Di-(2-ethylhexyl) phthalate induced developmental abnormalities of the ovary in quail (Coturnix japonica) via disruption of the hypothalamic-pituitary-ovarian axis

Li, Xue-Nan; Li, Huixin; Yang, Tian-Ning; Li, Xiaowei; Huang, Yue-Qiang; Zhu, Shi-Yong; Li, Jinlong

doi:10.1016/j.scitotenv.2020.140293

Cited by 58 publications

(27 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Section of testis showed a complete absence of spermatids and stopping the spermatogenesis process; these results were found agreed with many articles that showed DEHP produced testicular toxicity and damages to tubules and spermatogenesis in all stages; also, DEHP induces vacuolar degeneration in Sertoli and Leydig cells (23). Section of quail's ovary showed complete absence of primordial follicles which consider the first step in developing follicles with hemorrhages, vacuolar degeneration in granular cell of interstitial tissue with infiltration of inflammatory cells, these result can be explained by the effect of MEHP the main metabolic of DEHP that cause decrease and stop estradiol production from ovary the activate peroxisomes receptors in the granulosa cells of developing follicles cause them to undergo apoptosis, all these outcomes suggest that the primary site of toxicity for DEHP is the granulosa cell of growing pre-ovulatory follicles which cause complete absent of these primordial follicles and lead to cystic ovary in cases where the exposure occur after puberty, on other hand the ovary from quails were they exposed to DEHP since one day old their ovary showed complete absent of growing and ovulatory follicles (24), the same results were have been recorded by other studies (25,26) in which the vacuolar degeneration in granular cell layer of ovary with hemorrhage are the most significant outcomes in DEHP toxicity in rats.…”

Section: Discussionsupporting

confidence: 77%

Effect DEHP plasticizer on MDA concentration and histopathological changes in Contronix contronix japonica

Hamoodi¹,

Al-Mahmood²

2022

IJVS

View full text Add to dashboard Cite

In this experiment, we aimed to recorded the effect of chronic oral exposure to DEHP on lipid peroxidation and histopathological lesions induced in different organs. A total of 150 quail chick divided into two groups (75 quail's chicks at each group), control group left without any treatment all time, the second group was orally administrated 5% of DEHP (278.05 mg/kg bw) three times per week and lasted for 60 days. At 30 and 60 days old, a total number of 25 from both groups were euthanized. Blood samples were collected to determine the serum concentration of DEHP and mono ethyl hexyl phthalate (MEHP), liver and kidney to estimate tissue concentration of malondialdehyde (MDA), samples from different organs for histopathological examination. The result showed that the concentration of DEHP and MEHP in blood's serum and concentration of MDA in liver and kidney significantly increased with time in comparison with the control group; besides, oral administration of DEHP induced sever pathological lesions, in brain, aorta, intestines, liver, lung, ovary and testis. In conclusion, the DEHP and its metabolic product MEHP significantly increased in serum and cause significant increase in concertation of MDA in liver and kidney tissues, produces a significant histopathological change in brain, aorta, liver, intestine, lung, ovary and testis that can cause a life-threatening condition.

show abstract

Section: Discussionsupporting

confidence: 77%

Effect DEHP plasticizer on MDA concentration and histopathological changes in Contronix contronix japonica

Hamoodi¹,

Al-Mahmood²

2022

IJVS

View full text Add to dashboard Cite

show abstract

“…42,43 ATZ, which is used widely in the agricultural sector, has been recognized as a toxic environmental pollutant for humans. 22 Previous studies have determined that ATZ exposure disturbs the splenic homeostasis by inducing the apoptosis of splenocytes. 21,28 Lyc prevented the damage of ATZ-induced in different tissues via mice and rats.…”

Section: Discussionmentioning

confidence: 99%

“…See DOI: 10.1039/d1fo02857j Some studies have found that ATZ could induce inflammation in some tissues. [22][23][24] In addition, ATZ exposure can result in ROS generation and accumulation in its target organs. Thus, it could be hypothesized that ATZ induced the activation of Nlrp3, which could trigger autoinflammatory and metabolic disorders in human.…”

Section: Introductionmentioning

confidence: 99%

Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway

Zhu

Guo

et al. 2022

Food Funct.

Self Cite

View full text Add to dashboard Cite

show abstract

“…It induced ovarian toxicity by inhibition of follicular development and abnormal steroid hormone synthesis in cultured rat ovarian follicles 85 . It also inhibited the rat granulosa cell viability, increased apoptosis through caspase‐3 activation and Bcl‐2‐associated x protein (BAX) expression, stimulated steroid hormone secretion, and induced the expression of key enzymes in progesterone expression and sex hormone receptors 86‐88 …”

Section: Effects Of Phthalate On Granulosa Cellsmentioning

confidence: 99%

“…Moreover, DEHP affected the anti‐apoptosis function of KIT ligand (KITL) and growth differentiation factor‐9 (GDF‐9) and increased the BAX/ BCL2 expression ratio to promote apoptosis of the granulosa cells 95 . Recently, Li et al 88 demonstrated that quails fed on DEHP showed mitochondrial damage and decreased thickness of the ovarian granulosa cell layer, along with oxidative stress.…”

Section: Effects Of Phthalate On Granulosa Cellsmentioning

confidence: 99%

The impact of phthalate on reproductive function in women with endometriosis

Chou

Tzeng

2021

Reprod Medicine & Biology

View full text Add to dashboard Cite

Background Endometriosis is a common gynecological condition in which stromal or glandular epithelium is implanted in extrauterine locations. Endometriosis causes detrimental effects on the granulosa cells, and phthalate interferes with the biological and reproductive function of endometrial cells at a molecular level. Methods This article retrospectively reviewed the studies on phthalate exposure and its relationship with endometriosis. A literature search was performed for scientific articles using the keywords “phthalate and endometriosis,” “endometriosis and granulosa cells,” “phthalate and granulosa cells,” and “phthalates and endometrial cells.” Results Endometriosis can affect cytokine production, steroidogenesis, cell cycle progression, expression of estrogen receptor‐α (ER‐α)/progesterone receptor (PR), and cause endoplasmic reticulum stress, senescence, apoptosis, autophagy, and oxidative stress in the granulosa cells. Mono‐n‐butyl phthalate (MnBP) alters the expression of cytokines, cell cycle‐associated genes, ovarian stimulation, steroidogenesis, and progesterone production. Several in vitro studies have demonstrated that phthalate caused inflammation, invasion, change in cytokines, increased oxidative stress, viability, resistance to hydrogen peroxide, and proliferation of endometrial cells. Conclusion This might provide new insights about the impact of phthalate on the pathogenesis of endometriosis and its consequences on the ovarian function.

show abstract

Di-(2-ethylhexyl) phthalate induced developmental abnormalities of the ovary in quail (Coturnix japonica) via disruption of the hypothalamic-pituitary-ovarian axis

Cited by 58 publications

References 67 publications

Effect DEHP plasticizer on MDA concentration and histopathological changes in Contronix contronix japonica

Effect DEHP plasticizer on MDA concentration and histopathological changes in Contronix contronix japonica

Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway

The impact of phthalate on reproductive function in women with endometriosis

Contact Info

Product

Resources

About