Diabetes mellitus and risk of endometrial cancer: a meta-analysis

Abstract

Aims/hypothesis Diabetes has been associated with a statistically significantly increased risk of endometrial cancer in most, but not all studies. To provide a quantitative assessment of the association between diabetes and risk of endometrial cancer, we conducted a meta-analysis of casecontrol studies and cohort studies. Subjects and methods We identified studies by a literature search of PubMed and Embase through to January 2007 and by searching the reference lists of relevant articles. Summary relative risks (RRs) with 95% CIs were calculated using random-effects model. Results The analysis of diabetes (largely type 2) and endometrial cancer is based on 16 studies (three cohort and 13 case-control studies), including 96,003 participants and 7,596 cases of endometrial cancer. Twelve of the studies showed a statistically significantly increased risk and four a non-significant increased risk of endometrial cancer. In our meta-analysis we found that diabetes was statistically significantly associated with an increased risk of endometrial cancer (summary RR 2.10, 95% CI 1.75-2.53). The risk estimates were somewhat stronger among case-control (RR 2.22, 95% CI 1.80-2.74) than among cohort studies (RR 1.62, 95% CI 1.21-2.16), stronger among studies adjusting only for age (RR 2.74, 95% CI 1.87-4.00) compared with multivariate adjustment (RR 1.92, 95% CI 1.58-2.33) and slightly lower in studies performed in the USA than in those performed Europe. The analysis of type 1 diabetes and endometrial cancer was based on three studies and found a statistically significant positive association (summary RR 3.15, 95%CI 1.07-9.29). Conclusions/interpretation Results from the meta-analysis support a relationship between diabetes and increased risk of endometrial cancer.

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

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Should animal fats be back on the table? A critical review of the human health effects of animal fat

“…The effects of high serum glucose and hyperinsulinaemia, hall marks of type 2 diabetes, are well known and are associated with a wide range of chronic diseases of Western civilisation (Kuusisto et al 1997;Xu et al 2004;Friberg et al 2007;Xue and Michels 2007;Johnson et al 2009;Orgel and Mittelman 2013). High serum glucose is functionally related to the glycosylation of protein, which increases the rate of aging of tissues.…”

Diabetes, prediabetes and cancer mortality

“…Epidemiological studies have shown that diabetes [1][2][3][4][5][6][7] or certain treatments for diabetes may increase the risk [8][9][10] of developing cancer. Diabetes may also affect the treatment of cancer; some types of cancer are treated less aggressively in patients with diabetes than in patients without diabetes [11].…”