Diabetes mellitus and the incidence and mortality of colorectal cancer: a meta‐analysis of 24 cohort studies

Abstract

This meta-analysis suggests that individuals with DM have a significant increase in risk of developing CRC.

A Retrospective Study on the Role of Diabetes and Metformin in Colorectal Cancer Disease Survival

“…Although pancreatic cancer was one of the first cancers to be associated with diabetes, diabetes has also since been associated with colorectal cancer, hepatocellular carcinoma, breast cancer, and bladder cancer, among others [20][21][22][23][24][25] . Many hypotheses have been put forward about the role that diabetes might play in tumour development, including mechanisms arising from hyperinsulinemia, hyperglycemia, and insulin resistance 26 .…”

Antihyperglycaemic therapies and cancer risk

“…[4][5][6][7][8][9][10][11][12][13] As already shown in several meta-analyses, patients with type 2 diabetes have an elevated risk of pancreatic, bladder, hepatocellular, ovarian, breast, endometrial, renal, gastric, colorectal and thyroid cancers and, moreover, of non-Hodgkin's lymphoma, leukaemia and myeloma. [14][15][16][17][18][19][20][21][22][23][24] The underlying mechanisms are subject to ongoing investigations, but relevant factors appear to be hyperinsulinaemia due to either insulin resistance or insulin-based therapy, hyperglycaemia, hyperlipidaemia, altered levels of circulating oestrogens and androgens, and inflammatory processes, which have all been associated with an increase in cancer incidence and/ or cancer mortality.…”

Glucocorticoid-Induced Hyperglycemia Is Prevalent and Unpredictable for Patients Undergoing Cancer Therapy: An Observational Cohort Study

“…Those studies also reported a greater risk of cancer mortality in adults with prior impaired glucose tolerance than in those with a normal response. Diabetes is associated with an elevated relative risk of death from colon, pancreatic, and breast cancer 5,[10][11][12] . Hyperglycemia might also be associated with poor cancer treatment outcomes and treatment-related morbidities.…”

“…Diabetes mellitus (dm) and hyperglycemia are associated with an elevated risk of pancreatic [1][2][3][4] , liver [1][2][3][4] , colon 5 , breast 1,6 , and endometrial cancer 1 . Prospective cohort studies that measured insulin response to a glucose load and insulin resistance before the development of cancer have suggested a causative link between impaired glucose metabolism and cancer [7][8][9] .…”