Diabetes Mellitus and Chronic Obstructive Pulmonary Disease: An Overview

Abstract

Chronic obstructive pulmonary disease (COPD) is a common disease with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Apart from cigarette smoking, certain occupational and environmental exposures, low socioeconomic status and genetic factors may contribute to the pathogenesis of COPD. Comorbidities, e. g. diabetes mellitus (DM), can negatively affect quality of life, COPD outcomes and cardiovascular risk. The present narrative review considers the potential links between COPD and DM, such as systemic inflammation, oxidative stress, hypoxaemia and hyperglycaemia. The effects of antidiabetic drugs on lung function and COPD outcomes, as well as the possibility of common therapeutic modalities are also briefly considered. Further research is needed in this field to elucidate these relationships as well as their potential clinical implications in daily practice.

The Role of MDR1 (C3435T) Gene Polymorphism in Patients with Chronic Obstructive Pulmonary Disease Associated with Type 2 Diabetes Mellitus

“…The development of chronic systemic inflammation is found to be the characteristic of COPD and the appearance of systemic effects [ 11 ], leading to an increased incidence of concomitant pathology [ 12 , 13 ]. The incidence of type 2 diabetes mellitus (DM) with COPD is proved to be higher than in the case of its absence [ 14 - 16 ]. The role of the MDR1 gene (C3435T) polymorphism in the development and advance of COPD [ 17 - 19 ] has been studied, although the results of these studies are controversial.…”

The role of counterinsular hormones in the regulation of glucose homeostasis and the pathogenesis of type 2 diabetes mellitus in COPD

“…Понимание сути их частого совместного протекания важно для совершенствования и разработки новых методов диагностики и терапевтических подходов к этим заболеваниям [ 18 ]. В частности, СД2 может негативно влиять на качество жизни и исходы ХОБЛ, учитывая наличие потенциальных общих связей между ними, таких как системное воспаление, окислительный стресс, гипоксемия и гипергликемия [ 19 ]. На выраженную негативную роль коморбидности ХОБЛ и СД2 указывают исследования Ho T.W.…”

Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat) Deposition in Chronic Obstructive Pulmonary Disease: An Overview

“…It has been hypothesized that COPD may contribute to NAFPD development through systemic and local inflammation, excessive lipolysis and increased lipid synthesis, as well as intermittent hypoxia-induced pancreatic beta cell damage, thus representing potential mechanisms linking COPD with NAFPD [111]. Insulin resistance has also been related to COPD [112,113], as well as to NAFPD [114]. However, no data exist on peripancreatic adipose tissue in relation to COPD.…”