Diabetes mellitus and periodontal disease

Metgud, Renuka; Kore, Smita

doi:10.4103/2349-5006.135022

Cited by 5 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 400 mg/kg ethanol extract had the highest percentage reduction in glucose level (53.21%) in 28 days, even more than the standard drug group (24.74 %) while the 200 mg/kg ethanol extract gave the least percentage reduction. These findings were similar to the findings of Metgud and Kore [37] and Ijaola et al [1]; where the potato extracts reduced the glucose levels and may be thought to have normalized albumin, globulin and serum liver enzymes activity, increased the level of high-density lipoproteins and decreased protein glycation levels than the standard drug. Glibenclamide belongs to the class of drugs called sulfonylureas.…”

Section: Sodsupporting

confidence: 90%

“…It has been documented to possess antidiabetic properties as among the Yorubas in the South-West Nigeria, hot water infusion of the plant of Ipomoea batatas continues to be highly valued in the local management of diabetes because of its effectiveness in the control of blood glucose and its low cost [1]. It was also shown by other researchers to decrease blood glucose levels, increase high density lipoproteins and reduces low density lipoproteins levels all due to the presence of dietary fibers with low glycemic index [6,7]. This all-important ethnobotanical value of I. batatas predisposes the plant for a scientific evaluation of its potentials, hence the need to study the antidiabetic activities of the aqueous and ethanol extract of I. batatas tubers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-diabetic Effects of the Aqueous and Ethanol Extracts of Ipomoea batatas Tubers on Alloxan Induced Diabetes in Wistar Albino Rats

Okafor

Ezekwesili

Mbachu

et al. 2021

IJBcRR

View full text Add to dashboard Cite

Background: Diabetes mellitus continues to remain the number one cause of mortality among the low- and mid-income populations. Hence, the need for cost-effective, available and accessible novel drug agents for improved health outcomes. This study was undertaken to investigate the antidiabetic effects of the aqueous and ethanol extracts of Ipomoea batatas tubers on alloxan induced diabetes in Wistar albino rats. Methods: Proximate analysis was conducted directly on the sweet potato tubers using the method of AOAC (2004) while ethanol and aqueous extracts obtained from the Ipomoea batatas tubers were subjected to phytochemical analysis using various standard methods. Seven groups of 5 albino Wistar rats each were used for the study as follows: the negative control group, the standard drug group treated with Glibenclamide, the 200 mg/kg aqueous extract group, the 400 mg/kg aqueous extract group, the 200 mg/kg ethanol extract group, the 400 mg/kg ethanol extract group and the untreated group. The rats were induced to diabetes by administering alloxan (130 mg/kg) intraperitoneally. Further, the extracts were orally administered to the four treatment groups while changes in both weights and blood glucose levels were closely monitored. After 28 days, blood samples were collected and assayed for the activities of superoxide dismutase, glutathione peroxidase and catalase. Data were further subjected to statistical analysis using ANOVA (Analysis of Variance). Results: The proximate analysis of I. batatas showed a high carbohydrate content of 86.37 ± 0.04 while the fat amount was lowest with 0.58 ± 0.18. The phytochemical analysis indicated a high tannin concentration for both aqueous and ethanol extracts at 87.83 ± 2.91 and 89.05 ± 2.53 respectively whereas the lowest content was found for terpernoids in the aqueous extract and total flavonoids in the ethanol extract. Remarkable recovery from weight loss was more rapid in the 400 mg/kg ethanol extract group (29.09% increase) than the other groups. There was no significant difference (P > 0.05) in the initial and final weights of the animals. The difference in final glucose levels were significant (P < 0.05) across treatment groups when compared with the negative control group. The 400 mg/kg ethanol extract had the highest percentage reduction in glucose level (53.21%) in 28 days, even more than the standard drug group (24.74 %). The 200 mg/kg ethanol extract gave the least percentage reduction. The results showed that there was no significant difference (P > 0.05) in the activities of the three antioxidant enzymes across treatment groups. Conclusion: The relatively rapid recovery of weight and reduction in blood glucose levels of the animals observed with the 400 mg/kg ethanol extract showed that it is more potent in the management of diabetes mellitus when compared with the other dosage preparations.

show abstract

Section: Sodsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Anti-diabetic Effects of the Aqueous and Ethanol Extracts of Ipomoea batatas Tubers on Alloxan Induced Diabetes in Wistar Albino Rats

Okafor

Ezekwesili

Mbachu

et al. 2021

IJBcRR

View full text Add to dashboard Cite

show abstract

“…Plant was authenticated and specimen was kept in herbarium of Department of Physiology and Pharmacology, University of Agriculture, Faisalabad. Roots of I. batatas were used to prepare methanolic extract by following Metgud and Kore 10 method. After each extraction, extract was filtered by Whattman filter paper no.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats

Akhtar

Akram

Daniyal

et al. 2018

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Different allopathic drugs are being used for the treatment of diabetes mellitus but more emphasis are being placed on the use of medicinal plants, herbs, and natural extracts of fruits and vegetables due to their easy availability, easy consummation with low cost, and with no well-reported side effects. White skinned sweet potato (WSSP; Ipomoea batatas L.) peel-off was selected to find out its antidiabetic potential as well as to explore the effects on selected biochemical parameters in diabetes-induced Wistar rats. In young (3–4 months) and old (up to 1 year) diabetic Wistar rats, it was found that WSSP (I. batatas L.) peel-off significantly (P < 0.05) decreased blood glucose level, protein glycation level, total cholesterol, triglycerides, and low-density lipoprotein (LDL)-cholesterol. A significant (P < 0.05) increase in high-density lipoprotein (HDL)-cholesterol level after treatment was also reported. Furthermore, it was also found that WSSP peel-off also had beneficial effects on total protein concentration, albumin, globulin, and liver enzymes (serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT)). It might be concluded that antidiabetic potential of WSSP extract is due to the presence of bioactive compounds like glycoprotein, anthocyanins, alkaloids, and flavonoids, which act as insulin-like molecules or insulin secretagogues constituents in sweet potatoes peel-off and these antidiabetic proteins were extracted out in more concentration in methanol due to its organic nature. Further research is needed to purify and quantify the antidiabetic components responsible for antidiabetic effects of WSSP and it should be available in compact dose form for the treatment of diabetic patients.

show abstract

“…Diabetes mellitus (DM) is a group of metabolic disorders characterized by elevated blood glucose levels (hyperglycemia) resulting from defects in insulin secretion, insulin action, or both and leads to long term multiorgan complications. Insulin deficiency in turn leads to chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism 2 . The severe type of hyperglycemia in diabetes mellitus causes abnormality in kidney function, long-term damage, and various major organ failure such as diabetic nephropathy, diabetic neuropathy and diabetic retinopathy 3 .…”

Section: Introductionmentioning

confidence: 99%

To Study the Effect of Zofenopril (Angiotensin Converting Enzyme Inhibitor) in Type 2 Diabetes Induced Nephropathy in Rats

Navis¹,

Kumari²

2015

Int. Res. J. Pharm.

View full text Add to dashboard Cite

The aim of present study was to evaluate the effect of Zofenopril (ACE inhibitor) in type 2 diabetes induced nephropathy in rats. Type 2 diabetes was induced by administering high-fat-diet (HFD) and streptozotocin (35mg/kg; i.p.) single dose. The rats with blood glucose levels more than 250mg/dl were selected as diabetic and taken for further studies. Diabetic rats were treated with two different doses of Zofenopril (1mg/kg and 10 mg/kg/day) p.o. for 21 days while continuing on HFD. Various parameters such as blood glucose, total cholesterol, serum creatinine, urine albumin excretion and markers of oxidative stress such as thiobarbituric acid reactive substance (TBARS) and glutathione (GSH) levels were measured. Treatment of Zofenopril (1mg/kg and 10mg/kg) in diabetic rats orally for 21 days significantly decreased total cholesterol, serum creatinine, and urine albumin levels when compared with diabetic control rats. Treatment of diabetic rats with Zofenopril 1mg/kg and 10mg/kg) orally for 21 days, showed less significant decrease in blood glucose levels when compared to diabetic control rats. Zofenopril treatment also significantly decreased the kidney TBARS levels, while increasing the GSH levels in diabetic rats. These findings suggest that Zofenopril has beneficial effects in preventing the progression of diabetes induced nephropathy in rats. In conclusion, the present study demonstrates that Zofenopril can be used to prevent progression of diabetes induced nephropathy. Administration of Zofenopril improves renal function and ameliorates renal histopathological changes in HFD fed, low dose STZ-induced type 2 diabetic rats; possibly by improvement in lipid metabolism and inhibition of lipid peroxidation process.

show abstract

Diabetes mellitus and periodontal disease

Cited by 5 publications

References 2 publications

Anti-diabetic Effects of the Aqueous and Ethanol Extracts of Ipomoea batatas Tubers on Alloxan Induced Diabetes in Wistar Albino Rats

Anti-diabetic Effects of the Aqueous and Ethanol Extracts of Ipomoea batatas Tubers on Alloxan Induced Diabetes in Wistar Albino Rats

Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats

To Study the Effect of Zofenopril (Angiotensin Converting Enzyme Inhibitor) in Type 2 Diabetes Induced Nephropathy in Rats

Contact Info

Product

Resources

About