Diabetes Is Associated with Musculoskeletal Pain, Osteoarthritis, Osteoporosis, and Rheumatoid Arthritis

Abstract

Aim To investigate the associations between diabetes and musculoskeletal pain, osteoarthritis, osteoporosis, and rheumatoid arthritis. Methods Self-reported data were provided by the nationwide Danish National Health Survey 2013. Inclusion criteria were age ≥ 40 years and known diabetes status. The exposure variable was diabetes, and the outcome variables included musculoskeletal pain during the last 14 days in three body sites (back/lower back, limbs, and shoulder/neck), osteoarthritis, osteoporosis, and rheumatoid arthritis. Logistic regression analyses adjusted for age, gender, BMI, education, marital status, and physical activity were performed. Results 9,238 participants with diabetes were 65.6 ± 11.0 (mean ± SD) years old; 55.6% were males. 99,980 participants without diabetes were 59.2 ± 11.8 years old; 46.7% were males. Diabetes was associated with back/lower back pain (OR 1.2 (CI 95% 1.1-1.2), p < 0.001), pain in the limbs (1.4 (1.3-1.4), p < 0.001), shoulder/neck pain (1.2 (1.1-1.3), p < 0.001), osteoarthritis (1.3 (1.2-1.4), p < 0.001), osteoporosis (1.2 (1.1-1.4), p = 0.010), and rheumatoid arthritis (1.6 (1.4-1.7), p < 0.001). In participants with diabetes, physical activity was associated with reduced pain (e.g., back/lower back pain (0.7 (0.6-0.7), p < 0.001)). Conclusion Diabetes was associated with elevated odds of having musculoskeletal pain. Diabetes was also associated with elevated odds of having osteoarthritis, osteoporosis, and rheumatoid arthritis. The most frequent disease in individuals with diabetes was osteoarthritis. The reported pain may have negative impacts on the level of physical activity. Health-care professionals should remember to inform patients with diabetes that musculoskeletal pain, osteoarthritis, osteoporosis, and rheumatoid arthritis are not contraindications to exercise training.

Is There an Association between Diabetes and Neck and Back Pain? Results of a Case-Control Study

“…The association between diabetes and spinal musculoskeletal pain, i.e., CLBP or CNP, is in agreement with previous reports [ 9 , 10 , 11 , 16 , 17 ]. The magnitude of the association with diabetes was slightly greater for CNP (OR: 1.34) than the magnitude observed for CLBP (OR: 1.19).…”

“…Additionally, the co-existence of these conditions was also associated with lower practice of physical activity and worse self-rated health perception. A negative impact of these conditions in physical activity, health-perception and quality of life has already been reported [ 9 , 16 , 36 ]. Therefore, it would be reasonable to suggest that direct and indirect burden related to diabetes will be higher if it is associated with CNP or CLBP.…”

“…The challenge to the health system and health care providers is not the only the diabetes itself but also its related complications and comorbidities [ 5 , 6 , 7 , 8 ]. Chronic musculoskeletal pain is a frequent comorbid condition of diabetes [ 9 , 10 , 11 ]. Similar to diabetes, low back and neck pain also represent prevalent and disabling conditions which have shown a 19% increase in rate of prevalence and years living with disability from 2005 to 2015 [ 12 ].…”

“…Even if several previous studies have researched diabetes and spinal pain the differences in methodologies and settings (health centers or population based), variables collected, small sample sizes and statistical methods make comparisons difficult and conclusions dubious [ 9 , 10 , 11 , 13 , 15 , 16 , 17 , 18 ].…”

Маркери Обміну Сполучної Тканини У Хворих З Діабетичними Артропатіями

“…В загальній популяції дегенеративно-дистрофічні ураження суглобів переважно розвиваються у хворих старших за 60 років. Проте на тлі ЦД зміни в суглобах розвиваються значно раніше і можуть діагностуватись навіть у молодих людей [2,3]. ДА представляють собою дегенеративний процес, що залучає хрящ, синовівальну мембрану та субхондральну кістку і розвивається на тлі тривалих метаболічних порушень та дисбалансу процесів біомеханічного стресу.…”