Diabetes and rheumatic diseases

Burner, Todd; Rosenthal, Ann K.

doi:10.1097/bor.0b013e32831bc0c4

Cited by 90 publications

(74 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[12] Rheumatic disorders in DM have been associated with disease duration, degree of metabolic control, and the presence of end organ damage. [13,14,15] The concurrent effect of advanced age in patients with type 2 diabetes mellitus must be considered. Aging tendons and ligaments are subjected to degenerative changes, whereby the number of tendon cells per unit of surface area is decreased, the tenocytes become slender, and there is reduced protein synthesis in the organelles, particularly in the rough endoplasmic reticulum.…”

Section: Discussionmentioning

confidence: 99%

The Musculoskeletal Manifestations of Type 2 Diabetes Mellitus in a Kashmiri Population

Bhat

Dhar

Dar

et al. 2016

IJHS

View full text Add to dashboard Cite

Objectives: Diabetes mellitus (DM), is affecting an ever increasing number of people worldwide. Diabetes is associated with several musculoskeletal manifestations. These may involve, the upper as well as the lower limb. We conducted this study to find out the prevalence of musculoskeletal problems in type 2 diabetics in the Kashmiri population. Methodology:The study was conducted on 403 patients with diabetes and 300 controls. All patients underwent screening for any musculoskeletal abnormalities. The patients with musculoskeletal abnormalities were further assessed to find the exact diagnosis according to predefined criteria. Results:The hand was involved in 80 patients [19.8%] in the diabetic group and 15 (5%) patients of the control group. The elbow was affected in 56 patients [14%] in the diabetic group and 24 patients [5.9%] in the non-diabetic group. The shoulder involvement was diagnosed in 61 patients [15%] on the diabetic cohort and 15 patients in the non-diabetic cohort. All the upper limb figures showed a statistically significant difference i.e. P value <0.05. Conclusion:The prevalence of musculoskeletal complications in type 2 diabetics in Kashmir is quite high.

show abstract

Section: Discussionmentioning

confidence: 99%

The Musculoskeletal Manifestations of Type 2 Diabetes Mellitus in a Kashmiri Population

Bhat

Dhar

Dar

et al. 2016

IJHS

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus is a systemic disease that causes premature degeneration in virtually every organ, including the eyes, heart, kidneys, blood vessels, central and peripheral nervous systems, and joints [1][2][3][4][5]. Diabetes mellitus is an important aetiological factor in premature intervertebral disc degeneration [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Dose- and time-dependent effect of high glucose concentration on viability of notochordal cells and expression of matrix degrading and fibrotic enzymes

Park

2013

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Purpose Diabetes mellitus is an important aetiological factor in intervertebral disc degeneration. The disappearance of notochordal cells in the nucleus pulposus is thought to be the starting point for intervertebral disc degeneration. A cellular effect of diabetes mellitus on apoptosis of notochordal cells and intervertebral disc degeneration has been recently reported. However, how the duration and severity of diabetes mellitus affects viability of notochordal cells and intervertebral disc degeneration is still unknown . Methods Rat notochordal cells were isolated, cultured, and placed in either 10 % foetal bovine serum (FBS) (normal control) or 10 % FBS plus three different high glucose concentrations (0.1 M, 0.2 M, and 0.4 M) (experimental conditions) for one, three, five and seven days, respectively. We identified and quantified the degree of proliferation and apoptosis, caspase activities, and cleavages of Bid and cytochrome-c. In addition, we examined the cells for expression of matrix metalloproteinases (MMPs) and their tissue inhibitors of metalloproteinases (TIMPs). Results Each three high glucose concentrations significantly decreased proliferation and increased apoptosis of notochordal cells from culture days one to seven in a dose-dependent manner. Compared with those of 10 % FBS, caspase-9 and -3 activities and cleavage of Bid and cytochrome-c were significantly increased in each three high glucose concentrations, accompanied by increased expression of MMP-1, -2, -3, -7, -9, and -13 and TIMP-1 and -2. Conclusions High glucose concentration significantly decreased proliferation and increased apoptosis of notochordal cells via the intrinsic pathway with dose-and time-dependent effects. We also found that expression of MMPs and TIMPs was increased with dose-and time-dependent effects. Therefore, these results suggest that aggressive glucose control from an early stage of diabetes mellitus should be recommended to prevent or limit intervertebral disc degeneration.

show abstract

“…For instance, a significant positive correlation was found between elevated blood glucose and radiological evidence of OA [Hart et al, 1995]. Accordingly, OA is increasingly envisaged as a ''metabolic disorder'' linked to obesity, diabetes mellitus, dyslipidemia, hypertension, and insulin resistance [Sturmer et al, 2001;Burner and Rosenthal, 2009;Siviero et al, 2009;Pallu et al, 2010;Velasquez and Katz, 2010].These conditions seem to favor the initiation and progression of arthritic diseases, such as OA, by providing catabolic signals that lead, among other responses, to increased production of proteolytic enzymes. These degrade the matrix components causing progressive cartilage destruction, the main feature of OA [Martel-Pelletier et al, 2008;Goldring and Marcu, 2009].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes

et al. 2011

View full text Add to dashboard Cite

Cartilage matrix homeostasis involves a dynamic balance between numerous signals that modulate chondrocyte functions. This study aimed at elucidating the role of the extracellular glucose concentration in modulating anabolic and catabolic gene expression in normal and osteoarthritic (OA) human chondrocytes and its ability to modify the gene expression responses induced by pro-anabolic stimuli, namely Transforming Growth Factor-b (TGF). For this, we analyzed by real time RT-PCR the expression of articular cartilage matrix-specific and nonspecific genes, namely collagen types II and I, respectively. The expression of the matrix metalloproteinases (MMPs)-1 and -13, which plays a major role in cartilage degradation in arthritic conditions, and of their tissue inhibitors (TIMP) was also measured. The results showed that exposure to high glucose (30 mM) increased the mRNA levels of both MMPs in OA chondrocytes, whereas in normal ones only MMP-1 increased. Collagen II mRNA was similarly increased in normal and OA chondrocytes, but the increase lasted longer in the later. Exposure to high glucose for 24 h prevented TGF-induced downregulation of MMP-13 gene expression in normal and OA chondrocytes, while the inhibitory effect of TGF on MMP-1 expression was only partially reduced. Other responses were not significantly modified. In conclusion, exposure of human chondrocytes to high glucose, as occurs in vivo in diabetes mellitus patients and in vitro for the production of engineered cartilage, favors the chondrocyte catabolic program. This may promote articular cartilage degradation, facilitating OA development and/or progression, as well as compromise the quality and consequent in vivo efficacy of tissue engineered cartilage. J. Cell. Biochem. 112: 2813Biochem. 112: -2824Biochem. 112: , 2011. ß 2011 Wiley-Liss, Inc. KEY WORDS: COLLAGEN; GENE EXPRESSION; GLUCOSE; HUMAN CHONDROCYTE; MMP; OSTEOARTHRITIS; TIMPA rticular cartilage is a specialized connective tissue that supports and distributes loads and ensures a near-frictionless motion in joints. These unique properties are due to the structural organization of the main macromolecules that compose the cartilage extracellular matrix, namely collagens and proteoglycans. Chondrocytes, the only cell type present in articular cartilage, are embedded in the extracellular matrix and are responsible for maintaining its homeostasis by ensuring the synthesis and turnover of its components [Martel-Pelletier et al., 2008;Goldring and Marcu, 2009].Cartilage matrix homeostasis involves a dynamic balance between a variety of signals that modulate chondrocyte functions, namely mechanical forces, cytokines and growth factors and cellmatrix interactions, some favoring an anabolic program and others stimulating catabolic responses. Aging and mechanical stress of joints are major risk factors for osteoarthritis (OA), but growing evidence indicates that metabolic factors play an important role in disease development and progression. For instance, a significant positive correlation wa...

show abstract

Diabetes and rheumatic diseases

Abstract: Incremental progress has been made in understanding the interactions between diabetes and common musculoskeletal syndromes. Although this review highlights exciting areas of future interest, more work in this field is certainly warranted.

Cited by 90 publications

References 37 publications

The Musculoskeletal Manifestations of Type 2 Diabetes Mellitus in a Kashmiri Population

The Musculoskeletal Manifestations of Type 2 Diabetes Mellitus in a Kashmiri Population

Dose- and time-dependent effect of high glucose concentration on viability of notochordal cells and expression of matrix degrading and fibrotic enzymes

Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes

Contact Info

Product

Resources

About