Diabetes and Other Comorbidities: Microvascular and Macrovascular Diseases Diabetes and Cancer

Nithya, V.; Sangavi, P.; Srinithi, R.; Nachammai, K. T.; Kumar, S. Gowtham; Prabu, D; Kulanthaivel, Langeswaran

doi:10.1007/978-981-19-0027-3_2

Cited by 8 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disease’s alarming increase in global incidence over the past few decades has made it a prominent public health issue in the 21st century. , One of the most common types of DM is noninsulin-dependent diabetes, commonly known to be type 2 diabetes (T2DM), which happens due to insulin resistance. Four hundred twenty-two million people worldwide were estimated to have diabetes as of 2014, up from 108 million in 1980 in the WHO report. , Furthermore, DM currently ranks as the seventh leading disease in mortality rate worldwide. , Individuals diagnosed with diabetes may incur various issues as a result of blood vessel impairment and harm to multiple body organs, such as the heart, nerves, kidneys, and eyes. − The most chemotherapeutic strategy used for managing DM is to regulate postprandial blood glucose levels by blocking the primary enzymes that are responsible for carbohydrate hydrolysis such as α-glucosidase and α-amylase enzymes. − Both enzymes are essential for the decomposition of disaccharides and sugars, as well as the assimilation of glucose. In addition, the enzymes have the ability to break down polysaccharides into glucose and maltose; through this process, the body glucose level and the negative impact of the disease increase. , Therefore, it is thought that inhibiting α-glucosidase and α-amylase is a useful tactic in the management of T2DM.…”

Section: Introductionmentioning

confidence: 99%

“…5 , 6 Individuals diagnosed with diabetes may incur various issues as a result of blood vessel impairment and harm to multiple body organs, such as the heart, nerves, kidneys, and eyes. 7 − 13 The most chemotherapeutic strategy used for managing DM is to regulate postprandial blood glucose levels by blocking the primary enzymes that are responsible for carbohydrate hydrolysis such as α-glucosidase and α-amylase enzymes. 14 − 16 Both enzymes are essential for the decomposition of disaccharides and sugars, as well as the assimilation of glucose.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Discovery of Novel and Selective Schiff Base Inhibitors as a Key for Drug Synthesis, Molecular Docking, and Pharmacological Evaluation

Khan,

Rehman,

Rasheed

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a chronic disorder and still a challenge throughout the world, and therefore the search for safe and effective inhibitors for αamylase and α-glucosidase is increasing day by day. In this work, we try to carry out the synthesis, modification, and computer-aided results of and biological research on thiadiazole-based Schiff base derivatives and evaluate their in vitro α-amylase and αglucosidase inhibitory potential (1−15). In the current series, all of the synthesized analogues were shown to have potential inhibitory effects on targeted enzymes. The IC 50 values for α-amylase values ranged from 20.10 ± 0.40 to 0.80 ± 0.05 μM, compared with the standard drug acarbose having an IC 50 value of 10.30 ± 0.20 μM, while for αglucosidase, the IC 50 values ranged from 20.10 ± 0.50 to 1.20 ± 0.10 μM, compared to acarbose with an IC 50 value of 9.80 ± 0.20 μM. For better understanding, a SAR investigation was undertaken. In this series, nine scaffolds (1, 2, 3, 6, 9, 10, 11, 13, and 15) were more active than the reference drug and the docking parameter RMSD values for α-

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Discovery of Novel and Selective Schiff Base Inhibitors as a Key for Drug Synthesis, Molecular Docking, and Pharmacological Evaluation

Khan,

Rehman,

Rasheed

et al. 2024

ACS Omega

View full text Add to dashboard Cite

show abstract

Computational Approaches to Elucidate the Mechanism of Serine–Threonine Kinase (AKT1) Inhibition by Streptococcus pyogenes Exotoxin Superantigen‐Derived Peptides: Pioneering Cancer Therapy

Kathiresan,

Jayaprakash,

Langeswaran

2024

Peptide Science

View full text Add to dashboard Cite

A serine–threonine kinase 1 (AKT1) plays a significant role in biological processes, including cell division, survival, glucose metabolism, and apoptosis pathway. It interacts with numerous growth factors and external stimuli, and numerous types of human cancer have been associated with its activation. Bacterial toxins have the potential to eradicate tumors and can be utilized for producing bacterial‐based cancer vaccines. One of the few bacterial species recognized for producing superantigen exotoxins is Streptococcus pyogenes. Superantigen produced by S. pyogenes, exotoxins such as SPEA, SPEB, and SPEC, which activate CD4+ cells and cause the release of cytokines. This study aims to explore various computational methods for inhibiting AKT1 using exotoxin peptides from S. pyogenes, specifically SPEA, SPEB, and SPEC. Identified peptides were analyzed for allergencity, toxicity, hemolytic, physicochemical, and anticancer potential using computational tools The peptides were modeled using PEP‐FOLD and validated with Ramachandran plot analysis using the Procheck server. Protein–peptide docking was conducted using HDOCK, followed by an analysis of the binding free energies of the complexes. Molecular dynamics simulations were employed to investigate structural changes within AKT1‐peptide complexes. Results indicate that the identified anticancer peptide demonstrates strong binding affinities and favorable interaction profiles with AKT1. The stability observed throughout simulations suggests potential anticancer effects mediated through these peptide complexes.

show abstract

Diabetes Treatment and Prevention Using Herbal Medicine

Yusuf,

Abdulsalam,

Sabiu

2023

Reference Series in Phytochemistry

View full text Add to dashboard Cite

Diabetes and Other Comorbidities: Microvascular and Macrovascular Diseases Diabetes and Cancer

Cited by 8 publications

References 51 publications

Discovery of Novel and Selective Schiff Base Inhibitors as a Key for Drug Synthesis, Molecular Docking, and Pharmacological Evaluation

Discovery of Novel and Selective Schiff Base Inhibitors as a Key for Drug Synthesis, Molecular Docking, and Pharmacological Evaluation

Computational Approaches to Elucidate the Mechanism of Serine–Threonine Kinase (AKT1) Inhibition by Streptococcus pyogenes Exotoxin Superantigen‐Derived Peptides: Pioneering Cancer Therapy

Diabetes Treatment and Prevention Using Herbal Medicine

Contact Info

Product

Resources

About