Di-n-amyl l-tartrate–boric acid complex chiral selector in situ synthesis and its application in chiral nonaqueous capillary electrophoresis

Wang, Limin; Hu, Shaoqiang; Qiao-ling, Guo; Yang, Gengliang; Chen, Xingguo

doi:10.1016/j.chroma.2011.01.003

Cited by 33 publications

(21 citation statements)

References 29 publications

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“…Changing the configuration of tartaric acid led to a reversal of the enantiomer migration order of the analytes. The di-namyl-L-tartrate boric acid complex also proved to be an efficient chiral selector in non-aqueous CE [71]. The background electrolyte consisted of triethylamine in methanol.…”

Section: New Chiral Selectors and Mechanistic Modelsmentioning

confidence: 99%

Chiral electromigration techniques in pharmaceutical and biomedical analysis

Scriba

2011

Bioanal Rev

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Capillary electromigration techniques are often considered ideal methods for enantioseparations due to their high separation selectivity and flexibility. Thus, numerous methods employing a chiral selector as pseudostationary phase in a background electrolyte have been developed and applied for the chiral analysis of drugs in bulk ware, pharmaceutical formulations and biological matrices. Furthermore, electromigration techniques have been combined with spectroscopic methods such as nuclear magnetic resonance in order to understand the complexation of analytes by chiral selectors. The present review focuses on recent developments and applications of chiral electromigration techniques in pharmaceutical and biomedical analysis including examples illustrating analyte-selector complex formation or mechanistic studies which have been published between January 2009 and July 2011. Selector-mediated chiral separations clearly dominate while no applications of capillary electrochromatography to pharmaceutical or biomedical analysis have been reported during this period of time.

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Section: New Chiral Selectors and Mechanistic Modelsmentioning

confidence: 99%

Chiral electromigration techniques in pharmaceutical and biomedical analysis

Scriba

2011

Bioanal Rev

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“…A new tartrate–borate complex composed of di‐ n ‐amyl‐ L ‐tartrate and boric acid proved to be an efficient chiral selector in nonaqueous CE . Optimized enantioseparations of β‐blockers and β‐agonists were achieved using 80 mM di‐ n ‐amyl‐ L ‐tartrate, 100 mM boric acid and 50 mM triethylamine in methanol.…”

Section: New Chiral Selectors In Cementioning

confidence: 99%

Recent advances in electrodriven enantioseparations

Jáč

Scriba

2012

J of Separation Science

110

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Capillary electromigration techniques have developed into significant analytical separation tools especially for enantioseparations. While CE can be considered a mature technique as documented by its wide applications, CEC is still in a developmental state despite many research efforts. The success of stereospecific CE separation methods is due to the high specificity and flexibility of the technique as well as the availability of many types of chiral selectors. Thus, numerous methods have been developed for the analysis of chiral compounds in chemical, biochemical, pharmaceutical, environmental, and forensic sciences. However, most reported applications deal with pharmaceuticals. The search for new chiral selectors also continued despite the fact that most applications were performed using cyclodextrins. Furthermore, CE has been combined with spectroscopic and molecular modeling studies in attempts to understand the interactions between chiral selectors and analytes. The present review focuses on recent examples of mechanistic aspects of capillary enantioseparations with regard to mathematical modeling of enantioseparations, investigations of the analyte-complex structures as well as new chiral selectors and applications of chiral analyses by CE and CEC. It covers the literature published between January 2011 and August 2012.

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“…The development of chiral separation methods has attracted great attention during the past two decades, on both analytical and preparative aspect [1][2][3]. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer).…”

Section: Introductionmentioning

confidence: 99%