Diabetes mellitus in HIV-infected patients receiving antiretroviral therapy

Moyo, Daniel; Tanthuma, G; Mushisha, O.; Kwadiba, G; Chikuse, Fancis F.; Cary, Mark; Steenhoff, Andrew P.; Reid, Michael

doi:10.7196/samj.6792

Cited by 22 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is increased concern on association between infections such as HIV and tuberculosis with diabetes in sub‐Saharan Africa . Although there is a possibility of co‐existence of this infections in pregnant women, of the reviewed studies, only one study reported to have assessed the association between HIV and GDM .…”

Section: Discussionmentioning

confidence: 99%

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Mwanri

Kinabo

Ramaiya

et al. 2015

Tropical Med Int Health

113

109

View full text Add to dashboard Cite

Abstractobjective We systematically reviewed publications on prevalence and risk factors for gestational diabetes mellitus (GDM) in the 47 countries of sub-Saharan Africa.methods We conducted a systematic search in PUBMED and reviewed articles published until June 2014 and searched the references of retrieved articles. We explored sources of heterogeneity among prevalence proportions with metaregression analysis.results Of 1069 articles retrieved 22 studies were included. Half were from West Africa, specifically Nigeria, five from South Africa and six from East and Central Africa. There were differences in screening methods and diagnosis criteria used, even between studies carried out in the same country and same time period. Metaregression analysis indicated high heterogeneity among the studies (I 2 = 100, P < 0.001), which could not be sufficiently explained by study setting, population, diagnostic criteria or time trend, although we observed a relatively higher prevalence in studies carried out after 2000 (5.1% vs. 3.2%), when women at risk were selected (6.5% vs. 3.8%) and when more current diagnostic criteria were used (5.1% vs. 4.2%). Associations with risk factors were reported in six studies. Significant risk factors reported in more than one study were overweight and/ or obesity, family history for type 2 diabetes, previous stillbirth, previous macrosomic child and age >30 years.conclusions There are few studies on prevalence and risk factors for GDM in Sub-Saharan Africa and heterogeneity is high. Prevalence was up to about 14% when high-risk women were studied. Preventive actions should be taken to reduce the short-and long-term complications related to GDM in Sub-Saharan Africa.

show abstract

Section: Discussionmentioning

confidence: 99%

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Mwanri

Kinabo

Ramaiya

et al. 2015

Tropical Med Int Health

113

109

View full text Add to dashboard Cite

show abstract

“…This could be due to the fact that, initiation of ART is associated with rapid weight gain which correlates with increased insulin resistance [27,28]. The higher level of HIV patients from Bamenda compared to patients from Bafoussam is related to the higher prevalence of HIV in this region which has the second higher prevalence of HIV infection after the South region in Cameroon [29].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Predictors and Treatment Outcome of Type 2 Diabetes among Newly Diagnosed Sputum Positive Pulmonary Tuberculosis Patients in Western Cameroon

Fonkeng¹

2017

J Infect Dis Epidemiol

View full text Add to dashboard Cite

“…During early HIV recovery in malnourished patients, rapid regain of fat rather than lean mass may occur [13], and could potentially increase the risk of diabetes. Although HIV and ART may have similar effects on diabetes in SSA as in high-income countries, such data cannot be directly extrapolated to SSA because of differing risk factors such as a lower prevalence of obesity, history of nutritional deficiencies, higher exposure to infections, and use of older antiretroviral drugs which have been associated with excess diabetes risk [14][15][16][17]. We therefore conducted a study to investigate the prevalence of diabetes and to assess the roles of HIV infection, ART and traditional risk factors.…”

Section: Introductionmentioning

confidence: 99%

Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults

et al. 2020

View full text Add to dashboard Cite

BackgroundThe burden of diabetes is increasing in sub-Saharan Africa, including among people living with HIV. We assessed the prevalence of diabetes and the roles of HIV, antiretroviral therapy (ART) and traditional risk factors among adults in Tanzania. MethodsWe analysed diabetes-relevant baseline data from 1,947 adult participants in the CICADA study in Mwanza, Tanzania: 655 HIV-uninfected, 956 HIV-infected ART-naïve, and 336 HIV-infected persons on ART. WHO guidelines for haemoglobin A1c (HbA1c) and oral glucose tolerance test (OGTT) were used to define diabetes and prediabetes. Risk factors were evaluated using multinomial logistic regression analysis. Relative risk ratios (RRR) were generated comparing participants with diabetes and prediabetes against the reference of those with no diabetes. ResultsMean age was 41 (SD 12) years; 59% were women. The prevalence of diabetes was 13% by HbA1c and 6% by OGTT, with partial overlap among participants identified by the two tests. Relative to HIV-uninfected, HIV-infected ART-naïve persons had increased relative risks of diabetes (HbA1c: RRR = 1.95, 95% CI 1.25-3.03; OGTT: RRR = 1.90, 95% CI 0.96-3.73) and prediabetes (HbA1c: RRR = 2.89, 95% CI 1.93-4.34; OGTT: RRR = 1.61, 95% CI 1.22-2.13). HIV-infected participants on ART showed increased risk of prediabetes PLOS ONE

show abstract

Diabetes mellitus in HIV-infected patients receiving antiretroviral therapy

Cited by 22 publications

References 10 publications

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Gestational diabetes mellitus in sub‐Saharan Africa: systematic review and metaregression on prevalence and risk factors

Prevalence, Predictors and Treatment Outcome of Type 2 Diabetes among Newly Diagnosed Sputum Positive Pulmonary Tuberculosis Patients in Western Cameroon

Diabetes prevalence by HbA1c and oral glucose tolerance test among HIV-infected and uninfected Tanzanian adults

Contact Info

Product

Resources

About