Diabetes Dyslipidemia

Schofield, Jonathan; Liu, Yifen; Rao-Balakrishna, Prasanna; Malik, Rayaz A.; Soran, Handrean

doi:10.1007/s13300-016-0167-x

Cited by 340 publications

(283 citation statements)

References 136 publications

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“…In type II diabetes, this process is driven by insulin resistance, which causes a rise in free fatty acids in the serum, leading to increased chylomicron and VLDL production in both fasting and nonfasting states. In poorly controlled type I diabetes, insulin deficiency plays a similar role to increase fatty acid release from adipose tissue [2]. …”

Section: Diabetic Dyslipidemiamentioning

confidence: 99%

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Towards more specific treatment for diabetic dyslipidemia

Rodríguez

Newman

Schwartzbard

2018

Current Opinion in Lipidology

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Purpose of review Treatment of diabetic dyslipidemia is necessary because of its impact on cardiovascular disease, which is the leading cause of death in patients with diabetes. In the past, standard treatment of diabetic dyslipidemia focused only on correcting lipids. Although this remains the mainstay of treatment, because new antihyperglycemic treatments reduce cardiovascular events with minimal effect on dyslipidemia, a new approach is both timely and relevant. Recent findings LDL-lowering remains the focus of treatment for diabetic dyslipidemia, especially in patients with both diabetes and cardiovascular disease (CVD). Higher intensity statin therapy or lower LDL cholesterol goals are recommended in these patients. Combination therapy, especially with ezetimibe, fibrates, bile acid sequestrants, PCSK9 inhibitors and omega 3 fatty acids should be considered along with selected new agents to reduce glycemia. Summary As diabetic dyslipidemia plays a key role in CVD, aggressive treatment is indicated. New research targets include apo-CIII and lipoprotein(a) [Lp(a)]. In addition, new antihyperglycemic therapy is changing diabetes care and altering treatment guidelines. The most recent American Diabetes Association Standards of Care has expanded its recommendations for people with CVD and diabetes, suggesting that medications validated to improve cardiac health should be strongly considered.

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Section: Diabetic Dyslipidemiamentioning

confidence: 99%

“…There are several risk factors apart from hyper-glycemia that contribute to the high prevalence of CVD seen in patients with diabetes, with one of the most important being diabetic dyslipidemia [1,2]. …”

Section: Introductionmentioning

confidence: 99%

Towards more specific treatment for diabetic dyslipidemia

Rodríguez

Newman

Schwartzbard

2018

Current Opinion in Lipidology

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“…In type 2 diabetes mellitus, the classic diabetic dyslipidemia characterized by elevated fasting TG levels and lower HDL-C (16) also includes postprandial hyperlipidemia (17,18). Patients with Familial Combined Hyperlipidemia (FCH) show changing lipoprotein phenotypes with sometimes increased LDL-C and/or TGs.…”

Section: Hypertriglyceridemia Remnant Cholesterol and Postprandial Hmentioning

confidence: 99%

Is it time to break the fast?—a paradigm shift in clinical lipidology

2016

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“…In Type 2 diabetic state there has been observed reduced LpL activity in post heparin blood thus initiating diabetic hyperlipidemia [18]. Also, hormonesensitive lipase (HSSL) which is an enzyme responsible for the conversion of triglyceride into fatty acids and monoglyceride is activated by insuin, hence, in a state of insulin deficiency or insulin resistance there is inhibition of the enzyme action which may culminate into hypertriglyceridemia in diabetic state [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Raw and Cooked Ginger (<i>Zingiber officinale</i> Roscoe) Extracts on Serum Cholesterol and Triglyceride in Normal and Diabetic Rats

Paulina¹,

Rasaki²,

Veronica³

2018

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Dyslipidemia is a risk factor of concern in public health even in a state of anomaly in blood glucose level. The effect of different ginger extracts on body lipids has been reported, few scientific studies have documented the effect of raw ginger extracts while the effect of cooked ginger extract (the form in which the spice is commonly consumed) is yet to be explored. This experimental study was therefore designed to determine the effect of raw and cooked ginger extracts on serum triglycerides and total cholesterol in diabetic rats and compare this with that of non-diabetic rats. Fresh ginger rhizomes were washed peeled, washed, wet-milled (without addition of water) and sieved to give the raw extract. A portion of of the extract was boiled for one hour and cooled to give cooked ginger extract. Seventy male albino rats of weight range 155g-195g were divided into 7 groups (n=10) with 3 groups kept as normal or non-diabetic while the remaining 4 groups were rendered diabetic by intraperitoneal administration of 60mg/kg body weight of streptozocin (STZ) to mimic Type 1 diabetes mellitus. These were repeated with another set of seventy rats but diabetes was induced in the 4 diabetic groups here with a 12 week consumption of high-fat diet (HFD) to mimic Type 2 diabetes mellitus. Serum total cholesterol and triglyceride were determined before and after diabetes induction as well as at the 2 nd and 4 th weeks of extracts and diabetic drugs administration using standard methods. Mean data were compared using Least Significant Difference at p≤0.05.Raw and cooked ginger extracts significantly reduced serum total cholesterol and triglyceride in both medium (2 weeks) and long (4 weeks) terms administration in non diabetic rats. In STZ-induced diabetic rats only raw ginger extract lowered these parameters significantly while the cooked extracts and glybenclamide increased these significantly. However, in HFD-induced diabetic rats, raw, cooked ginger extracts and Metformin reduced both serum total cholesterol and triglyceride significantly. Ginger in both raw and cooked forms may therefore be useful in ameliorating hyperlipidemia which commonly associates diabetic state. Human trial is hereby recommended.

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Diabetes Dyslipidemia

Cited by 340 publications

References 136 publications

Towards more specific treatment for diabetic dyslipidemia

Towards more specific treatment for diabetic dyslipidemia

Is it time to break the fast?—a paradigm shift in clinical lipidology

Effect of Raw and Cooked Ginger (<i>Zingiber officinale</i> Roscoe) Extracts on Serum Cholesterol and Triglyceride in Normal and Diabetic Rats

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