Diabetes mellitus and congestive heart failure: the prevalence of congestive heart failure in patients with and without diabetes in Poland

Wierzba, Waldemar; Karnafel, Waldemar; Śliwczyński, Andrzej; Pinkas, Jarosław; Gujski, Mariusz

doi:10.5114/aoms.2018.74261

Cited by 3 publications

(1 citation statement)

References 107 publications

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“…Prediabetes is an intermediate stage between normoglycemia and overt T2D and is associated witholder age and obesity [10] . Even though that prediabetes is asymptomatic, subjects with pre-diabetes are at risk of progression to T2D, as well as cardiovascular disease [11] [12] .…”

Section: Introductionmentioning

confidence: 99%

Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation

Klisić¹

2023

J Med Biochemistry

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Objective: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) and overt type 2 diabetes (T2D) using principal component analysis (PCA) as a thorough statistical approach. Patients and Methods: Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and fibrinogen) and oxidative stress markers [pro-oxidants (AOPP, PAB, TOS) and antioxidants (PON1, tSHG, TAS)] were measured. PCA was applied to explore the factors most strongly influencing glucoregulation. Results: A total of 278 subjects were enrolled: 37 PRE, 42 NT2D and 99 T2D, who were compared with 100 healthy subjects as a control group (CG). PCA emphasized 4 different factors explaining 49% of the variance of the tested parameters: Oxidative stress-Dyslipidemia related factor (with positive loading of TG and tSHG, and with negative loading of HDL-c and TAS), Dyslipidemia related factor (i.e., total cholesterol and LDL-c, both with positive loading), Anthropometric related factor (i.e., waist and hip circumference, both with positive loading) and Oxidative stress-Inflammation related factor (i.e., PAB, fibrinogen, and CRP, all with positive loading). Out of these 4 factors, only Oxidative stress – Dyslipidemia related factor showed a significant predictive capability towards poor glucoregulation. An increase in this factor by one unit showed a 1.6 times higher probability for poor glucoregulation. Conclusion: Redox disbalance (determined with lower TAS and higher tSHG), in addition to higher TG and lower HDL-c were associated with poor glucoregulation.

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Section: Introductionmentioning

confidence: 99%

Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation

Klisić¹

2023

J Med Biochemistry

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Sodium-glucose co-transporter-2 inhibitors and epicardial adiposity

Yaribeygi

Maleki

Butler

et al. 2023

European Journal of Pharmaceutical Sciences

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Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure

Liu,

et al. 2024

Arch Med Sci

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IntroductionWe aimed to explore the prognostic value of the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio in non-surgical patients with type 2 diabetes hospitalized for heart failure.Material and methodsUsing a large electronic medical record-based cohort of diabetes in China (WECODe), we gathered data on non-surgical hospitalized patients with type 2 diabetes and heart failure from 2011 to 2019. Baseline AST/ALT ratio was calculated. The primary outcomes were all-cause death within 30 days after discharge, composite cardiac events, major acute kidney injury, and major systemic infection. A multivariable Cox proportional regression model was utilized to evaluate the association between the AST/ALT ratio and outcomes.ResultsThis retrospective cohort included 8,073 patients (39.4% women) with type 2 diabetes hospitalized for heart failure. The median age was 71 years. Higher AST/ALT ratio was associated with higher risks of poor endpoints (with per standard deviation increment in AST/ALT ratio, for death within 30 days after discharge: adjusted hazard ratio [HR], 1.35, 95% confidence interval [CI], 1.21 to 1.50; for composite cardiac events: HR, 1.18, 95% CI: 1.06 to 1.31). Compared to patients in the lowest quartile for the AST/ALT ratio, those in the highest quartile have elevated risk of death within 30 days after discharge and major systemic infection (HRs [95% CIs]: 1.61 [1.18 to 2.19] and 1.28 [1.06 to 1.56], respectively). Subgroup analyses and sensitivity analyses confirmed the robustness of the findings.ConclusionsType 2 diabetes patients hospitalized for heart failure with the AST/ALT ratio in the highest quartile face a poor short-term prognosis.

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Diabetes mellitus and congestive heart failure: the prevalence of congestive heart failure in patients with and without diabetes in Poland

Cited by 3 publications

References 107 publications

Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation

Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation

Sodium-glucose co-transporter-2 inhibitors and epicardial adiposity

Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure

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