Diabetes insipidus associated with an empty sella turcica

Abstract

Summary A patient with severe diabetes insipidus for 14 years was found to have an enlarged and eroded sella turcica with greatly reduced pituitary tissue on pneumo-encephalography. It is suggested that the permanent diabetes insipidus may have resulted from growth of an intrasellar tumour, which subsequently infarcted spontaneously. Thyroid and pituitary-adrenal function nevertheless remained good, which accounts for persistence of the diabetes insipidus.

Hajdu-Cheney Syndrome Associated with Intrauterine Fractures and Arachnoid Cysts

“…The exact aetiology and pathogenesis of this syndrome is still unknown. Twenty-seven cases have been reported and amongst these there have been 4 families with autosomal dominant inheritance (Coigne et al 1978, Cheney 1965, Elias et al 1978, Matisonn & Ziady 1973. However, the majority of cases have been sporadic.…”

Symptomatic hypopituitarism revealing a primary empty sella turcica

“…Diabetes insipidus associated with primary empty sella syndrome was reported in 4 cases (Schaison and Metzger, 1969;Cupps and Wolff, 1978;Marisson and Pimstone, 1973). Two cases with gonadotropic insufficiency (Neelon et al, 1973;Bernasconi, Giovanelli and Papo, 1972) myxoedema (Neelon et al, 1973;Cupps and Woolf, 1978), one patient was admitted with generalized weakness and loss of appetite (Mortara and Norrell, 1970), and two subjects had a picture of panhypopituitarism (without further details), secondary to meningo-encephalitis and cranial trauma respectively (Schaison and Metzger, 1969).…”

Diabetes insipidus in preleukaemic phase of acute myeloid leukaemia in 2 patients with empty della turcica: A report of 2 cases

“…In the empty sella turcica, minor changes in the hypophyseal function can be found (9) but diabetes insipidus has rarely been reported in association with empty sella turcica (10). Diabetes insipidus may be caused by a defect in the hypothalamus or neurohypophysis.…”