Diabetes Mellitus and Cardiogenic Shock Complicating Acute Myocardial Infarction

Echouffo‐Tcheugui, Justin B.; Kolte, Dhaval; Khera, Sahil; Aronow, Herbert D.; Abbott, J. Dawn; Bhatt, Deepak L.; Fonarow, Gregg C.

doi:10.1016/j.amjmed.2018.03.004

Cited by 26 publications

(23 citation statements)

References 32 publications

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“…This rate is similar to or lower than previous cohorts including AMI and CS patients (range 17-43%). 5,6,[21][22][23] The results of the present study are consistent with a large registry-based study from 2018 including 1,332,530 patients with AMI, of which 72,765 were complicated by CS. The study showed that patients with AMI and DM were more likely to develop CS and that AMICS patients with DM had an increased risk of mortality after adjusting for comorbidity and cardiovascular risk factors.…”

Section: Discussionsupporting

confidence: 88%

“…The study showed that patients with AMI and DM were more likely to develop CS and that AMICS patients with DM had an increased risk of mortality after adjusting for comorbidity and cardiovascular risk factors. 6 Our findings demonstrate a more significant association between DM and 30-day mortality than reports from the Shock Trial Registry and PL-ASC registry in the setting of CS. These reports showed a weakened and only borderline significant association between DM and short-term mortality after adjusting for the worse cardiovascular profile of DM patients.…”

Section: Discussioncontrasting

confidence: 45%

“…1,2,4 Recent data suggest that patients' clinical presentations have changed over the past decade and that contemporary AMICS patients may present with more compromised haemodynamics. 4 Patients with AMI with concomitant diabetes mellitus (DM) have an increased risk of developing CS 5,6 and there is evidence that the incidence of CS following AMI is increasing at the population level. 4 However, the association between DM and mortality in AMICS patients is studied to a lesser extent and, therefore, seems relevant to investigate.…”

Section: Introductionmentioning

confidence: 99%

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The association of diabetes and admission blood glucose with 30-day mortality in patients with acute myocardial infarction complicated by cardiogenic shock

Thoegersen

Josiassen

Helgestad

et al. 2020

European Heart Journal. Acute Cardiovascular Care

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Background Cardiogenic shock is the leading cause of death in patients with acute myocardial infarction, with short-term mortality of approximately 50%. Whether diabetes mellitus and high blood glucose levels are associated with mortality in contemporary patients with acute myocardial infarction complicated by cardiogenic shock is inadequately described. Purpose To investigate if diabetes mellitus and high admission blood glucose were associated with 30-day mortality in a large, contemporary population with acute myocardial infarction complicated by cardiogenic shock. Methods Patients with acute myocardial infarction complicated by cardiogenic shock admitted at two tertiary centres in Denmark from 2010 to 2017 were individually identified through patient charts, resulting in the inclusion of 1716 cardiogenic shock patients. Glucose level at admission to the intensive care unit was available in 1302 patients. Results There was no significant difference in 30-day mortality between diabetes mellitus types I and II (63% vs. 62%, NS). Thirty-day mortality was significantly higher in diabetes patients compared to non-diabetes patients (62% vs. 50%, P < 0.001). Increasing admission glucose was associated with increasing 30-day mortality in a dose-dependent manner in diabetes mellitus (4–8 mmol/L, 41%; 8–12 mmol/L, 49%; 12–16 mmol/L, 63%; >16 mmol/L, 67%; P = 0.028) and non-diabetes patients (4–8 mmol/L, 32%; 8–12 mmol/L, 43%; 12–16 mmol/L, 57%; >16 mmol/l; 68%; P < 0.001). Conclusion Patients with acute myocardial infarction complicated by cardiogenic shock and concomitant diabetes mellitus type I or II had a significantly higher 30-day mortality in comparison to patients without diabetes mellitus, whereas no difference was found between diabetes mellitus types I and II. High glucose levels on admission to the intensive care unit were associated with increased 30-day mortality in diabetes mellitus and non-diabetes mellitus patients.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association of diabetes and admission blood glucose with 30-day mortality in patients with acute myocardial infarction complicated by cardiogenic shock

Thoegersen

Josiassen

Helgestad

et al. 2020

European Heart Journal. Acute Cardiovascular Care

View full text Add to dashboard Cite

show abstract

“…Thus, diabetes is not just a health crisis, but a global disaster [1]. Diabetes itself is dangerous and unless adequate treatment is provided, diverse and serious complications such as diabetic retinopathy [2], stroke [3], chronic renal failure [4], angina pectoris [5], and myocardial infarction [6] can cause a decrease in quality of life and lead to patient death.…”

Section: Introductionmentioning

confidence: 99%

Natural Magnesium-Enriched Deep-Sea Water Improves Insulin Resistance and the Lipid Profile of Prediabetic Adults: A Randomized, Double-Blinded Crossover Trial

Shon

2020

Nutrients

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Previous in vitro and in vivo studies have shown that the antidiabetic effect of balanced deep-sea water (BDSW) works through the suppression of hyperglycemia and improvement of glucose tolerance. Based on these promising results, we conducted an eight week randomized, double-blinded crossover trial of the effects of BDSW in prediabetic adults. The subjects consumed 440 mL of BDSW (hardness 4000) per day, and maintained an otherwise normal lifestyle and diet throughout. Efficacy assessments were made by measuring fasting glucose, postprandial glucose, fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), C-peptide, glycosylated hemoglobin, lipid metabolism indicators, and physical metrics, along with safety assessments. Fasting insulin and HOMA-IR values of the BDSW group were significantly lower than those of the placebo group after eight weeks of BDSW ingestion. Total cholesterol and low-density lipoprotein–cholesterol were also significantly decreased in the BDSW group after eight weeks of BDSW ingestion compared with the placebo group. There were no statistically and clinically meaningful changes in adverse events, physical examination, laboratory medicine examination, or vital signs of the BDSW intake group. These results suggested that the intake of BDSW in prediabetic adults can improve glucose metabolism and lipid profiles and is safe for human consumption.

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“… 1 The threats are even much greater to diabetes mellitus (DM) patients, who, compared with non-DM patients, have shown significant worse prognosis and a higher death rate from AMI. 2 , 3 The accumulation of hepatocyte growth factor (HGF) in ischemic myocardium has been observed in both processes of experimental ischemia and reperfusion (I/R) and permanent coronary artery occlusion. According to the study of Nakamuraand Mizuno, 4 HGF plays an essential role in the post-myocardial infarction (MI) self-repair.…”

Section: Introductionmentioning

confidence: 99%

Hepatocyte growth factor intervention to reduce myocardial injury and improve cardiac function on diabetic myocardial infarction rats

et al. 2020

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Acute myocardial infarction (AMI) is recognized to be a severe threat to people’s health conditions and life quality. The accumulation of hepatocyte growth factor (HGF) in ischemic myocardium has been observed in both processes of experimental ischemia and reperfusion (I/R) and permanent coronary artery occlusion. The aim of the study was to investigate the effect of HGF on myocardial cell apoptosis, ventricular remodeling and cardiac function after myocardial infarction (MI) in diabetic rats, and to explore whether the effect is mediated by HGF/c-Met signaling pathway. MI significantly increases LVWI and RVWI and myocardial apoptotic index, and up-regulates the expression of HGF and c-Met at mRNA and protein levels in MI control group. The LVWI and RVWI, and myocardial apoptosis were reduced by treatment with HGF, which also increased the myocardial cell viability and the expression of HGF and c-Met. In summary, HGF significantly attenuates myocardial apoptosis and improves cardiac function after AMI in diabetic rats by further enhancing the activation of HGF/c-Met pathway.

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Diabetes Mellitus and Cardiogenic Shock Complicating Acute Myocardial Infarction

Cited by 26 publications

References 32 publications

The association of diabetes and admission blood glucose with 30-day mortality in patients with acute myocardial infarction complicated by cardiogenic shock

The association of diabetes and admission blood glucose with 30-day mortality in patients with acute myocardial infarction complicated by cardiogenic shock

Natural Magnesium-Enriched Deep-Sea Water Improves Insulin Resistance and the Lipid Profile of Prediabetic Adults: A Randomized, Double-Blinded Crossover Trial

Hepatocyte growth factor intervention to reduce myocardial injury and improve cardiac function on diabetic myocardial infarction rats

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