Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer

Eibl, Guido; Cruz‐Monserrate, Zobeida; Korc, Murray; Petrov, Maxim S.; Goodarzi, Mark O.; Fisher, William E.; Habtezion, Aida; Lugea, Aurelia; Pandol, Stephen J.; Hart, Phil A.; Andersen, Dana K.

doi:10.1016/j.jand.2017.07.005

Cited by 110 publications

(79 citation statements)

References 185 publications

(162 reference statements)

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“…Obesity has been strongly associated with precancerous lesions and conditions such as colon adenomas [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86], monoclonal gammopathy [87][88][89][90][91][92][93][94][95][96][97][98], chronic pancreatitis [99][100][101][102], or inflammatory bowel disease (IBD) [103][104][105][106]. Observed risks of cancers associated with obesity include breast [107][108][109][110][111], colorectal [112][113][114][115], pancreatic [99]…”

Section: Morbid Obesitymentioning

confidence: 99%

Microbiome and morbid obesity increase pathogenic stimulus diversity

Brücher

Jamall

2019

4open

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The microbiome, the relationship between environmental factors, a high-fat diet, morbid obesity, and host response have been associated with cancer, only a small fraction of which (<10%) are genetically triggered. This nongenetic association is underpinned by a worldwide increase in morbid obesity, which is associated with both insulin resistance and chronic inflammation. The connection of the microbiome and morbid obesity is reinforced by an approximate shift of about 47% in the estimated total number of bacteria and an increase from 38,000,000,000,000 in a reference man to 56,000,000,000,000 in morbid obesity leading to a disruption of the microbial ecology within the gut. Humans contain 6,000,000,000 microbes and more than 90% of the cells of the human body are microorganisms. Changes in the microflora of the gut are associated with the polarization of ion channels by butyrate, thereby influencing cell growth. The decrease in the relative proportion of Bacteroidetes together with a change in the fermentation of carbohydrates by bacteria is observed in morbid obesity. The disruption of homeostasis of the microflora in the obese changes signaling and crosstalk of several pathways, resulting in inflammation while suppressing apoptosis. The interactions between the microbiome and morbid obesity are important to understand signaling and crosstalk in the context of the progression of the six-step sequence of carcinogenesis. This disruption of homeostasis increases remodeling of the extracellular matrix and fibrosis followed by the none-resolvable precancerous niche as the internal pathogenic stimuli continue. The chronic stress explains why under such circumstances there is a greater proclivity for normal cells to undergo the transition to cancer cells.

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Section: Morbid Obesitymentioning

confidence: 99%

Microbiome and morbid obesity increase pathogenic stimulus diversity

Brücher

Jamall

2019

4open

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“…Masalah kesehatan yang saat ini sedang terjadi yaitu double burden disease dimana terdapat peningkatan kejadian penyakit tidak menular/ degenerative yang diikuti dengan peningkatan kejadian penyakit menular. Salah satu penyakit tidak menular yang saat ini mengancam keberlangsungan hidup manusia yaitu diabetes mellitus (Notoatmodjo, 2003(Notoatmodjo, , 2007 (Alzaman and Ali, 2016;Başkan and Tan, 2017;Eibl et al, 2017) Jurnal Manajemen Informasi Kesehatan Indonesia Vol. 7 No.1 Maret 2019ISSN: 23372337-585X (Printed); DOI : 10.33560/jmiki.v7i1.216 Hasil uji statistik pada tabel 2 diketahui bahwa ratarata LOS pasien diabetes mellitus yang PJK lebih tinggi yaitu 11.26 hari dengan variasi 7.64 hari, dibandingkan dengan LOS pasien diabetes mellitus tidak PJK yaitu 9.80 hari dengan variasi 7.77 hari.…”

Section: Hasil Dan Pembahasanunclassified

Perbedaan Length of Stay (LOS) Pasien Diabetes Mellitus Berdasarkan Komplikasi Di RSUP Dr. Sardjito Yogyakarta

Salim¹,

Lubis²,

Sugeng

2019

JurnalMIKI

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Complications are the factors that determine the length of the day of treatment of diabetes mellitus patients in the hospital such as hypertension, stroke, coronary heart disease, cholesterol, obesity and others. This study aims to analyze differences in Length of Stay (LOS) of patients with diabetes mellitus based on complications in RSUP Dr. Sardjito Yogyakarta.This research is an analytic observational quantitative research with cross sectional design. The population is all people with diabetes mellitus from year 2011-2016 recorded in electronic medical record. All the population used as research sample that is as many as 1,554 people. Independent variables in this study were hypertension, nephropathy, neuropathy, obesity, CHD, stroke, and pulmonary TB. Dependent variable is Length of Stay or long treatment of diabetes mellitus patient. Data analysis was performed using Independent T test. Diabetes mellitus patients at RSUP Dr. Sardjito year 2011-2016 amounted to 1,554 people with a trend that tends to decline. Most patients were aged 56-63 years (27.86%). The incidence of diabetes mellitus is dominated by type 2 with the highest complications being hypertension, nephropathy, and neuropathy. Based on the result of statistical test, there is a significant difference between the average LOS between patients with diabetes mellitus who have hypertension complications with non-hypertensive (p-value = 0.00), neuropathy with non-neuropathy (p-value = 0.00), coronary heart disease with which is not coronary heart disease (p-value = 0.035), and stroke with non-stroke (p-value = 0.032). Conclusions: There is significant difference in mean LOS among patients with diabetes mellitus who have complications of hypertension, neuropathy, coronary heart disease, and stroke with no complications of the disease.

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“…Physical activity was reported as a binary (yes or no) variable based on a questionnaire asking participants whether they engaged in physical activity for at least 30 min per day, on at least 5 days per week. Abdominal obesity was determined as a waist circumference of ≥ 88 cm in women and ≥ 102 cm in men [49]. Waist circumference was measured at the umbilical area, over light clothes.…”

Section: Definitionsmentioning

confidence: 99%

Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis

Gold-Smith

Singh

Petrov

2019

Exp Clin Endocrinol Diabetes

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Aim The study aimed to investigate the associations between glycaemic control after acute pancreatitis and gastrointestinal motility, using plasma motilin concentration and gastroparesis cardinal symptom index score as proxies. Methods This cross-sectional study recruited a total of 93 individuals after acute pancreatitis. Gastroparesis cardinal index scores, demographic and anthropometric factors, as well as pancreatitis-related factors were analysed. Fasting venous blood was collected to measure motilin, glycated haemoglobin, and fasting blood glucose. Linear regression analyses were conducted to investigate the associations between glycaemic control and gastrointestinal motility in unadjusted and adjusted models. Results Motilin was significantly higher in individuals with diabetes across all adjusted models, with the highest ß-coefficient (95% confidence interval) of 588.89 (138.50, 1039.28); P=0.010. Fasting blood glucose was significantly associated with motilin across all models, with the highest ß-coefficient (95% confidence interval) of 156.30 (55.49, 257.10); P=0.002. Glycated haemoglobin was significantly associated with motilin in one adjusted model with ß-coefficient (95% confidence interval) of 18.78 (1.53, 36.02); P=0.033. Gastroparesis cardinal symptom index was not significantly associated with any measure of glycaemic control. Conclusions Diabetes in individuals after acute pancreatitis appears to be characterised by elevated plasma motilin but not gastroparesis cardinal symptom index. The role of motilin in this setting warrants further investigations.

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Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer

Cited by 110 publications

References 185 publications

Microbiome and morbid obesity increase pathogenic stimulus diversity

Microbiome and morbid obesity increase pathogenic stimulus diversity

Perbedaan Length of Stay (LOS) Pasien Diabetes Mellitus Berdasarkan Komplikasi Di RSUP Dr. Sardjito Yogyakarta

Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis

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