2012
DOI: 10.4239/wjd.v3.i4.60
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Diabetes, insulin and cancer risk

Abstract: There is a consensus that both type 1 and type 2 diabetes are associated with a spectrum of cancers but the underlying mechanisms are largely unknown. On the other hand, there are ongoing debates about the risk association of insulin use with cancer. We have briefly reviewed recent related research on exploration of risk factors for cancer and pharmacoepidemiological investigations into drug use in diabetes on the risk of cancer, as well as the current understanding of metabolic pathways implicated in intermed… Show more

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Cited by 14 publications
(10 citation statements)
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“…Insulin is a hormone that has an important role in glucose homeostasis in a dynamic relationship with both feeding and fasting as well as in growth and development of body tissues [61,62]. Insulin is mainly synthesized by pancreatic β-cells and secreted to peripheral circulatory system.…”
Section: Impaired Insulin and Glucose Metabolism In Ad And Diabetesmentioning
confidence: 99%
“…Insulin is a hormone that has an important role in glucose homeostasis in a dynamic relationship with both feeding and fasting as well as in growth and development of body tissues [61,62]. Insulin is mainly synthesized by pancreatic β-cells and secreted to peripheral circulatory system.…”
Section: Impaired Insulin and Glucose Metabolism In Ad And Diabetesmentioning
confidence: 99%
“…Intriguingly, data from a previous study have shown that insulin is a proliferation factor for prostate cancer; thus, the reduction of carbohydrates may subsequently decrease serum insulin and slow down prostate cancer proliferation [ 208 ]. Epidemiological studies have shown that patients with type 2 diabetes and obesity have a greater likelihood of having liver, colorectal, breast, and pancreatic cancers [ 209 , 210 ]. These findings suggest that leptin [ 203 , 211 ], insulin/insulin-like growth factor-1 [ 212 , 213 ], adiponectin [ 203 , 211 ], and inflammation [ 214 , 215 ] are additive between type 2 diabetes or obesity and cancers.…”
Section: Molecular Connectivity Of Oxidative Stress-induced Diseasmentioning
confidence: 99%
“…Another hypothesis suggests that hyperglycaemia may play a role, whereby cancer growth could be delayed among those with well-controlled diabetes and preclinical cancer. [ 30 ] Thirdly, it has not been studied whether insulin therapy could negatively affect anti-cancer treatment thereby increasing mortality. We also analysed cancer mortality by censoring the first 12 months of insulin use ( S1 Table , Model 10).…”
Section: Discussionmentioning
confidence: 99%