Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure

Neglia, Cosimo; Argentiero, Alberto; Chitano, Giovanna; Agnello, Nadia; Ciccarese, Roberta; Vigilanza, Antonella; Pantile, V.; Argentiero, D.; Quarta, Raffaele; Rivezzi, Matteo; Tanna, Gian Luca Di; Somma, Carolina Di; Migliore, Alberto; Iolascon, Giovanni; Gimigliano, Francesca; Distante, Alessandro; Piscitelli, Prisco

doi:10.3390/ijerph13111067

Cited by 34 publications

(28 citation statements)

References 39 publications

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“…In the current study, we found that adults with CP had a higher prevalence of fracture across all regions of the body compared with adults without CP. We also found that the odds of any fracture was more than 2 times higher among adults with CP, even after adjusting for cardiometabolic diseases, which are more prevalent in the adult CP population and are associated with skeletal fragility in the non‐CP population . Another important factor for fracture risk is osteoporosis.…”

Section: Discussionmentioning

confidence: 70%

“…We also found that the odds of any fracture was more than 2 times higher among adults with CP, even after adjusting for cardiometabolic diseases, which are more prevalent in the adult CP population (30) and are associated with skeletal fragility in the non-CP population. (42,43) Another important factor for fracture risk is osteoporosis. We have previously reported that the prevalence of osteoporosis is similar among young adults with CP (18 to 30 years) as compared with the general population of adults !50 years of age, (35) and becomes progressively more prevalent throughout the adult CP lifespan.…”

Section: Discussionmentioning

confidence: 99%

“…Covariates were selected based on their relevance to adults with CP, fracture, and availability in the administrative claims database . Sociodemographic and socioeconomic variables included age, sex, ethnic group, and education level.…”

Section: Methodsmentioning

confidence: 99%

“…Covariates were selected based on their relevance to adults with CP, fracture, and availability in the administrative claims database. (30,36,42,43) Sociodemographic and socioeconomic variables included age, sex, ethnic group, and education level. We have previously reported that adults with CP had a higher prevalence of cardiometabolic diseases and osteoporosis compared with adults without CP.…”

Section: Covariatesmentioning

confidence: 99%

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Adults with Cerebral Palsy have Higher Prevalence of Fracture Compared with Adults Without Cerebral Palsy Independent of Osteoporosis and Cardiometabolic Diseases

Whitney

Alford

Devlin

et al. 2019

Journal of Bone and Mineral Research

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Individuals with cerebral palsy (CP) have an increased risk of fracture throughout their lifespan based on an underdeveloped musculoskeletal system, excess body fat, diminished mechanical loading, and early development of noncommunicable diseases. However, the epidemiology of fracture among adults with CP is unknown. The purpose of this cross‐sectional study was to determine the prevalence of fracture among a large sample of privately insured adults with CP, as compared with adults without CP. Data were from the Optum Clinformatics Data Mart (Eden Prairie, MN, USA), a deidentified nationwide claims database of beneficiaries from a single private payer. Diagnostic codes were used to identify 18‐ to 64‐year‐old beneficiaries with and without CP and any fracture that consisted of osteoporotic pathological fracture as well as any type of fracture of the head/neck, thoracic, lumbar/pelvic, upper extremity, and lower extremity regions. The prevalence of any fracture was compared between adults with (n = 5,555) and without (n = 5.5 million) CP. Multivariable logistic regression was performed with all‐cause fracture as the outcome and CP group as the primary exposure. Adults with CP had a higher prevalence of all‐cause fracture (6.3% and 2.7%, respectively) and fracture of the head/neck, thoracic, lumbar/pelvic, upper extremity, and lower extremity regions compared with adults without CP (all p < 0.01). After adjusting for sociodemographic and socioeconomic variables, adults with CP had higher odds of all‐cause fracture compared with adults without CP (OR 2.5; 95% CI, 2.2 to 2.7). After further adjusting for cardiometabolic diseases, adults with CP had higher odds of all‐cause fracture compared with adults without CP (OR 2.2; 95% CI, 2.0 to 2.5). After further adjusting for osteoporosis, adults with CP still had higher odds of all‐cause fracture compared with adults without CP (OR 2.0; 95% CI, 1.8 to 2.2). These findings suggest that young and middle‐aged adults with CP have an elevated prevalence of all‐cause fracture compared with adults without CP, which was present even after accounting for cardiometabolic diseases and osteoporosis. © 2019 American Society for Bone and Mineral Research.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Covariatesmentioning

confidence: 99%

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Adults with Cerebral Palsy have Higher Prevalence of Fracture Compared with Adults Without Cerebral Palsy Independent of Osteoporosis and Cardiometabolic Diseases

Whitney

Alford

Devlin

et al. 2019

Journal of Bone and Mineral Research

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“…The average performance from two trials using the participants' dominant hand was used as the result for analysis. Since lifestyle is important to physical and health status [18][19][20], information on alcohol drinking (≥ 40 g/day in men, ≥ 20 g/day in women), current smoking (yes/no), exercise (at least 30 min twice per week), and menopause (yes/no only in women) was collected by interview.…”

Section: Methodsmentioning

confidence: 99%

Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women

Tanaka

Arima

Nishimura

et al. 2020

J Physiol Anthropol

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Background: An increase in serum undercarboxylated osteocalcin concentrations suggests vitamin K deficiency. Clinical intervention studies suggested that the vitamin K supplementation might contribute to preventing bone loss in postmenopausal women. Evidence on the relationship between serum undercarboxylated osteocalcin (ucOC) levels and bone parameters of quantitative ultrasound (QUS) is limited. We examined the correlation between serum ucOC concentrations and bone status as measured by QUS among middle-aged and older Japanese men and women. Methods: The subjects were community-dwelling men (n = 358) and women (n = 503) aged ≥ 40 years in Japan. Heel QUS parameters, including the stiffness index, speed of sound, and broadband ultrasound attenuation, were measured. Serum ucOC concentrations were measured by electrochemiluminescence immunoassay. Grip strength was measured in the dominant hand. Information on alcohol drinking, current smoking, exercise, and menopause in women was collected. Results: Serum ucOC concentrations were significantly associated with age in both sexes. Serum ucOC concentrations in men were higher at ≥ 80 years than those in the age groups of 40-49, 50-59, and 60-69 years. Serum ucOC concentrations in women were higher in the age groups of 50-59 and 60-69 years than those at 40-49 years. Partial correlation analysis adjusting for covariates (age, body mass index, grip strength, alcohol drinking, current smoking, and exercise in men; age, body mass index, grip strength, alcohol drinking, current smoking, exercise, and menopause in women) showed that serum ucOC concentrations were negatively significantly correlated with all QUS parameters in women. Serum ucOC concentrations were not correlated with them in men. Conclusions: Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women.

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Exogenous melatonin prevents type 1 diabetes mellitus–induced bone loss, probably by inhibiting senescence

Gong

Tian

et al. 2021

Osteoporos Int

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Exogenous melatonin inhibited the senescence of preosteoblast cells in type 1 diabetic (T1D) mice and those cultured in high glucose (HG) by multiple regulations. Exogenous melatonin had a protective effect on diabetic osteoporosis, which may depend on the inhibition of senescence. Introduction Senescence is thought to play an important role in the pathophysiological mechanisms underlying diabetic bone loss. Increasing evidence has shown that melatonin exerts anti-senescence effects. In this study, we investigated whether melatonin can inhibit senescence and prevent diabetic bone loss. Methods C57BL/6 mice received a single intraperitoneal injection of 160 mg/kg streptozotocin, followed by the oral administration of melatonin or vehicle for 2 months. Then, tissues were harvested and subsequently examined. MC3T3-E1 cells were cultured under HG conditions for 7 days and then treated with melatonin or not for 24 h. Sirt1-specific siRNAs and MT1-or MT2-specific shRNA plasmids were transfected into MC3T3-E1 cells for mechanistic study. Results The total protein extracted from mouse femurs revealed that melatonin prevented senescence in T1D mice. The micro-CT results indicated that melatonin prevented bone loss in T1D mice. Cellular experiments indicated that melatonin administration prevented HG-induced senescence, whereas knockdown of the melatonin receptors MT1 or MT2 abolished these effects. Sirt1 expression was upregulated by melatonin administration but significantly reduced after MT1 or MT2 was knocked down. Knockdown of Sirt1 blocked the anti-senescence effects of melatonin. Additionally, melatonin promoted the expression of CDK2, CDK4, and CyclinD1, while knockdown of MT1 or MT2 abolished these effects. Furthermore, melatonin increased the expression of the polycomb repressive complex (PRC), but knockdown of MT1 or MT2 abolished these effects. Furthermore, melatonin increased the protein levels of Sirt1, PRC1/2 complex-, and cell cycle-related proteins. Conclusion This work shows that melatonin protects against T1D-induced bone loss, probably by inhibiting senescence. Targeting senescence in the investigation of diabetic osteoporosis may lead to novel discoveries.

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Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure

Cited by 34 publications

References 39 publications

Adults with Cerebral Palsy have Higher Prevalence of Fracture Compared with Adults Without Cerebral Palsy Independent of Osteoporosis and Cardiometabolic Diseases

Adults with Cerebral Palsy have Higher Prevalence of Fracture Compared with Adults Without Cerebral Palsy Independent of Osteoporosis and Cardiometabolic Diseases

Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women

Exogenous melatonin prevents type 1 diabetes mellitus–induced bone loss, probably by inhibiting senescence

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