the reduced numbers of PAMs in these groups were linked to the observed adjuvant effect. Also, DEHP has been reported to reduce alveolar macrophage activity and even to be toxic to these groups (Bally et al, 1980;Shertzer et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice

et al. 2007

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“…Lung damage with infiltration and degranulation of polymorphonuclear leukocytes, histologically similar to protease-induced lung lesions, increased release of lysosomal enzymes from alveolar macrophages in vitro [58] as well as inhibition of the rabbit alveolar macrophage killing [59] were also observed. Alveolar macrophages are known to produce and release reactive oxygen species, while containing antioxidative enzymes [60] and a wide variety of proteases, that can cause lung damage and emphysema [58].…”

Section: Evidence Of Toxicity In Experimental Animalsmentioning

confidence: 90%

Potential Hazards of Exposure to Di-(2-Ethylhexyl)-Phthalate in Babies

Latini

2000

Neonatology

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Many plastic items are made of polyvinylchloride (PVC) blended with plasticizers. The most frequently used plasticizer is di-(2-ethylhexyl)-phthalate (DEHP). DEHP migrates at a constant rate from plastics to the environment: it has been detected in water, soil and food and is therefore considered as a widespread environmental contaminant. Over the past several years, a number of publications concerning toxic effects of DEHP on animals and humans have been reported. Although DEHP is suggested to be of low acute toxicity, long-term exposure, especially in human beings at risk such as pregnant women and children, requires more in-depth studies. If DEHP toxicity in humans were to be confirmed, it would be advisable in the future to replace current PVC plasticizers, especially if they come into contact with babies, with better-quality materials.

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“…In adult rats, moreover, respiratory distress and dose-dependent lethality occur after a single intravenous injection of 200-300 mg/ Kg Tween-solubilised DEHP (Schulz et al 1975), while a 4-week-long aerosol treatment (estimated dose 230 mg/Kg/ day) causes relative lung weight increase, accompanied by foam-cell proliferation and alveolar septa thickening (Klimisch et al 1992). DEHP-induced release of lysosomal enzymes from cultured alveolar macrophages, as well as constriction and oedema of pulmonary vessels in isolated perfused rat heart-lung preparations, has also been reported (Bally et al 1980;Shertzer et al 1982;Labow et al 1990). …”

Section: Introductionmentioning

confidence: 89%

DEHP effects on histology and cell proliferation in lung of newborn rats

Rosicarelli

Stefanini

2008

Histochem Cell Biol

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Di-(2-ethylhexyl)-phthalate (DEHP), the plasticizer employed in the fabrication of polyvinyl chloride, is known to be released by many medical devices, namely endotracheal tubes currently utilised for pulmonary ventilation of pre-term newborns. When experimentally administered, especially to rodents, the phthalate reportedly causes alterations to several tissues, immature animals being even more responsive targets than adult ones. In the present research, female rats were fed with DEHP in the last week of pregnancy and after delivery, and lung of their pups was morphologically and immunohistochemically analysed. We detected significant alveolar simplification (larger but fewer alveoli with decreased septation), with consequent sensible reduction of gas-exchange surface, at several stages of postnatal development, in distal lung parenchyma of DEHP-treated rats. Moreover, the quantification of PCNA-expressing cells demonstrates that in treated pups the proliferation rates of epithelial and mesenchymal cells progressively increased during the first two postnatal weeks, at difference with controls animals, where the highest proliferation levels were reached at postnatal day 7. The obtained results strongly support the hypothesis that DEHP profoundly affects the alveolarization process in mammalian lung.

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Di-(2-ethylhexyl) phthalate enhances the release of lysosomal enzymes from alveolar macrophages during phagocytosis

Cited by 24 publications

References 25 publications

Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice

Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl)phthalate and ovalbumin in BALB/c mice

Potential Hazards of Exposure to Di-(2-Ethylhexyl)-Phthalate in Babies

DEHP effects on histology and cell proliferation in lung of newborn rats

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