Diabetes mellitus in classical trigeminal neuralgia: A predisposing factor for its development

Xu, Zhenq; Zhang, Ping; Li, Long; He, Huiy; Zhang, Jianch; Sun, Shup

doi:10.1016/j.clineuro.2016.10.015

Cited by 20 publications

(9 citation statements)

References 17 publications

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“…This was followed by MS (n=5, 3.20%), diabetes mellitus (n=3, 1.92%), and thyroid diseases (n=3, 1.92%) ( Table 6 ). In particular, the etiological linkage of hypertension, MS and diabetes mellitus to TN has been discussed in various studies [ 3 , 16 , 23 , 26 , 34 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Percutaneous Radiofrequency Thermocoagulation in Trigeminal Neuralgia : Analysis of Early and Late Outcomes of 156 Cases and 209 Interventions

Gündüz

Cevik

Asiltürk

et al. 2021

J Korean Neurosurg Soc

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Trigeminal neuralgia is one of the most common causes of facial pain. Our aim is to investigate the efficacy and borders of percutaneous radiofrequency thermocoagulation in the treatment of trigeminal neuralgia. Methods : Between May 2007 and April 2017, 156 patients with trigeminal neuralgia were treated with radiofrequency thermocoagulation. These 156 patients underwent 209 procedures. In our study, we investigated the early and late results of percutaneous radiofrequency thermocoagulation under guiding fluoroscopic imaging in the treatment of trigeminal neuralgia. Barrow Neurological Institute (BNI) pain scale was used for grading the early results. In addition, Kaplan-Meier survival analysis was used to assess long-term outcomes. Of the 156 patients who underwent radiofrequency thermocoagulation for trigeminal neuralgia, 45 had additional disease. Patients with this condition were evaluated with their comorbidities. Early and late results were compared with those without comorbidity. Results : In 193 of 209 interventions BNI pain scale I to III results were obtained. Out of the 193 successful operation 136 patients (65.07%) were discharged as BNI I, 14 (6.70%) as BNI II, 43 (20.58%) as BNI III. Sixteen patients (7.65%) remained uncontrolled (BNI IV and V). While the treatment results of trigeminal neuralgia patients with comorbidity seem more successful in the early period, this difference was not observed in follow-up examinations. Conclusion : Finally, we concluded that percutaneous radiofrequency thermocoagulation of the Gasserian ganglion is a safe and effective method in the treatment of trigeminal neuralgia. However, over time, the effectiveness of the treatment decreases. Neverthless, the reapprability of this intervention gives it a distinct advantage.

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Section: Discussionmentioning

confidence: 99%

Percutaneous Radiofrequency Thermocoagulation in Trigeminal Neuralgia : Analysis of Early and Late Outcomes of 156 Cases and 209 Interventions

Gündüz

Cevik

Asiltürk

et al. 2021

J Korean Neurosurg Soc

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“…As a minority of cases of classical trigeminal neuralgia are not caused by vascular compression and appear to be idiopathic, it is possible that disordered physiological, anatomical, genetic, toxic, or degenerative factors may precipitate the generation of abnormal discharges by the Gasserian ganglion, the trigeminal nerve root, or the trigeminal nucleus, causing the neuralgic pain [ 20 , 35 ]. Altered functional activity of sodium channels along trigeminal nociceptive axons, as in the case of diabetic peripheral neuropathy [ 36 ], alterations in the physiological process of the maintenance of the integrity of myelin [ 28 ], and microstructural changes in the trigeminal root in the absence of any vascular pressure [ 28 ] may lead to the generation of abnormal discharges, playing a role in idiopathic classical trigeminal neuralgic pain.…”

Section: Trigeminal Neuralgiamentioning

confidence: 99%

Postherpetic Neuralgia and Trigeminal Neuralgia

Feller

Khammissa

Fourie

et al. 2017

Pain Research and Treatment

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Postherpetic neuralgia (PHN) is an unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons and which can induce psychosocial dysfunction and can negatively impact on quality of life. Preventive options for PHN include vaccination of high-risk persons against HZ, early use of antiviral agents, and robust management of pain during the early stage of acute herpes zoster. If it does occur, PHN may persist for months or even years after resolution of the HZ mucocutaneous eruptions, and treatment is often only partially effective. Classical trigeminal neuralgia is a severe orofacial neuropathic pain condition characterized by unilateral, brief but recurrent, lancinating paroxysmal pain confined to the distribution of one or more of the branches of the trigeminal nerve. It may be idiopathic or causally associated with vascular compression of the trigeminal nerve root. The anticonvulsive agents, carbamazepine or oxcarbazepine, constitute the first-line treatment. Microvascular decompression or ablative procedures should be considered when pharmacotherapy is ineffective or intolerable. The aim of this short review is briefly to discuss the etiopathogenesis, clinical features, and treatment of PHN and classical trigeminal neuralgia.

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“…Diabetes or glucose intolerance can impair vasodilation and lead to ischemia, which is thought to be central to the pathogenesis of peripheral neuropathy, including trigeminal neuralgia. 50 , 51 A recent study demonstrated that patients with glucose intolerance, even without carrying the diagnosis of diabetes, exhibited C-fiber neuropathy, highlighting the devastating effect of prolonged hyperglycemia on neuronal health. 52 On a molecular level, there are at least five prevailing mechanisms of how hyperglycemia leads to different complications of diabetes, with the polyol and PARP pathways being the most relevant to neuronal death.…”

Section: Three Major Types Of Neuropathymentioning

confidence: 99%

An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US

Zeng¹,

Alongkronrusmee²,

Rijn³

2017

JPR

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Neuropathic pain (NeuP) is a syndrome that results from damaged nerves and/or aberrant regeneration. Common etiologies of neuropathy include chronic illnesses and medication use. Chronic disorders, such as diabetes and alcoholism, can cause neuronal injury and consequently NeuP. Certain medications with antineoplastic effects also carry an exquisitely high risk for neuropathy. These culprits are a few of many that are fueling the NeuP epidemic, which currently affects 7%–10% of the population. It has been estimated that approximately 10% and 7% of US adults carry a diagnosis of diabetes and alcohol disorder, respectively. Despite its pervasiveness, many physicians are unfamiliar with adequate treatment of NeuP, partly due to the few reviews that are available that have integrated basic science and clinical practice. In light of the recent Centers for Disease Control and Prevention guidelines that advise against the routine use of μ-opioid receptor-selective opioids for chronic pain management, such a review is timely. Here, we provide a succinct overview of the etiology and treatment options of diabetic and alcohol- and drug-induced neuropathy, three different and prevalent neuropathies fusing the combined clinical and preclinical pharmacological expertise in NeuP of the authors. We discuss the anatomy of pain and pain transmission, with special attention to key ion channels, receptors, and neurotransmitters. An understanding of pain neurophysiology will lead to a better understanding of the rationale for the effectiveness of current treatment options, and may lead to better diagnostic tools to help distinguish types of neuropathy. We close with a discussion of ongoing research efforts to develop additional treatments for NeuP.

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Diabetes mellitus in classical trigeminal neuralgia: A predisposing factor for its development

Cited by 20 publications

References 17 publications

Percutaneous Radiofrequency Thermocoagulation in Trigeminal Neuralgia : Analysis of Early and Late Outcomes of 156 Cases and 209 Interventions

Percutaneous Radiofrequency Thermocoagulation in Trigeminal Neuralgia : Analysis of Early and Late Outcomes of 156 Cases and 209 Interventions

Postherpetic Neuralgia and Trigeminal Neuralgia

An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US

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