Diabetes is associated with increased risk of venous thromboembolism: A systematic review and meta-analysis

Bai, Jing; Ding, Xiang; Du, Xiaohui; Zhao, Xiaohong; Wang, Zhiquan; Ma, Zhiqiang

doi:10.1016/j.thromres.2014.11.003

Cited by 61 publications

(60 citation statements)

References 35 publications

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“…Of these publications, eight publications met the inclusion criteria[4,5,27–32] (See supplemental Figure S1 for flow diagram and supplemental Table S1 for exclusion log). We further identified 8 publications[3,6,7,33–37] through manual review of reference lists of eligible articles and review articles[1,2,38–42]. Additionally, we obtained previously unpublished results from 3 studies through querying experts (queried A.R.F.…”

Section: 3 Resultsmentioning

confidence: 99%

“…Both estimated a 1.4-fold increased risk of VTE for persons with diabetes compared to persons without[1,2]. However, the 2008 meta-analysis[1] did not account for age, BMI, or race as potential confounding variables to the diabetes-VTE relation, making results difficult to interpret.…”

Section: 4 Discussionmentioning

confidence: 99%

“…However, reported associations of DM with VTE are inconsistent, and many estimates from previous studies have not accounted for the potential confounding effect of obesity. Two previous systematic reviews each estimated a 1.4-fold increased risk of VTE for persons with DM compared to persons without[1,2]. However, neither analysis adequately accounted for potential confounders of the DM-VTE association, making it difficult to know whether the observed increased risk in VTE is due to other VTE risk factors associated with DM.…”

Section: 1 Introductionmentioning

confidence: 99%

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Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis

Bell

Folsom

Lutsey

et al. 2016

Diabetes Research and Clinical Practice

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Diabetes mellitus (DM) may be a risk factor for venous thromboembolism (VTE) but results are inconsistent. Aim We conducted a systematic review and meta-analysis of epidemiologic studies to quantify the association between DM and VTE. Methods and results We included studies identified in PubMed, Web of Science, and CINAHL through 07/31/2014. We identified 19 studies that met our selection criteria. We pooled RRs using a random-effects model: the pooled RR for the association of DM with VTE was 1.10 (95% CI: 0.94–1.29). Between-study heterogeneity was explored with a forest plot, funnel plot, meta-regression, and a stratified analysis. Between-study heterogeneity was observed and not explained by study design, method of DM assessment, or degree of adjustment for confounding. Sensitivity analyses omitted one study at a time to assess the influence of any single study on the pooled estimate. These analyses indicated that one large study was highly influential; when this study was excluded, the pooled estimate increased and just reached statistical significance: 1.16 (95% CI: 1.01–1.34)]. Conclusions This meta-analysis suggests either no association or a modest positive one between DM and VTE in the general population. DM is unlikely to play a major role in VTE development.

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Section: 3 Resultsmentioning

confidence: 99%

Section: 4 Discussionmentioning

confidence: 99%

Section: 1 Introductionmentioning

confidence: 99%

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Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis

Bell

Folsom

Lutsey

et al. 2016

Diabetes Research and Clinical Practice

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“…179 Diabetes mellitus was reported to augment the risk of recurrent VTE in younger patients in the Worcester Venous Thromboembolism Study of 2488 consecutive patients with validated VTE. 180 In a meta-analysis of >803 million participants, including 10.5 million patients with VTE, 181 diabetes mellitus increased the risk of first VTE by 35% and first and recurrent events by 50%.…”

Section: Venous Thromboembolismmentioning

confidence: 99%

Vascular Complications of Diabetes

Beckman

Creager

2016

Circulation Research

299

218

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Over the last several decades, the global incidence and prevalence of diabetes mellitus has increased significantly. The raised incidence rate is projected to continue as greater numbers of persons adopt a Western lifestyle and diet. Patients with diabetes mellitus are at heightened risk of both adverse microvascular and cardiovascular events. Moreover, once cardiovascular disease develops, diabetes mellitus exacerbates progression and worsens outcomes. The medical management of patients with diabetes mellitus mandates comprehensive risk factor modification and antiplatelet therapy. Recent clinical trials of new medical therapies continue to inform the care of patients with diabetes mellitus to reduce both cardiovascular morbidity and mortality.

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“…The logistic regression also suggested that T2DM increased the Khorana VTE risk by 1.499 fold. Several meta-analyses have documented that diabetes is associated with increased risk of VTE (21,22). This association may be caused by factors such as hyperglycemia, hyperinsulinemia, inflammation, and shared factors such as age, obesity, dyslipidemia, etc.…”

Section: Discussionmentioning

confidence: 99%

Influence of type 2 diabetes mellitus on Khorana venous thromboembolism risk in colorectal cancer patients

Wang

Zhao

et al. 2017

Rev Esp Enferm Dig

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Background: Many studies have documented the association between venous thromboembolism (VTE) and colorectal cancer (CRC). The Khorana model is a VTE risk assessment model for predicting cancer-associated thrombosis. Type 2 diabetes (T2DM) has also been reported to increase the risk of VTE.Purpose: The aim of this study was to investigate the influence of T2DM on Khorana VTE risk in CRC patients and to explore the relationship between Khorana VTE category and CRC clinicopathological factors.Methods: This analysis included 615 CRC patients (205 with T2DM). Fibrinogen and D-dimer levels were compared within each group. A comparison was made of the proportion of patients in different Khorana VTE risk categories in CRC patients with and without T2DM. The association between Khorana VTE risk category and clinicopathological factors among all the CRC patients was evaluated.Results: Fibrinogen levels of CRC patients with T2DM were significantly higher than those of non-diabetes patients (4.13 ± 1.06 vs 3.94 ± 0.98, p < 0.001

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Diabetes is associated with increased risk of venous thromboembolism: A systematic review and meta-analysis

Cited by 61 publications

References 35 publications

Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis

Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis

Vascular Complications of Diabetes

Influence of type 2 diabetes mellitus on Khorana venous thromboembolism risk in colorectal cancer patients

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